Nanomedicine and Neuroprotection in Brain Diseases

Nanomedicine and Neuroprotection in Brain Diseases

1st Edition - September 20, 2021

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  • Editors: Hari Sharma, Aruna Sharma
  • Hardcover ISBN: 9780323901628
  • eBook ISBN: 9780323901635

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Progress in Brain Research series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Progress in Brain Research series
  • Updated release includes the latest information on the Neuropharmacology of Neuroprotection


Undergraduates, graduates, academics, and researchers in the field of neurology and brain research

Table of Contents

  • Chapter 01

    Alzheimer's disease neuropathology is exacerbated following traumatic brain injury. Neuroprotection by co-administration of nanowired mesenchymal stem cells and cerebrolysin with monoclonal antibodies to amyloid beta protein

    Hari Shanker Sharma*1,6, Dafin F Muresanu2,3, Rudy J Castellani4, Ala Nozari5, JosŽ Vicente Lafuente6, Anca D. Buzoianu7, Seaab Sahib8, Z Ryan Tian8, Igor Bryukhovetskiy 9,10, Igor Manzhulo 9,10, Preeti K Menon11, Ranjana Patnaik1,12, Lars Wiklund1, Aruna Sharma*1

    Chapter 02

    Glioblastoma: what can we do for these patients today and what will we be able to do in the future?

    Igor Bryukhovetskiy1, Aleksandra Kosianova1, Sergey Zaitsev1, Oleg Pak1, Aruna Sharma2, Hari Shanker Sharma2

    Chapter 03

    Network Pharmacological Mechanism of Cinobufotalin against Glioma

    Cong Lia,#, Hanyu Guoa,#, Chao Wanga,#, Wengang Zhana, Qijia Tana, Caijun Xiea, Aruna Sharmab, Hari

    Shanker Sharmab,*, Lin Chenc,*, Zhiqiang Zhanga,


    Chapter 04

    Nanodelivery of Oxiracetam enhances memory, functional recovery and induces neuroprotection following concussive head injury

    Feng Niu1, Aruna Sharma*2, Zhenguo Wang1, Lianyuan Feng3, Dafin F Muresanu4,5, Seaab Sahib6, Z Ryan Tian6, JosŽ Vicente Lafuente7, Anca D. Buzoianu8, Rudy J Castellani9, Ala Nozari10, Preeti K Menon1,11,12, Ranjana Patnaik11, Lars Wiklund2, Hari Shanker Sharma*2,7

    Chapter 05

    Clinical neurorestorative cell therapies for stroke

    Hongyun Huang1,2, Gengsheng Mao1, Lin Chen3, Hari Shanker Sharma4


    Chapter 06

    Nanodelivery of traditional Chinese Gingko Biloba extract EGb-761 and bilobalide BN-52021 induces superior neuroprotective effects on pathophysiology of heat stroke

    Seaab Sahib1, Aruna Sharma*2, Dafin F Muresanu3,4, Zhiqiang Zhang5, Cong Li5, Z Ryan Tian1, Anca D. Buzoianu6, JosŽ Vicente Lafuente7, Rudy J Castellani8, Ala Nozari9, Ranjana Patnaik10, Preeti K Menon1,10,11, Lars Wiklund2, Hari Shanker Sharma*2,7


    Chapter 07

    Upregulation of hemeoxygenase enzymes HO-1 and HO-2 following ischemia-reperfusion injury in connection with experimental cardiac arrest and cardiopulmonary resuscitation: Neuroprotective effects of methylene blue

    Lars Wiklund1, Aruna Sharma*1, Ranjana Patnaik2, Dafin F Muresanu3,4, Seaab Sahib5,Z Ryan Tian5, Rudy J Castellani6, Ala Nozari7, JosŽ Vicente Lafuente8, Hari Shanker Sharma*1,8,


    Chapter 08

    Multimodal imaging in the differential diagnosis of glioma recurrence from treatment-related effects: a systematic review and network meta-analysis. A protocol for systematic review and network metaanalysis

    Huijing Chena, #, Yanwen Luob,#, Cong Lic,#, Wengang Zhanc, Qijia Tanc, Caijun Xiec, Aruna Sharmad,*, Hari Shanker Sharmad,*, Zhiqiang Zhangc,*

    Chapter 09

    Manganese nanoparticles induce blood-brain barrier disruption, cerebral blood flow reduction, edema formation and brain pathology associated with cognitive and motor dysfunctions

    Aruna Sharma*1, Lianyuan Feng2, Dafin F Muresanu3,4, Seaab Sahib5, Z Ryan Tian5, JosŽ Vicente Lafuente6, Anca D. Buzoianu7, Rudy J Castellani8, Ala Nozari9, Lars Wiklund1, Hari Shanker Sharma*1,6

    Chapter 10

    Targeted Therapy with Anlotinib for a Leptomeningeal Spread Recurrent Glioblastoma Patient

    Cong Lia,#, Wenyu Lib,#, Shuang Daic, Aruna Sharmad, Hari Shanker Sharmad,*, Youliang Wua,*

Product details

  • No. of pages: 442
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: September 20, 2021
  • Imprint: Elsevier
  • Hardcover ISBN: 9780323901628
  • eBook ISBN: 9780323901635

