Nanomaterials for Magnetic and Optical Hyperthermia Applications

Nanomaterials for Magnetic and Optical Hyperthermia Applications

1st Edition - November 30, 2018

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  • Editors: Raluca Fratila, Jesús Martínez De La Fuente
  • Paperback ISBN: 9780128139288
  • eBook ISBN: 9780128139295

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Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-gold nanoparticles) for in vitro and in vivo hyperthermia applications, both as standalone and adjuvant therapy in combination with chemotherapy. The book explores the potential for more effective cancer therapy solutions through the synergistic use of nanostructured materials as magnetic and optical hyperthermia agents and targeted drug delivery vehicles, while also discussing the challenges related to their toxicity, regulatory and translational aspects. In particular, the book focuses on the design, synthesis, biofunctionalization and characterization of nanomaterials employed for magnetic and optical hyperthermia. This book will be an important reference resource for scientists working in the areas of biomaterials and biomedicine seeking to learn about the potential of nanomaterials to provide hyperthermia solutions.

Key Features

  • Explores the design of efficient nanomaterials for hyperthermia applications, allowing readers to make informed materials selection decisions
  • Discusses the biofunctionalization of a range of nanomaterials and their interaction with living systems
  • Provides an overview of the current clinical applications of nanomaterials in hyperthermia treatment


Materials Scientists and Biomedical Scientists

Table of Contents

  • Contents


    Introduction to Hyperthermia

    Raluca M. Fratila, Jesús M. de la Fuente

    1 Hyperthermia as Therapeutic Approach

    2 Hyperthermia at the Nanoscale—Why


    3 About This book

    4 References



    1. Design Criteria of Thermal Seeds for Magnetic Fluid Hyperthermia From Magnetic Physics Point of View

    Hiroaki Mamiya, Balachandran Jeyadevan

    1.1 Introduction

    1.2 Mechanism of Heat Generation

    1.3 Operational Limits of Magnetic Field and Frequency Conditions

    1.4 Novel Responses of Individual Magnetic

    Nanoparticles to AC Magnetic Fields

    1.5 Potential of Interacting MagneticNanoparticles

    1.6 Summary and Perspectives


    2. Design of Anisotropic Iron-Oxide-Based

    Nanoparticles for Magnetic Hyperthermia

    Geoffrey Cotin, Francis Perton, Cristina Blanco-Andujar, Benoit Pichon, Damien Mertz, Sylvie Bégin-Colin

    2.1 Key Parameters Controlling the Generated Heat

    2.2 Optimization of MH Properties of IONPs by Doping or Shape-Controlled Synthesis

    2.3 Conclusion


    3. Synthesis and Characterization of Magnetic–Plasmonic Hybrid Nanoparticles

    Mari Takahashi, Ryoichi Kitaura, Priyank Mohan, Shinya Maenosono

    3.1 Introduction

    3.2 Synthesis and Characterization

    3.3 Conclusion


    4. Noble Metal-Based Plasmonic Nanoparticles for SERS Imaging and Photothermal Therapy

    Yulán Hernández, Betty C. Galarreta

    4.1 Introduction

    4.2 Plasmonic Properties of Metallic Nanoparticles

    4.3 Optical Hyperthermia

    4.4 Synthesis Methods

    4.5 Functionalization

    4.6 Theragnostics (SERS + PTT)

    4.7 Conclusion


    Further Reading

    5. Instrumentation for Magnetic Hyperthermia

    David Cabrera, Irene Rubia-Rodríguez, Eneko Garaio, Fernando Plazaola, Luc Dupré, Neil Farrow, Francisco J. Terán, Daniel Ortega

    5.1 Introduction

    5.2 Fundamental Aspects of Coil Design for MH

    5.3 Temperature Measurement in MH

    5.4 Commercial and Noncommercial Instrumentation to Measure SAR

    5.5 Conclusions and Perspectives



    6. Nanoscale Thermometry for Hyperthermia Applications

    Rafael Piñol, Carlos D.S. Brites, Nuno J. Silva, Luis D. Carlos, Angel Millán

    6.1 Introduction

    6.2 High Spatial Resolution Thermometry

    6.3 Luminescence Thermometry

    6.4 Intracellular Thermometry

    6.5 Intracellular Thermometry for Hyperthermia Studies

    6.6 Conclusions and Perspectives



    Further Reading

    7. High-Frequency Magnetic Response and Hyperthermia From Nanoparticles in Cellular Environments

    Neil Telling

    7.1 Introduction

    7.2 Measuring the High-Frequency Magnetic Response of Nanoparticles

    7.3 Magnetic Nanoparticles in Cellular Environments

    7.4 Summary and Future Perspectives




    8. Mechanisms of Cell Death Induced by Optical Hyperthermia

    Marta Pérez-Hernández

    8.1 Introduction

    8.2 Types of Cell Death

    8.3 Techniques to Determine the Type of Cell Death

    8.4 Cell Death Induced by PTT

    8.5 Conclusion


    9. Invertebrate Models for Hyperthermia:

    What We Learned From Caenorhabditis elegans and Hydra vulgaris

    Maria Moros, Laura Gonzalez-Moragas, Angela Tino, Anna Laromaine, Claudia Tortiglione

