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Nanomedicine and Neuroprotection in Brain Diseases - 1st Edition - ISBN: 9780323901628

Nanomedicine and Neuroprotection in Brain Diseases, Volume 265

1st Edition

Editors: Hari Sharma Aruna Sharma
Hardcover ISBN: 9780323901628
Imprint: Elsevier
Published Date: 1st September 2021
Page Count: 358
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Table of Contents

1. Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta protein
Hari Shanker Sharma, Uppsala, Sweden
2. Nanodelivery of Oxiracetam induces neuroprotection with enhanced memory and functional recovery following concussive head injury
Feng Niu, Shijiazhuang, China
3. Neuroprotective effects of Insulin like growth factor-1 on blood-brain barrier disruption, edema formation, oxidative stress, neuronal nitric oxide synthase upregulation and brain pathology induced by Engineered Ag, Cu and Al metal Nanoparticles
Hari Shanker Sharma, Uppsala, Sweden
4. Clinical neurorestorative cell therapies for stroke
Hongyun Huang, Beijing, China
5. Histamine H3 and H4 receptors modulate Parkinson’s disease induced brain pathology. Neuroprotective effects of nanowired BF-2649 and clobenpropit with anti-histamine-antibody therapy
Aruna Sharma, Uppsala, Sweden
6. Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke
Seaab Sahib, Fayetteville, AR, USA
7. Methamphetamine exacerbates pathophysiology of traumatic brain injury at high altitude. Neuroprotective effects of nanodelivery of a potent antioxidant compound H-290/51
Hari Shanker Sharma, Uppsala, Sweden
8. Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue
Lars Wiklund, Uppsala, Sweden
9. Topical application of CNTF, GDNF and BDNF in combination attenuates blood-spinal cord barrier permeability, edema formation, hemeoxygenase-2 upregulation, and cord pathology
Aruna Sharma, Uppsala, Sweden
10. Diagnosis Experience and Literature Review of Patients with Cervical, Thoracic and Lumbar Multi-segment Spinal Stenosis: A case report
He Chao, Zhejiang, China
11. Superior antioxidant and anti-ischemic neuroprotective effects of Cerebrolysin in heat stroke following intoxication of Engineered metal nanoparticles Ag and Cu: A comparative biochemical and physiological study with other stroke therapies
Hari Shanker Sharma, Uppsala, Sweden
12. Cerebrolysin restores balance between excitatory and inhibitory Amino Acids metabolism in brain following Concussive Head Injury. Superior Neuroprotective effects of TiO2 nanowired drug delivery
Hari Shanker Sharma, Uppsala, Sweden
13. Manganese nanoparticles exposure induce blood-brain barrier disruption, cerebral blood flow, edema formation, brain pathology associated with cognitive and motor dysfunctions
Aruna Sharma, Uppsala, Sweden
14. Early Molecular Biologic Diagnosis Of Malignant And Neurodegenerative Diseases By The Immunospecific Profiles Of The Proteins Markers Of The Surface Of The Mobilized Autologous Hematopoietic Stem Cells
Andrey S. Bryukhovetskiy, Moscow, Russia
15. A Clinical Study of High-dose Urokinase Treatment for Hypertension Induced Ventricular Hemorrhage
He Chao, Zhejiang, China
16. Neuromodulation as a Basic Platform for Neuroprotection and Repair After Spinal Cord Injury
Artur Biktimirov, Vladivostok, Russia
17. Bortezomib and temozolomide are effective in killing cells relapsed glioblastoma resistant to radiation
Oleg Pak, Vladivostok, Russia
18. Glioblastoma: what can we do our best for these patients today and what we will be able to do in the future?
Igor Bryukhovetskiy, Vladivostok, Russia
19. Multimodal imaging in differential diagnosis of glioma recurrence from treatment related effects: a systematic review and network meta-analysis
Cong Li, Guangzhou, China
20. Network Pharmacological Mechanism of Cinobufotalin against Glioma
Cong Li, Guangzhou, China
21. Targeted Therapy with Anlotinib for a Leptomeningeal Spread Recurrent Glioblastoma Patient: a case report
Cong Li, Guangzhou, China


Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Progress in Brain Research series
  • Updated release includes the latest information on the Neuropharmacology of Neuroprotection


Undergraduates, graduates, academics, and researchers in the field of neurology and brain research


No. of pages:
© Elsevier 2021
1st September 2021
Hardcover ISBN:

