Nanomaterials for Magnetic and Optical Hyperthermia Applications

1st Edition - November 30, 2018
Editors: Raluca Maria Fratila, Jesús Martínez De La Fuente
Language: English
Paperback ISBN:
9 7 8 - 0 - 1 2 - 8 1 3 9 2 8 - 8
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 1 3 9 2 9 - 5

Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-… Read more

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Nanomaterials for Magnetic and Optical Hyperthermia Applications focuses on the design, fabrication and characterization of nanomaterials (magnetic, gold and hybrid magnetic-gold nanoparticles) for in vitro and in vivo hyperthermia applications, both as standalone and adjuvant therapy in combination with chemotherapy. The book explores the potential for more effective cancer therapy solutions through the synergistic use of nanostructured materials as magnetic and optical hyperthermia agents and targeted drug delivery vehicles, while also discussing the challenges related to their toxicity, regulatory and translational aspects. In particular, the book focuses on the design, synthesis, biofunctionalization and characterization of nanomaterials employed for magnetic and optical hyperthermia.

This book will be an important reference resource for scientists working in the areas of biomaterials and biomedicine seeking to learn about the potential of nanomaterials to provide hyperthermia solutions.

Contents

Contributors

Introduction to Hyperthermia

Raluca M. Fratila, Jesús M. de la Fuente

1 Hyperthermia as Therapeutic Approach

2 Hyperthermia at the Nanoscale—Why

Nanomaterials?

3 About This book

4 References

PRINCIPLES OF HYPERTHERMIA

1. Design Criteria of Thermal Seeds for Magnetic Fluid Hyperthermia From Magnetic Physics Point of View

Hiroaki Mamiya, Balachandran Jeyadevan

1.1 Introduction

1.2 Mechanism of Heat Generation

1.3 Operational Limits of Magnetic Field and Frequency Conditions

1.4 Novel Responses of Individual Magnetic

Nanoparticles to AC Magnetic Fields

1.5 Potential of Interacting MagneticNanoparticles

1.6 Summary and Perspectives

References

2. Design of Anisotropic Iron-Oxide-Based

Nanoparticles for Magnetic Hyperthermia

Geoffrey Cotin, Francis Perton, Cristina Blanco-Andujar, Benoit Pichon, Damien Mertz, Sylvie Bégin-Colin

2.1 Key Parameters Controlling the Generated Heat

2.2 Optimization of MH Properties of IONPs by Doping or Shape-Controlled Synthesis

2.3 Conclusion

References

3. Synthesis and Characterization of Magnetic–Plasmonic Hybrid Nanoparticles

Mari Takahashi, Ryoichi Kitaura, Priyank Mohan, Shinya Maenosono

3.1 Introduction

3.2 Synthesis and Characterization

3.3 Conclusion

References

4. Noble Metal-Based Plasmonic Nanoparticles for SERS Imaging and Photothermal Therapy

Yulán Hernández, Betty C. Galarreta

4.1 Introduction

4.2 Plasmonic Properties of Metallic Nanoparticles

4.3 Optical Hyperthermia

4.4 Synthesis Methods

4.5 Functionalization

4.6 Theragnostics (SERS + PTT)

4.7 Conclusion

References

Further Reading

5. Instrumentation for Magnetic Hyperthermia

David Cabrera, Irene Rubia-Rodríguez, Eneko Garaio, Fernando Plazaola, Luc Dupré, Neil Farrow, Francisco J. Terán, Daniel Ortega

5.1 Introduction

5.2 Fundamental Aspects of Coil Design for MH

5.3 Temperature Measurement in MH

5.4 Commercial and Noncommercial Instrumentation to Measure SAR

5.5 Conclusions and Perspectives

Acknowledgments

References

6. Nanoscale Thermometry for Hyperthermia Applications

Rafael Piñol, Carlos D.S. Brites, Nuno J. Silva, Luis D. Carlos, Angel Millán

6.1 Introduction

6.2 High Spatial Resolution Thermometry

6.3 Luminescence Thermometry

6.4 Intracellular Thermometry

6.5 Intracellular Thermometry for Hyperthermia Studies

6.6 Conclusions and Perspectives

Acknowledgments

References

Further Reading

7. High-Frequency Magnetic Response and Hyperthermia From Nanoparticles in Cellular Environments

Neil Telling

7.1 Introduction

7.2 Measuring the High-Frequency Magnetic Response of Nanoparticles

7.3 Magnetic Nanoparticles in Cellular Environments

7.4 Summary and Future Perspectives

References

CELLULAR RESPONSE TO HEAT

8. Mechanisms of Cell Death Induced by Optical Hyperthermia

Marta Pérez-Hernández

8.1 Introduction

8.2 Types of Cell Death

8.3 Techniques to Determine the Type of Cell Death

8.4 Cell Death Induced by PTT

8.5 Conclusion

References

9. Invertebrate Models for Hyperthermia:

What We Learned From Caenorhabditis elegans and Hydra vulgaris

Maria Moros, Laura Gonzalez-Moragas, Angela Tino, Anna Laromaine, Claudia Tortiglione

