Neglected Factors in Pharmacology and Neuroscience Research

1st Edition

Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions

Authors: V. Claassen
Editors: J.P. Huston
Hardcover ISBN: 9780444818713
eBook ISBN: 9781483145891
Imprint: Elsevier
Published Date: 1st January 1994
Page Count: 500
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Techniques in the Behavioral and Neural Sciences, Volume 12: Neglected Factors in Pharmacology and Neuroscience Research: Biopharmaceutics, Animal Characteristics, Maintenance, Testing Conditions can be used as reference in the improvement of test designs for biochemists and physiologists in the control of test conditions.
The book is divided into five sections. The introduction deals with the uncertainty of animal characteristics and test conditions as hindrances to the development of general insight into biological regulatory mechanism. The first section discusses biopharmaceutics — the interaction of drugs when interacting with molecules or enzymes in sufficient concentration at a specific site of action. The second section reviews animal characteristics in terms of strain differences, sex differences, and changes during development and aging of the subject. The third section discusses the maintenance of experimental animals such as housing conditions, food composition, and water intake as these kinds of environmental factors may shape the phenotype and responsiveness of the experimental animal. The fourth section explains the testing conditions such as metabolic effects and drug interactions, anesthesia, stress, and even the effects on circadian rhythms. The last section is a discussion on the importance of experimental results. This section covers internal and external validities and statistical inference. The author concludes that the design of any experiment should include a power analysis so that reliable and valuable conclusions can follow.
Biochemists, physiologists, pharmacokineticists, toxicologists, chemical researchers, and others for whom drugs are their main focus of study will find this book valuable.

Table of Contents

Chapter 1 Introduction: Reproducibility of Animal Experiments Section A Biopharmaceutics Chapter 2 Intravenous Drug Administration Rate of Drug Administration Administration Volume Tonicity of Injection Fluid Drug Distribution After Intravenous Administration Plasma Drug Concentration Complications Chapter 3 Intramuscular Drug Administration Intramuscular Depot and Drug Absorption Absorption from Aqueous Solutions Absorption from Oily Solutions Absorption from Suspensions Tissue Vulnerability Chapter 4 Subcutaneous Drug Administration Subcutaneous Depot and Drug Absorption Absorption from Aqueous Solutions Absorption from Oily Solutions Absorption from Aqueous Suspensions Pellet Absorption Chapter 5 Intraperitoneal Drug Administration Errors of Intraperitoneal Injections Drug Absorption Pathway Absorption from Aqueous Formulations Tolerance Chapter 6 Oral Drug Administration Intraluminal Aspects Volume of Drug Solution Viscosity of Drug Solution Osmotic Pressure of Drug Solution Cosolvents Solubilized Systems Lipoidal Vehicles Solid Dosage Forms Section B Animal Characteristics Chapter 7 Inbred Strains and Outbred Stocks Inbred Strains Random-Bred Stocks Chapter 8 Male - Female Differences Oestrous Cycle Sex-Related Differences Chapter 9 Changes During Development and Aging Growing Older Pharmacokinetic Aspects Pharmacodynamic Aspects Toxicological Aspects Section C Maintenance of Experimental Animals Chapter 10 Housing Conditions Animal Cage and Animal Room


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© Elsevier 1994
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About the Author

V. Claassen

Affiliations and Expertise

Solvay Duphar BV, Weesp, The Netherlands

About the Editor

J.P. Huston