Nanobioanalytical Approaches to Medical Diagnostics

Nanobioanalytical Approaches to Medical Diagnostics

1st Edition - June 15, 2022

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  • Editors: Pawan Maurya, Pranjal Chandra
  • eBook ISBN: 9780323851657
  • Paperback ISBN: 9780323851473

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Nanobioanalytical Approaches to Medical Diagnostics reviews a range of nanobiomaterials and bioanalytical nano-devices for medical diagnostics. Nanobiomaterials and nano-devices are used in various bioanalytical and biochemical systems to provide real-time, point-of-care diagnostics. The specialized properties of nanoparticles allow them to be engineered and adapted to produce the required effect within a bioanalytical or biochemical system – offering targeted and detailed diagnostic results in a range of biomedical applications. This book covers both traditional biochemical and modern, combined nano-approaches to medical diagnostics. Chapters detail a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including DNA and peptide-based, erythrocyte, microfluidic and more. In addition, sections also look at various different medical diagnostic applications, such as in cancer detection, infectious disease diagnosis and blood glucose sensing.

Key Features

  • Covers core principles and nano-approaches in bioanalytics for medical diagnostics
  • Details a range of in vitro, in vivo and ex vivo models for nanobioanalytics, including spectroscopic analysis, erythrocyte models, microfluidics, and more
  • Appeals to an interdisciplinary readership, spanning the fields of materials science, biomedical engineering and biochemical engineering


Academics and researchers in materials science, nanomedicine, biomedical engineering and chemical engineering. Also of interest to those working in medical diagnostics, both in industry and clinical settings

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Contributors
  • Preface
  • Chapter 1: Prospects of fluidic force microscopy and related biosensors for medical applications
  • Abstract
  • Acknowledgments
  • 1.1: Atomic force microscopy
  • 1.2: Cell biology with AFM
  • 1.3: Fluidic force microscopy
  • 1.4: Single-cell force spectroscopy by FluidFM
  • 1.5: Bacterial adhesion measured by FluidFM
  • 1.6: Eukaryotic cell adhesion
  • 1.7: Additional fluidic force microscopy functions
  • 1.8: Measurements by computer-controlled micropipette
  • 1.9: Label-free biosensors for cell adhesion analysis
  • 1.10: Summary
  • References
  • Chapter 2: Point of care diagnostics for cancer: Recent trends and challenges
  • Abstract
  • Acknowledgments
  • 2.1: Introduction
  • 2.2: Role of biomarkers in the detection of cancer
  • 2.3: Point-of-care diagnostics for cancer
  • 2.4: Conclusion and future perspectives
  • References
  • Chapter 3: Bioelectrochemical methods in biomolecular analysis
  • Abstract
  • 3.1: Introduction
  • 3.2: Types of bioelectrochemical methods for bimolecular analysis: Working mechanism
  • 3.3: Application of bioelectrochemical system based biosensor
  • 3.4: Bioelectrochemical methods for cell analysis
  • 3.5: Bioelectrochemical methods for cell analysis
  • 3.6: Bioelectrochemical methods for cell culture fabrication and cell stimulation
  • 3.7: Prospective and future trends
  • References
  • Chapter 4: Electrochemical nano-aptasensor as potential diagnostic device for thrombin
  • Abstract
  • 4.1: Introduction
  • 4.2: Aptasensor
  • 4.3: Thrombin
  • 4.4: Application of electrochemical aptasensors in thrombin detection
  • 4.5: Conclusions and future outlook
  • References
  • Chapter 5: Antibiotics and analytical methods used for their determination
  • Abstract
  • 5.1: Introduction
  • 5.2: Antibacterial drugs and the extent of their use
  • 5.3: Conclusion
  • References
  • Chapter 6: Integration of microfluidics with biosensing technology for noncommunicable disease diagnosis
  • Abstract
  • 6.1: Introduction
  • 6.2: Biosensor technology
  • 6.3: Microfluidics technology
  • 6.4: Microfluidics-based biosensors
  • 6.5: Communication technology
  • 6.6: Conclusion
  • References
  • Chapter 7: Role and implication of nanomaterials in clinical diagnostics
  • Abstract
  • Acknowledgments
  • 7.1: Introduction
  • 7.2: Nanomaterials in bioimaging based diagnostics
  • 7.3: Nanodevices
  • 7.4: Nano-biosensors
  • 7.5: Lateral flow assay
  • 7.6: Safety concerns and limitations of using nanoparticle
  • 7.7: Conclusion and future prospects
  • References
  • Chapter 8: Nano-materials in biochemical analysis
  • Abstract
  • 8.1: Introduction
  • 8.2: Classification of nanoparticles
  • 8.3: Synthesis of nanoparticles
  • 8.4: Functionalization of nanomaterials for biochemical applications
  • 8.5: Biochemical applications of nanoparticles
  • 8.6: Conclusion and future prospects
  • References
  • Chapter 9: Lignocellulose-based nanomaterials for diagnostic and therapeutic applications
  • Abstract
  • 9.1: Introduction
  • 9.2: Lignocellulose and its composition
  • 9.3: Nanoparticles from lignocellulose
  • 9.4: Biomedical applications of LCB nanomaterials
  • 9.5: Conclusion and future prospects
  • References
  • Chapter 10: Bioanalytical approaches in detection of free radicals and RONS
  • Abstract
  • 10.1: Introduction
  • 10.2: Overview of ROS detection methods
  • 10.3: Conventional ex vivo bioanalytical methods
  • 10.4: Conventional in vivo methods
  • 10.5: Advance methods for radical/RNOS detection
  • 10.6: Conclusion
  • References
  • Chapter 11: Nano-biosensors for biochemical analysis
  • Abstract
  • Acknowledgments
  • 11.1: Introduction
  • 11.2: Biosensors
  • 11.3: AuNP-based biosensors
  • 11.4: Carbon nanotube based biosensors
  • 11.5: Quantum dots based biosensors
  • 11.6: Nanoparticles in analytical biochemistry
  • 11.7: Nanoparticles in bioassays
  • 11.8: Applications
  • 11.9: Conclusion and future perspectives
  • References
  • Chapter 12: Nanobiomaterials in biomedicine: Designing approaches and critical concepts
  • Abstract
  • 12.1: Introduction
  • 12.2: Nanomaterials and it's applications in nanomedicine
  • 12.3: Nanoparticles used in drug delivery system
  • 12.4: Conclusion
  • References
  • Chapter 13: Erythrocytes model for oxidative stress analysis
  • Abstract
  • Authors contributions
  • 5.1: Oxidative stress
  • 5.2: Oxidative stress and diseases
  • 5.3: Oxidative stress and autoimmune diseases
  • 5.4: Oxidative stress and rheumatoid arthritis
  • 5.5: Oxidative stress and erythrocytes
  • 5.6: Conclusion
  • References
  • Chapter 14: Lipid film based biosensors: A protection tool for the public health
  • Abstract
  • 14.1: Introduction
  • 14.2: Construction of lipid film based nanosensors
  • 14.3: Applications of lipid film based biosensors in clinical analysis for the protection of public health
  • 14.4: Conclusion
  • References
  • Index