9.1 Introduction to Animal Models in Nanoscience

9.2 NP Fate and Status In Vivo

9.3 Biological Effects of Heat

9.4 Biological Effects of NPs

9.5 Methodological Approaches for Tracking NPs Used for Optical and MHT in Hydra and C. elegans

9.6 Conclusions

References

Further Reading

10. Image-Guided Thermal Therapy

Using Magnetic Particle Imaging and

Magnetic Fluid Hyperthermia

Rohan Dhavalikar, Ana C. Bohórquez, Carlos Rinaldi

10.1 Introduction

10.2 Magnetic Fluid Hyperthermia

10.3 Magnetic Particle Imaging

10.4 Applications

10.5 Combined MPI-MFH

10.6 Conclusion

Acknowledgment

References

11. Nanomaterials for Combined Thermo-Chemotherapy of Cancer

Javier Idiago-López, Eduardo Moreno-Antolín, Raluca M. Fratila

11.1 Introduction

11.2 Magnetic Nanoparticle-Based Thermo-Chemotherapy

11.3 Gold Nanoparticles as Thermo-Chemotherapeutic Agents

11.4 Carbon-Based Nanomaterials for Cancer Thermo-Chemotherapy

11.5 Conclusions and Perspectives

Acknowledgment

References

FROM BENCH TO

BEDSIDE—NANOMATERIAL

TOXICITY, REGULATORY

ASPECTS AND

CLINICAL PERSPECTIVES

OF MAGNETIC AND OPTICAL

HYPERTHERMIA

12. A Roadmap to the Standardization of In Vivo Magnetic Hyperthermia

Lilianne Beola, Lucía Gutiérrez, Valeria Grazú, Laura Asín

12.1 Introduction

12.2 Nanoparticle Design for MH In Vivo Application

12.3 Nanoparticle Composition

12.4 Magnetic Hyperthermia Conditions Used In Vivo

12.5 Animal Models and Biological Effects

12.6 Limitations and Future Challenges

References

13. Current Good Manufacturing Practices (cGMPs) in the Commercial Development of Nanomaterials for Hyperthermia Applications

Steven J. Oldenburg, Whitney N. Boehm, Karolina Sauerova, Thomas K. Darlington

13.1 Introduction

13.2 Good Manufacturing Practices

13.3 Regulatory Classification of Nanomaterials

13.4 Hyperthermia Products in Various Stages of Development

13.5 Regulatory Strategy for Hyperthermia Products

13.6 Quality Management Systems

13.7 cGMP and Design Controls as a Framework for Project Success

13.8 Conclusion

References

Further Reading

CONCLUSIONS AND

PERSPECTIVES

Conclusions: Magnetic and Optical Hyperthermia Using Nanomaterials—Limitations, Challenges and Future

Raluca M. Fratila, Jesús M. de la Fuente

Perspectives

Index

Raluca Maria Fratila

Dr Raluca M. Fratila (Petrosani - Romania) obtained her PhD in Chemistry from the University “Politehnica” Bucharest (Romania) in 2005. She accomplished postdoctoral stays at the University of Basque Country, San Sebastian, Spain (2006–2008), and the University of Twente, Enschede, The Netherlands (2009–2013). In November 2013, she became a Marie Curie COFUND-ARAID researcher at the Institute of Nanoscience of Aragón (INA), University of Zaragoza, Spain. In 2015 she moved to the Aragon Materials Science Institute (University of Zaragoza, Spain) as a Marie Sklodowska-Curie researcher and since 2017 she is a Ramón y Cajal tenure-track researcher at the University of Zaragoza. Her research interests include bioorganic and bioorthogonal chemistry, magnetic resonance imaging (MRI), magnetic hyperthermia and biofunctionalization of magnetic nanoparticles for biomedical applications.

Affiliations and expertise

Marie Skłodowska-Curie Researcher, Institute of Materials Science of Aragon (ICMA),University of Zaragoza, Spain

Jesús Martínez De La Fuente

Prof. Jesús Martínez de la Fuente is a Research Professor affiliated to the Institute of Nanoscience and Materials of Aragon, CSIC-University of Zaragoza and CIBER-BBN, in Spain. He created his own research group (BIONANOSURF Group) at the University of Zaragoza in 2007, becoming internationally recognized in nanomaterials and biofunctionalization. The multidisciplinary nature of the group facilitates research and development in numerous areas, including biosensors, gene therapy, magnetism, photochemistry, surface chemistry and molecular metal oxides, among others. Prof. Martínez de la Fuente has extensive experience in the synthesis and characterization of novel nanomaterials and their biofunctionalization for the use and development of the next generation of nanobiosensors and nanotherapeutics. In 2009, he founded the spin-off Nanoimmunotech SL. He has also been a pioneer in the application of gold nanoparticles in gene therapy and he has developed a methodology for the use of gold nanoparticles functionalized with carbohydrates (glyconanoparticles) for the study of biological processes (embryogenesis, cancer, inflammation, etc.). In 2010, he was awarded the Aragón Investiga "Young Researchers" prize, and in 2013, he was rewarded by the Shanghai Administration with the 1000 Talent Plan program to be a Visiting Professor at the Jiao Tong University of Shanghai. Since 2014, he is a permanent researcher at the Institute of Nanoscience and Materials of Aragon-CSIC and member of CIBER-BBN.

Affiliations and expertise

Principal investigator, Nanotechnology and Apoptosis Group and Permanent Researcher, Spanish Research Council, Institute of Materials Science of Aragon, Spain