About the Editors

Hari Sharma

Dr. Hari Shanker Sharma, Professor of Neurobiology (MRC), Docent in Neuroanatomy (UU) is currently working in Uppsala University Hospital, Department of Surgical Sciences, Division of Anesthesiology & Intensive Care Medicine, Uppsala University, Sweden. Dr Sharma obtained his Masters Degree from Bihar University with special expertise in Cell Biology in 1976 and was awarded the Gold Medal of Bihar University for securing 1st position in the 1st Class. Dr Sharma joined the group of Professor Prasanta Kumar Dey, a neurophysiologist, by training in the Department of Physiology, Institute of Medical; Sciences, Banaras Hindu University, Varanasi in 1977 to obtain his Doctor of Philosophy Degree (D.Phil.) in Neurosciences and was awarded his Ph.D. in 1982 on “Blood-Brain Barrier in Stress.” After carrying out a series of Government of India funded Research Projects on the BBB and brain dysfunction (1982–1987), Dr Sharma joined the lab of Neuropathology at Uppsala University with Professor Yngve Olsson in 1988 to investigate passage of tracer transport across the BBB caused by stress or traumatic insults to the Brain and Spinal cord at light and electron microscopy. Dr Sharma was awarded the prestigious Alexander von Humboldt Foundation Fellowship of German Government (1989–1991) to work on hyperthermia induced BBB dysfunction at the ultrastructural level in the laboratory of Professor Jorge Cervós-Navarro (a living “Legend in Neuropathology in Europe”). Dr Sharma again joined Uppsala University and established a network of collaboration on “Experimental CNS Injury Research Group” as a lead investigator with eminent collaborators in various parts of Europe, USA, and Australia (1991–). On his work on hyperthermia Dr Sharma received the prestigious Neuroanatomy award “Rönnows Research prize” of Uppsala University for “best neuroanatomical research of the year 1996” followed by the Award of the Degree of Doctor of Medical Sciences of Uppsala University in Neuroanatomy in 1999 and selected for the Best Thesis Award of the Medical faculty, “The Hwassers Prize” of 1999. On his meticulous works on the Blood Brain barrier and Brain edema (2000–2003) Dr. Sharma earned the prestigious title of “Docent in Neuroanatomy” of Medical Faculty, Uppsala University in April 2004. Currently his main research interest is Neuroprotection and Neuroregeneration, in relation to the Blood-brain barrier in stress, trauma, and drugs of abuse in health and disease. Dr. Sharma on his research on brain pathology and neuroprotection in different models received the prestigious award from The Laerdal Foundation of Acute Medicine, Stavanger, Norway, in 2005 followed by Distinguished International Scientists Collaboration Award by National Institute on Drug Abuse (NIDA), Baltimore, MD (2006–2008). His recent work on 5-HT3 receptor mediated neuroprotection in morphine withdrawal induced neurotoxicity won the coveted prize of Best Investigator Award 2008 and Best Scientific Presentation by European Federation of the International Association for Study of Pain (ISAP), and Awarded during their VI Annual Meeting in Lisbon, September 9–12, 2008. His recent research is aimed to find out the role of nanoparticles in Neurodegeneration and Neuroprotection using various treatment strategies that is supported by European Aerospace Research and Development (EOARD), London, UK and US Air Force Research Laboratory, Wright Patterson Air Force Base, Dayton, Oh, USA. On his works on Blood–brain barrier in hypertension and diabetes together with Romanian colleagues, University of Medicine and Pharmacy “Iuliu Hatieganu,” Cluj-Napoca, Romania awarded Dr. Sharma with Honorary Doctorate of Medical Sciences in 2009. Dr Sharma’s work over 30 years on the blood-brain barrier and brain edema won him the US Neurosurgeon Dr Anthony Marmarou Award (2011) by the International Brain Edema Society at their 15th Congress in Tokyo, Japan, November 2011. His works on Nanoneuroscience and development of nanomedicine to treat the CNS injuries has won accolades at various Government and International Scotties or Organization across the World. Accordingly Dr Sharma was decorated with the most prestigious ”Hind Rattan Award 2012” on the eve of Republic Day of India in January 2012 and Mahatma Gandhi Pravasi Gold Medal in October 2012 in House of Lords, London, UK. Dr Sharma was also invited to organize and chair Nanosymposium in Society for Neuroscience meetings in Chicago (2009), San Diego (2010), Washington DC (2011) and New Orleans (2012). Dr Sharma has published over 380 research papers, 75 reviews, 12 monographs, and 70 international book chapters and edited 15 book volumes.

Affiliations and Expertise

Professor, Uppsala University, Sweden

Aruna Sharma

Aruna Sharma, MD is currently Secretary of Research at Uppsala University Hospital, Uppsala University, Sweden. She obtained her Bachelor of Science in 1971 and trained in Indian Medicine up to 1977 and engaged in medical research from 1978 to 1986 in India on hyperthermia induced brain dysfunction in the lab of Hari Sharma and Prasanta Kumar Dey under University Grants Commission and Indian Council of Medical Research Her main interest is now focused on Indian Medicinal drugs and their effects on the Central Nervous System Function, toxicology, neurorepair and neuroprotection. She is also investigating neurotoxicological profiles of many Ayurvedic traditional drugs with special reference to those containing metal oxide or metal ashes.

Affiliations and Expertise

Secretary of Research, Uppsala University Hospital, Uppsala University, Sweden

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