Product details

  • No. of pages: 426
  • Language: English
  • Copyright: © Woodhead Publishing 2022
  • Published: June 15, 2022
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780323851657
  • Paperback ISBN: 9780323851473

About the Editors

Pawan Maurya

Prof. Pawan Kumar Maurya is Dean, School of Life Long Learning & Head of Department of Biochemistry, Central University of Haryana, India. He has done a PhD from the University of Allahabad (A Central University), India & post-doctoral training from Universidade Federal de Sao Paulo-UNIFESP, Brazil; Taipei Medical University (TMU) and National Taiwan University (NTU), Taiwan. He has more than 14 years of teaching and research experience. He is working on biochemical diagnostics, nanomedicine, and clinical biochemistry. He has published over 75 research articles in reputed journals. He has also edited of six books published from Elsevier, USA and Springer-Nature, Singapore. He is recipient of prestigious fellowships: Science without Borders (Government of Brazil) and National Science Council, Taiwan.

Affiliations and Expertise

Central University of Haryana, Mahendergarh (Haryana), INDIA

Pranjal Chandra

Dr. Pranjal Chandra earned his Ph.D. from Pusan National University, South Korea and did post-doctoral training at Technion-Israel Institute of Technology, Israel. He has published over 85 research articles in reputed journals and 7 books. He is also a visiting scientist/Professor at IBST, South Korea. Pranjal's research contributions are highly interdisciplinary, spanning a wide range in nanobiotechnology, nanobiosensors, lab-on-chip systems for biomedical diagnostics, and nanomedicine. His work has been highlighted in the World news of Royal Society of Chemistry, Cambridge as "A new system for cancer detection” and also featured as a key scientific article in the Global Medical Discovery news Canada. He is recipient of many prestigious awards and fellowships such as; Ramanujan fellowship and Early Career Research Award (Government of India), BK -21 and NRF fellowship of South Korea, Technion post-doctoral fellowship, Israel, University of Montreal Post-doc fellowship, Canada, NMS Young scientist Award (2016) etc. He is also editorial board member of a dozen international journals including; World journal of methodology, USA; Frontiers of Biosciences, USA; Journal of Biosensors and Bioelectronics, USA etc.

Affiliations and Expertise

Assistant Professor and principal investigator, School of Biochemical Engineering Indian Institute of Technology (BHU), Varanasi - Uttar Pradesh 221005, India

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