    9.1 Introduction to Animal Models in Nanoscience

    9.2 NP Fate and Status In Vivo

    9.3 Biological Effects of Heat

    9.4 Biological Effects of NPs

    9.5 Methodological Approaches for Tracking NPs Used for Optical and MHT in Hydra and C. elegans

    9.6 Conclusions


    Further Reading

    10. Image-Guided Thermal Therapy

    Using Magnetic Particle Imaging and

    Magnetic Fluid Hyperthermia

    Rohan Dhavalikar, Ana C. Bohórquez, Carlos Rinaldi

    10.1 Introduction

    10.2 Magnetic Fluid Hyperthermia

    10.3 Magnetic Particle Imaging

    10.4 Applications

    10.5 Combined MPI-MFH

    10.6 Conclusion



    11. Nanomaterials for Combined Thermo-Chemotherapy of Cancer

    Javier Idiago-López, Eduardo Moreno-Antolín, Raluca M. Fratila

    11.1 Introduction

    11.2 Magnetic Nanoparticle-Based Thermo-Chemotherapy

    11.3 Gold Nanoparticles as Thermo-Chemotherapeutic Agents

    11.4 Carbon-Based Nanomaterials for Cancer Thermo-Chemotherapy

    11.5 Conclusions and Perspectives











    12. A Roadmap to the Standardization of In Vivo Magnetic Hyperthermia

    Lilianne Beola, Lucía Gutiérrez, Valeria Grazú, Laura Asín

    12.1 Introduction

    12.2 Nanoparticle Design for MH In Vivo Application

    12.3 Nanoparticle Composition

    12.4 Magnetic Hyperthermia Conditions Used In Vivo

    12.5 Animal Models and Biological Effects

    12.6 Limitations and Future Challenges


    13. Current Good Manufacturing Practices (cGMPs) in the Commercial Development of Nanomaterials for Hyperthermia Applications

    Steven J. Oldenburg, Whitney N. Boehm, Karolina Sauerova, Thomas K. Darlington

    13.1 Introduction

    13.2 Good Manufacturing Practices

    13.3 Regulatory Classification of Nanomaterials

    13.4 Hyperthermia Products in Various Stages of Development

    13.5 Regulatory Strategy for Hyperthermia Products

    13.6 Quality Management Systems

    13.7 cGMP and Design Controls as a Framework for Project Success

    13.8 Conclusion


    Further Reading




    Conclusions: Magnetic and Optical Hyperthermia Using Nanomaterials—Limitations, Challenges and Future

    Raluca M. Fratila, Jesús M. de la Fuente



Product details

  • No. of pages: 384
  • Language: English
  • Copyright: © Elsevier 2018
  • Published: November 30, 2018
  • Imprint: Elsevier
  • Paperback ISBN: 9780128139288
  • eBook ISBN: 9780128139295

About the Editors

Raluca Fratila

Dr Raluca M. Fratila (Petrosani - Romania) obtained her PhD in Chemistry from the University “Politehnica” Bucharest (Romania) in 2005. She accomplished postdoctoral stays at the University of Basque Country, San Sebastian, Spain (2006–2008), and the University of Twente, Enschede, The Netherlands (2009–2013). In November 2013, she became a Marie Curie COFUND-ARAID researcher at the Institute of Nanoscience of Aragón (INA), University of Zaragoza, Spain. In 2015 she moved to the Aragon Materials Science Institute (University of Zaragoza, Spain) as a Marie Sklodowska-Curie researcher and since 2017 she is a Ramón y Cajal tenure-track researcher at the University of Zaragoza. Her research interests include bioorganic and bioorthogonal chemistry, magnetic resonance imaging (MRI), magnetic hyperthermia and biofunctionalization of magnetic nanoparticles for biomedical applications.

Affiliations and Expertise

Marie Skłodowska-Curie Researcher, Institute of Materials Science of Aragon (ICMA),University of Zaragoza, Spain

Jesús Martínez De La Fuente

Prof. Jesús Martínez de la Fuente is a Research Professor affiliated to the Institute of Nanoscience and Materials of Aragon, CSIC-University of Zaragoza and CIBER-BBN, in Spain. He created his own research group (BIONANOSURF Group) at the University of Zaragoza in 2007, becoming internationally recognized in nanomaterials and biofunctionalization. The multidisciplinary nature of the group facilitates research and development in numerous areas, including biosensors, gene therapy, magnetism, photochemistry, surface chemistry and molecular metal oxides, among others. Prof. Martínez de la Fuente has extensive experience in the synthesis and characterization of novel nanomaterials and their biofunctionalization for the use and development of the next generation of nanobiosensors and nanotherapeutics. In 2009, he founded the spin-off Nanoimmunotech SL. He has also been a pioneer in the application of gold nanoparticles in gene therapy and he has developed a methodology for the use of gold nanoparticles functionalized with carbohydrates (glyconanoparticles) for the study of biological processes (embryogenesis, cancer, inflammation, etc.). In 2010, he was awarded the Aragón Investiga "Young Researchers" prize, and in 2013, he was rewarded by the Shanghai Administration with the 1000 Talent Plan program to be a Visiting Professor at the Jiao Tong University of Shanghai. Since 2014, he is a permanent researcher at the Institute of Nanoscience and Materials of Aragon-CSIC and member of CIBER-BBN.

Affiliations and Expertise

Principal investigator, Nanotechnology and Apoptosis Group and Permanent Researcher, Spanish Research Council, Institute of Materials Science of Aragon, Spain

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