Nasopharyngeal Carcinoma - 1st Edition - ISBN: 9780128149362

Nasopharyngeal Carcinoma

1st Edition

From Etiology to Clinical Practice

Editors: Anne Lee Maria Lung Wai Ng
Paperback ISBN: 9780128149362
Imprint: Academic Press
Published Date: 1st May 2019
Page Count: 400
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Description

Nasopharyngeal Carcinoma: From Aetiology to Clinical Practice discusses NPC from basic science, to clinical management through the perspective of members of the Centre for Nasopharyngeal Carcinoma Research in Hong Kong. It encompasses not only the most detailed information about multiple aspects of NPC, but also the modern day research model of scientist-clinician collaboration, focusing on bench-to-bedside approach. Basic science is covered, discussing genetics and genomics in NPC and its epidemiology and the role of Epstein-Barr Virus (EBV). Translational research is also covered, presenting topics such as animal models, plasma EBV DNA, molecular imaging and immunotherapy, amongst other topics.

This book is a valuable source for cancer researchers, oncologists, medical oncologists and several members of the biomedical field who are interested in learning more about NPC management from both clinical and research perspectives.

Key Features

  • Written by members of the Centre for Nasopharyngeal Carcinoma Research
  • Extensively covers various aspects of NPC, including basic science and the clinical advances of both scientists and clinicians
  • Discusses the molecular information gained through laboratory studies to stimulate research on new treatment strategies

Readership

Graduate students on cancer, cancer researchers, clinicians, oncologists

Table of Contents

1. Nasopharyngeal carcinoma: A history
2. NPC genetics and genomics
3. Pathogenesis of nasopharyngeal carcinoma: histogenesis, EBV infection and tumour microenvironment
4. Epidemiology and population screening
5. Establishment of NPC cell line, patient-derived xenografts (PDXs) and immortalized nasopharyngeal epithelial cells for NPC and EBV infection study
6. Translational studies: Drug candidates and preclinical testing
7. Conventional and novel diagnostic biomarkers and approaches for detection of nasopharyngeal carcinoma
8. Imaging of nasopharyngeal carcinoma
9. Staging of nasopharyngeal carcinoma based on 8th edition of the AJCC/UICC staging system
10. Standard of care for NPC (2018-2020)
11. International consensus on delineation of target volumes and organs at risk
12. Advances in radiotherapy
13. Salvage of local recurrence
14. Management of metastatic nasopharyngeal carcinoma
15. Cancer immunotherapy for nasopharyngeal carcinoma
16. Concluding chapter: Nasopharyngeal carcinoma – basic science
17. Concluding chapter: Nasopharyngeal cancer – clinical aspects

 

Details

No. of pages:
400
Language:
English
Copyright:
© Academic Press 2019
Published:
Imprint:
Academic Press
Paperback ISBN:
9780128149362

About the Editor

Anne Lee

Prof. Lee is currently the Clinical Professor and Head of the Department of Clinical Oncology, The University of Hong Kong, and she is also the Chief of Service for the Center of Clinical Oncology at The University of Hong Kong-Shenzhen Hospital as well as the Chair of Specialty for Oncology at Gleneagles Hospital. She serves in many international academic organizations, including being the Coordinator of the Global Advisory Group and a member of TNM Expert Advisory Panel on Head and Neck Cancers for the UICC and Vice-Chairman of the National Cancer Staging Committee of China. She has extensive publications in leading scientific journals focusing on various aspects of NPC research. She is also the recipient of many awards and honours from all over the world for her contributions to cancer research including the Sir Patrick Manson Gold Medal by The University of Hong Kong; Gilbert Fletcher Distinguished Professor Lecturer by The University of Texas, M.D. Anderson Cancer Center; Honorary Membership by the ESTRO; and Honorary Membership by the RSNA.

Affiliations and Expertise

Clinical Professor and Head of the Department of Clinical Oncology, The University of Hong Kong

Maria Lung

Prof. Lung is currently the Chair Professor in the Department of Clinical Oncology, The University of Hong Kong. She is also the Director of the Area of Excellence Center for Nasopharyngeal Carcinoma (NPC) Research and the Laboratory of Cancer Molecular Genomics. She has been studying the contributions of host genetics and Epstein-Barr Virus (EBV) infection to the development of the cancer. She published extensively on EBV genotypes associated with NPC. Her early studies on the molecular genetic basis of NPC utilized functional approaches to complement defects in NPC cell lines, resulting in identification of critical regions and then candidate tumor suppressor genes contributing to the development of these tumors. More recently, using next-generation sequencing (NGS) approaches, she has contributed to our understanding of the basis for genetic susceptibility to NPC in familial and early-age onset cases. Whole-exome sequencing was also utilized to determine the molecular landscape of genetic alterations in NPC. She is currently the Director of an Area of Excellence group grant that established a Center for NPC Research focusing on basic, translational, and clinical research. This AoE grant includes several universities and public hospitals and basic, translational, and clinical research efforts focus on the importance of NPC in Hong Kong. She is also the Founding Co-Chair of the Nasopharyngeal Carcinoma Gordon Research Conference that hosts international meetings on different aspects of NPC every other year. Her international stature in NPC research is well-established as evidenced by her invitations to NPC meetings and as a guest editor for the April 2012 Seminars in Cancer Biology issue on “Unlocking the Rosetta stone enigma for NPC: genetics, viral infection, and other environmental factors.”

Affiliations and Expertise

Chair Professor, Director of the Area of Excellence Center for Nasopharyngeal Carcinoma (NPC) Research and the Laboratory of Cancer Molecular Genomics, The University of Hong Kong

Wai Ng

Prof. Ng is currently the consultant at Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital and honorary associate professor at Clinical Oncology Department, University of Hong Kong. He is also the council member of the Hong Kong Nasopharyngeal Study Group and the past president of the Hong Kong Head and Neck Society. He has extensive publications in leading scientific journals focusing on various aspects of NPC research. He serves on the editorial board of the several cancer related journals and is a member of TNM Expert Advisory Panel on Head and Neck Cancers for the UICC.

Affiliations and Expertise

Consultant Oncologist, Pamela Youde Nethersole Eastern Hospital, Hong Kong

Ratings and Reviews