Nanostructures for Antimicrobial Therapy

Nanostructures for Antimicrobial Therapy

1st Edition - May 29, 2017

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  • Editors: Anton Ficai, Alexandru Grumezescu
  • Hardcover ISBN: 9780323461528
  • eBook ISBN: 9780323461511

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Nanostructures for Antimicrobial Therapy discusses the pros and cons of the use of nanostructured materials in the prevention and eradication of infections, highlighting the efficient microbicidal effect of nanoparticles against antibiotic-resistant pathogens and biofilms. Conventional antibiotics are becoming ineffective towards microorganisms due to their widespread and often inappropriate use. As a result, the development of antibiotic resistance in microorganisms is increasingly being reported. New approaches are needed to confront the rising issues related to infectious diseases. The merging of biomaterials, such as chitosan, carrageenan, gelatin, poly (lactic-co-glycolic acid) with nanotechnology provides a promising platform for antimicrobial therapy as it provides a controlled way to target cells and induce the desired response without the adverse effects common to many traditional treatments. Nanoparticles represent one of the most promising therapeutic treatments to the problem caused by infectious micro-organisms resistant to traditional therapies. This volume discusses this promise in detail, and also discusses what challenges the greater use of nanoparticles might pose to medical professionals. The unique physiochemical properties of nanoparticles, combined with their growth inhibitory capacity against microbes has led to the upsurge in the research on nanoparticles as antimicrobials. The importance of bactericidal nanobiomaterials study will likely increase as development of resistant strains of bacteria against most potent antibiotics continues.

Key Features

  • Shows how nanoantibiotics can be used to more effectively treat disease
  • Discusses the advantages and issues of a variety of different nanoantibiotics, enabling medics to select which best meets their needs
  • Provides a cogent summary of recent developments in this field, allowing readers to quickly familiarize themselves with this topic area


Biomaterials scientists, materials scientists, biomedical engineers, medicinal chemists and postgraduate students specializing in the areas of nanomedicine, bionanomaterials and nanotechnology applications in healthcare

Table of Contents

  • 1. Antimicrobials: Meeting challenges of antibiotic resistance and drug delivery

      Sanjukta Patra

    2. Nano-antimicrobials: Activity, benefits and weaknesses

      Josef Jampilek

    3. Sensitive And Selective Assay Of Antimicrobials On Nanostructured Materials By Electrochemical Techniques

      Sibel A. Özkan

    4. Antimicrobial Polymeric Nanostructures

      Juan Rodriguez-Hernandez

    5. Thin degradable coatings for optimization of osteointegration associated with simultaneous infection prophylaxis

      Anke Bernstein

    6. Nanostructure and Nanomedicine of Anti-microbial Agents for Neuroinfectious of Neurodegenerative Diseases: Current and Future Perspectives

      Arunachalam Muthuraman

    7. Nanocarriers and Their Potential Application as Antimicrobial Drug Delivery

      Asuman BOZKIR

    8. Delivery of Antimicrobials by Chitosan Composed Therapeutic Nanostructures

      Souto Eliana

    9. Antimicrobial thin coatings prepared by laser processing

      Alexandru Mihai Grumezescu

    10. Antimicrobial Photo Dynamic Therapy With Nanoparticle Vs Conventional Photosensitizer In Oral Diseases

      Reza Fekrazad

    11. The Applications of 19F Magnetic Resonance Spectroscopy and Imaging for the Study of Nanostructures used in Antimicrobial Therapy

