Nanomaterials in Tissue Engineering

Nanomaterials in Tissue Engineering

Fabrication and Applications

1st Edition - July 31, 2013

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  • Editors: A K Gaharwar, S Sant, M J Hancock, S A Hacking
  • Hardcover ISBN: 9780857095961
  • eBook ISBN: 9780857097231

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Description

Nanomaterial technologies can be used to fabricate high-performance biomaterials with tailored physical, chemical, and biological properties. They are therefore an area of interest for emerging biomedical technologies such as scaffolding, tissue regeneration, and controlled drug delivery. Nanomaterials in tissue engineering explores the fabrication of a variety of nanomaterials and the use of these materials across a range of tissue engineering applications.Part one focuses on the fabrication of nanomaterials for tissue engineering applications and includes chapters on engineering nanoporous biomaterials, layer-by-layer self-assembly techniques for nanostructured devices, and the synthesis of carbon based nanomaterials. Part two goes on to highlight the application of nanomaterials in soft tissue engineering and includes chapters on cardiac, neural, and cartilage tissue engineering. Finally, the use of nanomaterials in hard tissue engineering applications, including bone, dental and craniofacial tissue engineering is discussed in part three.Nanomaterials in tissue engineering is a standard reference for researchers and tissue engineers with an interest in nanomaterials, laboratories investigating biomaterials, and academics interested in materials science, chemical engineering, biomedical engineering and biological sciences.

Key Features

  • Explores the fabrication of a variety of nanomaterials and their use across a range of tissue engineering applications
  • Examines engineering nanoporous biomaterials, layer-by-layer self-assembly techniques for nanostructured devices, and the synthesis of carbon based nanomaterials
  • Highlights the application of nanomaterials in soft tissue engineering and includes chapters on cardiac, neural, and cartilage tissue engineering

Readership

Biomedical engineering researchers and researchers interested in biomaterials, tissue engineering and regenerative medicine; Materials scientists; Chemical engineers;

Table of Contents

  • Contributor contact details

    Woodhead Publishing Series in Biomaterials

    Foreword

    Introduction

    Chapter 1: Biomedical nanomaterials in tissue engineering

    Abstract:

    1.1 Introduction

    1.2 Overview of nanomaterials in tissue engineering

    1.3 Biomedical nanomaterials in tissue engineering applications

    1.4 Future trends

    Part I: Fabrication of nanomaterials for tissue engineering applications

    Chapter 2: Synthesis of polymeric nanomaterials for biomedical applications

    Abstract:

    2.1 Introduction

    2.2 Types of polymers used in nanomaterials

    2.3 Synthesis of polymeric nanoparticles

    2.4 Synthesis of polymeric scaffolds

    2.5 Characterization of the nanomaterials

    2.6 Future trends

    Chapter 3: Engineering nanoporous biomaterials

    Abstract

    3.1 Introduction

    3.2 Nanotubes and etched nanoporous surfaces

    3.3 Self-assembled supramolecular organic templates

    3.4 Self-assembled colloidal templates

    3.5 Conclusion

    Chapter 4: Layer-by-layer self-assembly techniques for nanostructured devices in tissue engineering

    Abstract:

    4.1 Introduction

    4.2 Interaction between biomaterials as ingredients for multilayer formulations

    4.3 Scalability to three dimensions

    4.4 Application of nanostructured multilayer devices in tissue engineering

    Conclusion

    Chapter 5: Synthesis of carbon based nanomaterials for tissue engineering applications

    Abstract:

    5.1 Introduction

    5.2 Carbon nanotubes and fibers

    5.3 Fullerenes (C60)

    5.4 Graphene

    5.5 Nanodiamond systems

    5.6 Carbon-nanostructured materials

    5.7 Conclusion

    Chapter 6: Fabrication of nanofibrous scaffolds for tissue engineering applications

    Abstract:

    6.1 Introduction

    6.2 Methods for nanofibrous scaffolds fabrication

    6.3 Surface modification of nanofibrous scaffolds

    6.4 Applications of nanofibrous scaffolds in tissue engineering

    6.5 Conclusion

    Chapter 7: Fabrication of nanomaterials for growth factor delivery in tissue engineering

    Abstract:

    7.1 Introduction

    7.2 Strategies for controlled growth factor delivery in tissue engineering

    7.3 Nanostructures for growth factor delivery in tissue engineering

    7.4 Nanofibers

    7.5 Nanoparticles

    7.6 Strategies for dual growth factor, drug and gene delivery

    7.7 Clinical prospective of nanostructures with growth factor delivery in tissue engineering

    7.8 Conclusion and future trends

    Part II: Application of nanomaterials in soft tissue engineering

    Chapter 8: Nanomaterials for engineering vascularized tissues

    Abstract:

