Neonatal Neurology

Neonatal Neurology

Handbook of Clinical Neurology Series

1st Edition - July 17, 2019

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  • Editors: Linda de Vries, Hannah Glass
  • Hardcover ISBN: 9780444640291
  • eBook ISBN: 9780444640307

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Neonatal Neurology, Volume 162 in the Handbook of Clinical Neurology, series updates the reader on the latest advances in the study of neurological diseases diagnosed in the fetal and neonatal periods. With recent advances in magnetic resonance imaging, digital electroencephalography recording, and genetic testing and diagnosis, there is expanding awareness relating to early onset neurological conditions and how their early diagnosis can improve prediction of outcome and subsequent neurodevelopmental outcome. This new volume covers diagnosis and management of congenital conditions, including brain malformations, neuromuscular conditions and genetic epilepsies, as well as acquired injury related to peri-partum events, prematurity, critical illness and systemic diseases.

Key Features

  • Provides an in-depth understanding of the basic scientific research, translational research and clinical consensus across neonatal and fetal medicine
  • Explores how early neurological diagnosis can improve prediction of outcome and how management can improve subsequent neurodevelopmental outcome
  • Features chapters co-authored by two experts, combining expertise in both neonatal and fetal neurology


Basic and clinical researchers in neuroscience; fellows, residents, and practicing clinicians in neurology, neonatal neurology, pediatric neurology, and neuropathology

Table of Contents

  • 1. Fetal neurology: principles and practice with a life-course perspective
    2. Fetal toxicology
    3. The placenta
    4. Fetal and neonatal neuro-imaging
    5. Fetal and neonatal neurogenetics
    6. Congenital and perinatal infections
    7. Preterm brain injury (white matter)
    8. Preterm brain injury: germinal matrix / intraventricular hemorrhage and post-hemorrhagic ventricular dilatation
    9. Cerebellar hypoplasia of prematurity: causes and consequences
    10. Neonatal encephalopathy and hypoxic-ischemic encephalopathy
    11. Perinatal arterial ischemic stroke
    12. Neonatal cerebral sinovenous thrombosis
    13. Biomarkers of brain injury
    14. Monitoring and management of brain hemodynamics and oxygenation
    15. Neuroprotection of the preterm brain
    16. Neurodevelopmental outcome of children with congenital heart disease
    17. Seizure classification, etiology and management
    18. Diagnosis of seizures and encephalopathy using conventional EEG and amplitude integrated EEG
    19. Outcome in preterm infants with seizures
    20. Genetics of neonatal onset epilepsies
    21. Neonatal hypotonia and neuromuscular conditions
    22. Inborn errors of metabolism
    23. High risk rollow-up: Early intervention and rehabilitation
    24. Understanding and addressing barriers to communication in the context of neonatal neurologic injury: Exploring the ouR-HOPE approach


Product details

  • No. of pages: 554
  • Language: English
  • Copyright: © Elsevier 2019
  • Published: July 17, 2019
  • Imprint: Elsevier
  • Hardcover ISBN: 9780444640291
  • eBook ISBN: 9780444640307

About the Series Volume Editors

Linda de Vries

Linda de Vries is a neonatologist and pediatric neurologist, and obtained her PhD degree in Utrecht (1987). Since 1989, she has worked in the department of Neonatology in the University Medical Center Utrecht, where she is a professor in Neonatal Neurology. Her research focuses on prediction of neurodevelopmental outcome in high risk preterm and full-term newborns, using neurophysiology and neuro-imaging methods. These at risk children are also seen by her in the follow-up clinic until early childhood. She has a special interest in neonatal stroke and brain plasticity. Her work has been published in >400 publications.

Affiliations and Expertise

Professor of Neonatal Neurology, Department of Neonatology, UMC Utrecht, Utrecht, The Netherlands

Hannah Glass

Dr. Hannah C. Glass is a pediatric neurologist, founding co-director of the Neurointensive Care Nursery (NICN), and Director of Neonatal Critical Care Services at the UCSF Benioff Children's Hospital. She is also the program director of the Neonatal Neurology Fellowship Program. Dr. Glass specializes in brain focused care for children with neurological conditions diagnosed in the newborn period, including hypoxic-ischemic encephalopathy, stroke and seizures, as well as brain injury following preterm birth. Dr. Glass joined the Division of Child Neurology at UCSF in 2006. She earned her medical degree at McGill University and completed pediatrics and child neurology training at the University of Calgary. She trained in neonatal neurology and earned a master's degree in clinical research at UCSF. Dr. Glass has received funding from the National Institutes of Health (NIH), Patient Centered Outcomes Research Institute (PCORI), March of Dimes, Cerebral Palsy Alliance, and the Pediatric Epilepsy Research Foundation to conduct research that aims to improve developmental outcome following newborn brain injury.

Affiliations and Expertise

UCSF School of Medicine, Departments of Neurology, Pediatrics and Epidemiology & Biostatistics, San Francisco, CA, USA

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  • JulianeSchneider Thu Dec 12 2019

    Handbook of Neonatal Neurology

    Very useful update on relevant topics in Neonatal Neurology