Natural Killer Cells

Natural Killer Cells

Basic Science and Clinical Application

1st Edition - November 12, 2009

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  • Editors: Michael Lotze, Angus Thomson
  • Hardcover ISBN: 9780123704542
  • eBook ISBN: 9780080919294

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Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine.

Key Features

  • Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners
  • Includes figures, histologic sections, and illustrations of the ontogeny of NK cells


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Table of Contents

  • Contributors



    Part I. NK biology

    1 Developmental stages and pathways of NK cell maturation

    2 Developmental origins of thymus-derived natural killer cells

    3 Interferon-producing killer dendritic cells (IKDC)

    4 Natural killer cells in cancer

    5 NK cell immune recognition: NKG2D ligands and stressed cells

    6 NK cell KIR heterogeneity and evolution

    7 Signalling events in natural killer cells

    8 Human natural killer cell development

    Part II. NK interactions with other cells

    9 Isolation, culture and propagation of natural killer cells

    10 The localization and migration of natural killer cells in health and disease

    11 Receptors on NK cells

    12 Development and testing of NK cell lines

    13 NK cell-derived cytokines and delivery: NK cell synapses

    14 NK cells as recipients of cytokine signals

    15 NK cells and chemokines

    16 Natural killer cytolytic activity

    17 Illuminating intranodal natural killer cell behaviour using two-photon microscopy

    18 Dendritic cells and NK cells

    19 NK and NKT cells: the innate – adaptive interface including humoral responses

    20 NK cell and endothelial cell interactions

    21 Natural killer cell/epithelial interactions

    22 NK cell – T cell interactions

    Part III. NK cells in the tissues

    23 NK cells and NKT cells in cutaneous disorders

    24 Natural killer cells in the respiratory tract

    25 Intestinal natural killer cells

    26 Natural killer cells in the liver

    27 Natural killer cells in the spleen and lymph node

    28 Natural killer cells in the central nervous system

    29 NK cells in the eye

    30 NK cells and reproduction

    31 Identification of natural killer cells in tissues and their isolation

    32 Natural killer cell immune regulation: coordination of immune function in tissues

    Part IV. NK cells in disease

    33 Natural killer cells and transplantation

    34 Natural killer cells and autoimmunity

    35 Interaction of NK cells with bacteria

    36 Natural killer cells and human immunodeficiency virus

    37 Cytomegalovirus infection and NK cells

    38 Natural killer cells in allergy

    39 Natural killer cells in wound healing

    40 Natural killer cells in atherosclerosis

    41 Natural killer cells in leukaemia

    42 Natural killer cells and allogeneic haematopoietic cell transplantation

    43 Clinical trials of NK cells for cancer

    44 Natural killer cells and hepatitis C virus infection

    45 Natural killer cells and the biology of parasitism

    46 Lymphoproliferative disorders of natural killer cells

    Part V. Special topics in NK biology

    47 Natural killer cell induction of tolerance

    48 Genetic engineering of natural killer cells

    49 NK cell-mediated target cell death

    50 NK-cell tracking using non-invasive imaging modalities

    Subject Index

    Color Plate Section

Product details

  • No. of pages: 660
  • Language: English
  • Copyright: © Academic Press 2009
  • Published: November 12, 2009
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123704542
  • eBook ISBN: 9780080919294

About the Editors

Michael Lotze

Affiliations and Expertise

Departments of Surgery and Bioengineering, University of Pittsburgh Cancer Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

Angus Thomson

Affiliations and Expertise

Departments of Surgery and Immunology, Thomas E. Starzl Transplantation Institute, University of Pittsburgh Schools of the Health Sciences, Pittsburgh, Pennsylvania, USA

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