      Dorota Bartusik

    12. Esential oils and nanoparticles: new strategy to prevent microbial biofilms

      Alexandru Mihai Grumezescu

    13. Nanocarriers Assisted Antimicrobial Therapy Against Intracellular Pathogens

      Neelesh K. Mehra

    14. Implications, Mechanisms and Applications of Nanomaterials with Antimicrobial Properties

      Alexandru Mihai Grumezescu

    15. Outer Membrane Vesicles Of Gram-Negative Bacteria: Nanoware For Combat Against Microbes And Macrobes

      Rakesh Chander YashRoy

    16. Organic nanocarriers for the delivery of anti-infective agents

      Jan Sobczyński

    17. Nanocarriers for plant-derived natural compounds

      Oguz Bayraktar

    18. Fullerene derivatives in photodynamic inactivation of microorganisms

      Edgardo N. Durantini

    19. Silver iodide (AgI) nanoparticles as an anti-biofilm agent. A case study on gram-negative biofilm forming bacteria

      Marikani Kannan

    20. Nanoformulations for the Therapy of Pulmonary Infections

      Vandana Bharat Patravale

    21. Nanocarriers for photosensitizers for use in the antimicrobial photodynamic therapy

      Jan Sobczyński

    22. Zinc oxide nanostructures: new trend in antimicrobial therapy

      Alexandru Mihai Grumezescu

    23. Copper based Nanoparticles as Antimicrobials

      C. Dendrinou-Samara

    24. Antimicrobial Applications of Superparamagnetic Iron Oxide Nanoparticles: Perspectives and Challenges

      Amedea Barozzi Seabra

    25. Silica nanoparticles as a basis for efficacy of antimicrobial drug

      Alexander Lykov

    26. Silver nanoparticles as antimicrobial agents: past, present, and future

      Luciano Paulino Silva

    27. Encapsulation of lethal, functional and therapeutic medicinal nanoparticles and quantum dots for the improved diagnosis and treatment of infection

      Dipak K. Sarker

    28. Advanced Nanocomposites with Noble Metal Antimicrobial Nanoparticles: how to design a balance among antimicrobial activity, bioactivity and safe delivery to the place of infection

      Marija Vukomanović

    29. Clinical development in antimicrobial nanomedicine: towards novel solutions

      Elaine Del-Bel

    30. The citation classics in antimicrobial nanostructures

      Ozcan Konur

Product details

  • No. of pages: 722
  • Language: English
  • Copyright: © Elsevier 2017
  • Published: May 29, 2017
  • Imprint: Elsevier
  • Hardcover ISBN: 9780323461528
  • eBook ISBN: 9780323461511

About the Editors

Anton Ficai

Anton Ficai is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Romania. His research activity is mainly focused on biomaterials for bone healing and treatment. He has been involved in various projects dealing with bone cancer treatment and pain management (especially associated with bone cancer). His patent application related to bone cancer treatment was recently awarded with the Gold Medal by “BRUSSELS INNOVA - The World Exhibition on Inventions, Research and New Technologies”. Anton Ficai is also active in the field of synthesis and characterization of drug delivery systems, synthesis and characterization of nanomaterials, biomaterials or antimicrobial materials, etc. Dr Ficai serves on he Editorial Board of three journals, and has also been the guest editor of Current Pharmaceutical Design.

He has been awarded over 20 prizes for his academic and research activity, and was invited as Visiting Professor of University of Beira Interior. He has given oral presentations at more than 10 international conferences and published over 100 papers and 12 books and book chapters.

Affiliations and Expertise

Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, Romania

Alexandru Grumezescu

Dr. Grumezescu is Assistant Professor at the Department of Science and Engineering of Oxide Materials and Nanomaterials, in the Faculty of Applied Chemistry and Materials Science, with a second affiliation to the Faculty of Medical Engineering, at the Politehnica University of Bucharest in Romania. He is an experienced and oft-published researcher and editor in the field of nano and biomaterials, and he is the Editor-in-Chief of three journals: Biointerface Research in Applied Chemistry, Letters and Applied NanoBioScience, and Biomaterials and Tissue Engineering Bulletin. He also serves as editor or guest editor for several notable journals. Dr. Grumezescu has published 150 peer-reviewed papers, 20 book chapters, 6 co-authored books and 11 edited books.

Affiliations and Expertise

Assistant Professor, Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science and Faculty of Medical Engineering, Politehnica University of Bucharest, Romania

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