    8.1 Introduction

    8.2 Biocomplexity of vascularized tissues

    8.3 Engineering nanomaterials to improve vascularization of tissues

    8.4 Clinical progress

    8.5 Conclusion and future trends

    Chapter 9: Nanomaterials for cardiac tissue engineering

    Abstract:

    9.1 Introduction

    9.2 Heart muscle structure and diseases

    9.3 Cardiac tissue engineering (CTE)

    9.4 Application of nanomaterials and nanofabrication methods in CTE

    9.5 Case study: magneto-mechanical cell stimulation to promote CTE

    9.6 Conclusion and future trends

    9.7 Acknowledgements

    Chapter 10: Nanomaterials for neural tissue engineering

    Abstract:

    10.1 Introduction to neural tissue engineering

    10.2 Nano-scaffold design techniques

    10.3 Nano-structures

    10.4 Biomaterials for scaffold design

    10.5 Drawbacks of the use of nanomaterials

    10.6 Conclusion and future trends

    10.7 Acknowledgements

    Chapter 11: Nanomaterials for cartilage tissue engineering

    Abstract:

    11.1 Introduction

    11.2 Cartilage biology and structure

    11.3 Clinical approaches in the treatment of cartilage defects

    11.4 Nanomaterials: strategies for cartilage regeneration

    11.5 Conclusion

    Chapter 12: Biomaterials and nano-scale features for ligament regeneration

    Abstract:

    12.1 Introduction

    12.2 Anterior cruciate ligament (ACL) composition, structure and properties

    12.3 Injury, healing and treatment of the ACL

    12.4 Engineered scaffold materials for ligament regeneration

    12.5 Methods for enhancing engineered scaffolds for ligament regeneration

    12.6 Conclusion and future trends

    Part III: Application of nanomaterials in hard tissue engineering

    Chapter 13: Nanomaterials for hard–soft tissue interfaces

    Abstract:

    13.1 Introduction

    13.2 Nanoparticles

    13.3 Nanofibers

    13. 4 Strategies incorporating nanomaterials in hard–soft tissue interfaces

    13 5 Conclusion and future trends

    Chapter 14: Mineralization of nanomaterials for bone tissue engineering

    Abstract:

    14.1 Bone: a nanobiocomposite material

    14.2 Collagen as a biomaterial

    14.3 Approaches to the mineralization of collagenous constructs

    14.4 Conclusion

    Chapter 15: Nanomaterials for dental and craniofacial tissue engineering

    Abstract:

    15.1 Introduction

    15.2 Nanotechnology for engineered substrates

    15.3 Engineering mineralized collagenous craniofacial structures

    15.4 Nano-scale scaffolds with integrated delivery systems

    15.5 Micro/nano-arrays as libraries for high-throughput characterization

    15.6 Conclusion

    Index

Product details

  • No. of pages: 468
  • Language: English
  • Copyright: © Woodhead Publishing 2013
  • Published: July 31, 2013
  • Imprint: Woodhead Publishing
  • Hardcover ISBN: 9780857095961
  • eBook ISBN: 9780857097231

About the Editors

A K Gaharwar

Dr Akhilesh K. Gaharwar works in the David H. Koch Institute for Integrative Cancer Research at Massachusetts Institute of Technology, USA, and is also a research fellow in the Wyss Institute for Biologically Inspired Materials at Harvard University, USA.

Affiliations and Expertise

Harvard Medical School and Massachusetts Institute of Technology

S Sant

Dr Shilpa Sant is an Assistant Professor in the Department of Pharmaceutical Sciences, School of Pharmacy and Department of Bioengineering at the University of Pittsburgh, USA. She is also an affiliate faculty member at McGowan Institute for Regenerative Medicine, Pittsburgh, USA.

Affiliations and Expertise

University of Pittsburgh and Harvard Medical School

M J Hancock

Dr Matthew J. Hancock is a research scientist at Broad Institute, USA.

Affiliations and Expertise

Broad Institute

S A Hacking

Dr Adam A. Hacking is the director of the Laboratory for Musculoskeletal Research and Innovation (LMRI) in the Department of Orthopaedics at the Massachusetts General Hospital and Harvard Medical School, USA.

Affiliations and Expertise

Massachusetts General Hospital, USA

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