Nanotechnology and Regenerative Medicine

Nanotechnology and Regenerative Medicine

History, Techniques, Frontiers, and Applications

1st Edition - November 24, 2022

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  • Editors: Maria Santana, Eliana Souto, Ranjita Shegokar
  • eBook ISBN: 9780323904322
  • Paperback ISBN: 9780323904711

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"Cell niches” are present in several human body tissues as a dynamic microenvironment essential to modulate stem cells’ behavior in health, under injury, and in regenerative processes. The interplay between stem cells and their niche is necessary for sustaining tissues. The extracellular matrix (ECM) is the crucial component of the stem cell. It defines the architectural space, physical binding to the cell membrane, and interactions with the neighborhood cells and supports physical stress. Domains with nano or micrometric sizes define the surface and topology of the ECM, mediating cell interactions and macrophage recruitment to injured sites. Over the last two decades, the integration of biomedicine with other engineering and biomaterial sciences promoted the development of nanotechnology and regenerative medicine toward mimicking the specialized stem cell niches to treat diseases with less invasive and efficient therapies. Innovative approaches in nanotechnology, such as targeting the immunological system, transporting drugs across blood–brain/BBB and blood–retinal barriers/BRB, directing active moiety to specific disease location/organs, encapsulation of multiple components, and promoting signalization and pathway-specific surfaces for cell interactions and growth, are indeed promising. On the other side, developments of biomaterial scaffolds to mimic the cell niches for interactions with stem cells in vitro or in vivo have tremendous potential. The three-dimensional printing technology offers a base for a wide array of applications, for example, developing tissue constructs, mimetic organs, organoids, and organ-on-a-chip, thus avoiding the differences between animal model species and humans. Aiming closer to the natural environments, fresh autologous products from the blood, such as platelet-rich plasma (PRP), contain platelets and leukocytes, providing growth factors, cytokines, and proteins for the resident stem cells in the stages of regeneration. PRP also provides pain relief, reducing disabilities in elderly or diseased people. This book brings thought-provoking multidisciplinary topics on the diverse aspects of basic and applied sciences. The prime focus of the compilation is to understand the challenges researchers encounter in combining nanotechnology and regenerative medicine, ultimately integrating both disciplines for the benefit of the patient and offering them a ray of hope to be cured.

Key Features

  • Presents multi-disciplined knowledge on bench-to-bedside application of nanotechnology in regenerative medicines
  • Highlights the fundamentals, frontiers, limitations, and challenges faced by regenerative medicines
  • Exhibits synergy of biotechnology, nanomedicine, biomedicine, chemical-material engineering, pharmaceutical technology, and applied medical sciences in success of regenerative medicines 


Undergraduate and graduate students, scientists, and professors in multidisciplinary fields such as biotechnology, nanomedicine, biomedicine, chemical and material engineering, pharmaceutical technology and applied medical sciences. Readers of interrelated areas such as biology, chemistry, chemical engineering, and mechanical engineering may also be included in a secondary audience. Technicians and R&D corporate personal of biotechnology, pharmaceutical and medical materials industries are also potential readers

Table of Contents

  • 1. Evolution of nanotechnology in medicines
    Inês Formoso, Ranjita Shegokar, Aleksandra Zielinska, Piotr Eder, Amélia M. Silva, Eliana B. Souto
    2. History and evolution of regenerative medicine
    Maria Helena A. Santana and Stephany C. Huber
    3. Nanotechnologies to deliver drugs through the blood-brain and blood-retinal barriers
    Maria C. Costa, Ranjita Shegokar, Amélia M. Silva, Eliana B. Souto
    4. Thermodynamics of nanoparticle-cell interaction
    Luis, Fernando Mercier Franco and Pedro de Alcântara, Pessoa Filho
    5. Nanogels for drug delivery: physicochemical properties, biological behavior and in vivo applications
    Tatiana N. Pashirova, Ana Beatriz Afonso, Natalia V. Terekhova, Marat I. Kamalov, Patrick Masson, Eliana B. Souto
    6. The role of blood brain and blood retinal barriers in drug delivery
    Bonilla-Vidal, L., Esteruelas, G., Souto, E.B., Espina M., García M. L., Sánchez-López E
    7. Nanotechnology and stem cell therapy for combating COVID-19
    M. Patel, R. Patel, S. Bonde, M. Rai
    8. Lipid nanoparticles-based semi-solid formulations for cosmetic applications: focus on cellulite
    Amélia M Silva, Ana T. Cruz, Joana Nobre, Tiago E. Coutinho, Amanda Cano, Aleksandra Zielinska, Anđelka Kovačević, Patricia Severino, Eliana B. Souto
    9. 3D Bioprinting: An innovative technique for biofabrication applied to regenerative medicine and tissue engineering
    M. C. Teixeira, K. K. Singh, B. A. G. De Melo, P. Severino, J. C. Cardoso, E. B. Souto
    10. Stem cells, organoids, and cellular therapy
    Adriana Oliveira Manfiolli, Robson Amaral, Carolina Caliari-Oliveira
    11. Growth factors, cytokines, and platelet-rich plasma
    Ângela Cristina Malheiros Luzo, Krissia Caroline Leme, Wagner J. Fávaro, Nelson Durán, Gabriel Gaspar Bíscaro, Alexandre Leite Rodrigues de Oliveira, Karim Boumediene, Mira Hammad, Catherine Baugé
    12. The biomaterial niche of platelet-rich plasma and hyaluronic acid matrices for tissue regeneration
    Bruna Alice G. de Melo, Andrea A. M. Shimojo, Carla G. França, Ângela Cristina M. Luzo, José Fabio S.D. Lana, Maria Helena A. Santana
    13. Biomaterials application in wound healing management - from fundamental physiology to advanced technology
    Dias-Ferreira, J., Teixeira, M.C., Severino, P., Boonme, P., Jovanovic, J., Shegokar Ranjita, Zielińska, A., Souto, E.B.
    14. Nanoscaffolds and role of 3D printed surgical dressings for wound healing application
    Mayank Handa, Mukesh Soni, Sarwar Beg, Rahul Shukla
    15. Platelet-rich plasma in pain management
    Claudia Herrera Tambelli
    16. Tissue engineering in wound healing
    José L. Soriano, Manuel Ríos, Elena López, María T.Garrido, Beatriz Clares, Patricia Gálvez
    17. Role of neurogenesis in regenerative medicine
    Dilip Waman Shingare, Kailas Kalicharan Moravkar, Jaywant Pawar, Chandrakantsing Vijaysing Pardeshi
    18. Gut microbiome interventions in regenerative medicine
    Heloisa Balan Assalin, Andrey dos Santos, Alexandro Barbosa de Souza, Reinaldo Gaspar Bastos
    19. Applications of nanotechnology in chronic diseases and tissue regeneration
    Inês Formoso, Ranjita Shegokar, Aleksandra Zielinska, Amélia M. Silva, Eliana B. Souto
    20. Electrically conductive nanomaterials for advanced cardiac tissue regeneration
    Patrícia Severino, Fabio Rocha Formiga, Juliana C. Cardoso, Ricardo L. C. de Albuquerque-Júnior, Marco V. Chaud, Eliana B. Souto
    21. Toxicological screening of nanoparticles for biological applications: Drosophila melanogaster a model of new era
    Patrícia Severino, João Dias-Ferreira, Luciana N. Andrade, Daniele M. Lima, Luciana M. de Hollanda, Classius F. da Silva, Marco Vinicius Chaud, Claudia Carbone, Amélia M. Silva, Massimo Lucarini, Alessandra Durazzo, Raffaele Capasso, Antonello Santini and Eliana B. Souto,