Ratings and Reviews

About the Editors

Hari Sharma

Dr. Hari Shanker Sharma, Professor of Neurobiology (MRC), Docent in Neuroanatomy (UU) is currently working in Uppsala University Hospital, Department of Surgical Sciences, Division of Anesthesiology & Intensive Care Medicine, Uppsala University, Sweden. Dr Sharma obtained his Masters Degree from Bihar University with special expertise in Cell Biology in 1976 and was awarded the Gold Medal of Bihar University for securing 1st position in the 1st Class. Dr Sharma joined the group of Professor Prasanta Kumar Dey, a neurophysiologist, by training in the Department of Physiology, Institute of Medical; Sciences, Banaras Hindu University, Varanasi in 1977 to obtain his Doctor of Philosophy Degree (D.Phil.) in Neurosciences and was awarded his Ph.D. in 1982 on “Blood-Brain Barrier in Stress.” After carrying out a series of Government of India funded Research Projects on the BBB and brain dysfunction (1982–1987), Dr Sharma joined the lab of Neuropathology at Uppsala University with Professor Yngve Olsson in 1988 to investigate passage of tracer transport across the BBB caused by stress or traumatic insults to the Brain and Spinal cord at light and electron microscopy. Dr Sharma was awarded the prestigious Alexander von Humboldt Foundation Fellowship of German Government (1989–1991) to work on hyperthermia induced BBB dysfunction at the ultrastructural level in the laboratory of Professor Jorge Cervós-Navarro (a living “Legend in Neuropathology in Europe”). Dr Sharma again joined Uppsala University and established a network of collaboration on “Experimental CNS Injury Research Group” as a lead investigator with eminent collaborators in various parts of Europe, USA, and Australia (1991–). On his work on hyperthermia Dr Sharma received the prestigious Neuroanatomy award “Rönnows Research prize” of Uppsala University for “best neuroanatomical research of the year 1996” followed by the Award of the Degree of Doctor of Medical Sciences of Uppsala University in Neuroanatomy in 1999 and selected for the Best Thesis Award of the Medical faculty, “The Hwassers Prize” of 1999. On his meticulous works on the Blood Brain barrier and Brain edema (2000–2003) Dr. Sharma earned the prestigious title of “Docent in Neuroanatomy” of Medical Faculty, Uppsala University in April 2004. Currently his main research interest is Neuroprotection and Neuroregeneration, in relation to the Blood-brain barrier in stress, trauma, and drugs of abuse in health and disease. Dr. Sharma on his research on brain pathology and neuroprotection in different models received the prestigious award from The Laerdal Foundation of Acute Medicine, Stavanger, Norway, in 2005 followed by Distinguished International Scientists Collaboration Award by National Institute on Drug Abuse (NIDA), Baltimore, MD (2006–2008). His recent work on 5-HT3 receptor mediated neuroprotection in morphine withdrawal induced neurotoxicity won the coveted prize of Best Investigator Award 2008 and Best Scientific Presentation by European Federation of the International Association for Study of Pain (ISAP), and Awarded during their VI Annual Meeting in Lisbon, September 9–12, 2008. His recent research is aimed to find out the role of nanoparticles in Neurodegeneration and Neuroprotection using various treatment strategies that is supported by European Aerospace Research and Development (EOARD), London, UK and US Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, Oh, USA. On his works on Blood–brain barrier in hypertension and diabetes together with Romanian colleagues, University of Medicine and Pharmacy “Iuliu Hatieganu,” Cluj-Napoca, Romania awarded Dr. Sharma with Honorary Doctorate of Medical Sciences in 2009. Dr Sharma’s work over 30 years on the blood-brain barrier and brain edema won him the US Neurosurgeon Dr Anthony Marmarou Award (2011) by the International Brain Edema Society at their 15th Congress in Tokyo, Japan, November 2011. His works on Nanoneuroscience and development of nanomedicine to treat the CNS injuries has won accolades at various Government and International Scotties or Organization across the World. Accordingly Dr Sharma was decorated with the most prestigious ”Hind Rattan Award 2012” on the eve of Republic Day of India in January 2012 and Mahatma Gandhi Pravasi Gold Medal in October 2012 in House of Lords, London, UK. Dr Sharma was also invited to organize and chair Nanosymposium in Society for Neuroscience meetings in Chicago (2009), San Diego (2010), Washington DC (2011) and New Orleans (2012). Dr Sharma has published over 380 research papers, 75 reviews, 12 monographs, and 70 international book chapters and edited 15 book volumes.

Affiliations and Expertise

Professor, Uppsala University, Sweden

Aruna Sharma

Aruna Sharma, MD is currently Secretary of Research at Uppsala University Hospital, Uppsala University, Sweden. She obtained her Bachelor of Science in 1971 and trained in Indian Medicine up to 1977 and engaged in medical research from 1978 to 1986 in India on hyperthermia induced brain dysfunction in the lab of Hari Sharma and Prasanta Kumar Dey under University Grants Commission and Indian Council of Medical Research Her main interest is now focused on Indian Medicinal drugs and their effects on the Central Nervous System Function, toxicology, neurorepair and neuroprotection. She is also investigating neurotoxicological profiles of many Ayurvedic traditional drugs with special reference to those containing metal oxide or metal ashes.

Affiliations and Expertise

University Hospital, Sweden