Product details

  • No. of pages: 614
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: November 24, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780323904322
  • Paperback ISBN: 9780323904711

About the Editors

Maria Santana

Maria Helena Andrade Santana is a retired Full Professor in the Department of Materials Engineering at the School of Chemical Engineering, University of Campinas, Brazil. Maria Helena is graduated in Chemical Engineering from the University of Maringa, holds PhD. in Mechanical Engineering from the University of Campinas, Brazil, a postdoctoral in Chemical Engineering from the North Caroline State University, USA, and has a nonmedical degree from the American Academy of Regenerative Medicine (American Board of Regenerative Medicine- South America Chapter) (2016). She has extensive experience in multidisciplinary applications, specifically in fermentation processes, nanotechnology, and regenerative medicine of musculoskeletal systems, and is a member of the National Academy of Engineering, Brazil (2014-present). She received twice (2004 and 2015) the “Zeferino Vaz” award for Scientific Productivity in Chemical Engineering and the Inventors award from the Innovation Agency (2010, 2019), both from the University of Campinas, Brazil.

Affiliations and Expertise

Full Professor, Department of Materials Engineering and Bioprocesses and Coordinator, Laboratory for Development of Biotechnological Processes, School of Chemical Engineering, University of Campinas, Brazil

Eliana Souto

Eliana B. Souto is Habil. Professor from the Department of Pharmaceutical Technology of the Faculty of Pharmacy of University of Porto. Prof. Souto graduated in Pharmaceutical Sciences from University of Coimbra (2000), is holder of a master’s in science degree in Pharmaceutical Technology from University of Porto (2002), and PhD in Pharmaceutical Nanotechnology and Biopharmaceutics from the Institut fuer Pharmazie der Freie Universitaet Berlin, Germany (2005). Her research lines include the design, development, and characterization of new drug delivery systems to overcome biological barriers. Prof. Souto serves as Associate Editor, member of the Editorial Board, and Reviewer of several international scientific journals and has published more than 500 works (original and review papers, books and book chapters) in the field of nanosciences and nanomedicine. Prof. Souto also acts as independent expert for several national, European and international funding agencies, and as consultant for pharmaceutical industry.

Affiliations and Expertise

Professor, Department of Pharmaceutical Technology of the Faculty of Pharmacy, University of Porto, Portugal

Ranjita Shegokar

Ranjita Shegokar holds a Ph.D. degree in Pharmaceutical Technology from the SNDT University, India, and has been a postdoctoral researcher in the Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics at the Free University of Berlin, Germany. For the last many years, she has been working with various multinational pharmaceutical companies in technical/R&D leadership roles. Currently, she serves as Chief Scientific Officer (CSO) at Capnopharm GmbH, Germany. She has authored several research articles, book chapters, and presented her research in many national/international conferences. She has filed multiple patent applications in the area of drug delivery and targeting. Besides that, she has edited many trending books in the area of pharmaceutical nanotechnology and drug delivery aspects. For her research, she has received many prestigious national and international awards among them include recently received prestigious German Innovation Award 2022. Her areas of interest include polymeric nanoparticles, nanocrystals, lipid nanoparticles (SLNs/NLCs), nanoemulsions, cancer drug targeting and the role of excipients in delivery systems. (

Affiliations and Expertise

Postdoctoral Researcher, Department of Pharmaceutics, Biopharmaceutics and NutriCosmetics, Free University of Berlin, Germany

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