Musculoskeletal Tissue Engineering

Musculoskeletal Tissue Engineering

1st Edition - November 4, 2021

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  • Editor: Yupeng Chen
  • Paperback ISBN: 9780128238936
  • eBook ISBN: 9780128242100

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Description

Musculoskeletal Tissue Engineering introduces the fundamental concepts and translational applications of musculoskeletal tissue engineering, in combination with emerging technologies and materials. Sections discuss Tissues and Technologies, covering a range of musculoskeletal tissues, including bone, cartilage, ligament and more. Each chapter in this section details core tissue engineering principles specific to each tissue type. Next, a Technologies section looks at the range of biomaterials used in musculoskeletal tissue engineering, focusing on biocompatibility of materials and interactions at the material-tissue interface. Other chapters cover nanotechnology, 3D printing, gene therapy, tissue chips, and more. This book offers an advanced reference text for researchers in biomedical engineering, materials science and regenerative medicine.

Key Features

  • Details various materials and cutting-edge technologies for musculoskeletal tissue engineering
  • Covers a range of musculoskeletal tissues, including bone, cartilage, ligament, tendon, meniscus, and more
  • Provides a balance between basic concepts and translational applications for a broad audience

Readership

Academics and researchers in materials science, biomedical engineering and regenerative medicine, with an interest in the musculoskeletal system

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Dedication
  • List of contributors
  • Preface
  • Further reading
  • Chapter 1. Bone tissue engineering
  • Abstract
  • 1.1 Current strategies for bone repair
  • 1.2 Bone tissue engineering
  • 1.3 Contemporary topics in bone regeneration
  • 1.4 Outlook
  • References
  • Chapter 2. Cartilage tissue engineering
  • Abstract
  • 2.1 Development history of cartilage tissue engineering
  • 2.2 Cells for cartilage repair and tissue engineering
  • 2.3 Signaling molecules related to cartilage regeneration
  • 2.4 Biomaterials applied for cartilage tissue engineering
  • 2.5 Limitations and development potential in cartilage tissue engineering
  • References
  • Chapter 3. Skeletal muscle tissue engineering
  • Abstract
  • 3.1 Structure and function of skeletal muscle
  • 3.2 Regenerative ability of skeletal muscle
  • 3.3 Overview of skeletal muscle tissue engineering
  • 3.4 Cells
  • 3.5 Scaffolds
  • 3.6 Growth factors
  • 3.7 Clinical implications and utility
  • 3.8 Future directions and conclusion
  • References
  • Chapter 4. Ligament and tendon tissue engineering
  • Abstract
  • 4.1 Structure and function of tendon and ligaments
  • 4.2 Chronic degeneration of tendon and ligament
  • 4.3 Tendon/ligament injury and repair
  • 4.4 Tendon/ligament healing and complications
  • 4.5 The cellular landscape of diseased tendon to inform tissue engineering
  • 4.6 Types of cells used for tendon tissue engineering
  • 4.7 Tendon cell heterogeneity
  • 4.8 Biomaterial approaches for tendon and ligament tissue engineering
  • 4.9 Natural materials
  • 4.10 Synthetic materials
  • 4.11 Utilizing regenerative models of healing to inform tendon/ligament tissue engineering
  • 4.12 Future perspectives to enhance tendon and ligament tissue engineering
  • References
  • Chapter 5. Meniscus tissue engineering and repair
  • Abstract
  • 5.1 Introduction
  • 5.2 Clinical significance of meniscus injuries
  • 5.3 Clinical and preclinical treatments for meniscus injury and replacement
  • 5.4 Conclusion
  • References
  • Chapter 6. Functions and applications of extracellular matrix in cartilage tissue engineering
  • Abstract
  • 6.1 Introduction
  • 6.2 Molecular function and assembly of cartilage extracellular matrix
  • 6.3 Pericellular matrix in cartilage function and disease
  • 6.4 Direct applications of extracellular matrix in cartilage regeneration
  • 6.5 Conclusions and outlook
  • References
  • Chapter 7. 3D printing for soft musculoskeletal tissue engineering
  • Abstract
  • 7.1 Introduction
  • 7.2 3D bioprinting for skeletal muscle tissue engineering
  • 7.3 Future outlook and conclusions
  • Acknowledgments
  • References
  • Chapter 8. A review on the 3D printing of composite scaffolds for bone tissue engineering
  • Abstract
  • 8.1 Introduction
  • 8.2 Desirable scaffold properties for bone tissue engineering
  • 8.3 Biocompatibility
  • 8.4 Scaffold architecture
  • 8.5 Mechanical properties
  • 8.6 Controlled biodegradability
  • 8.7 Bioactivity
  • 8.8 Three-dimensional printing methods for fabricating bone scaffolds
  • 8.9 Materials and composite materials used in bone tissue engineering
  • 8.10 Future direction
  • References
  • Chapter 9. Mechano-active materials for musculoskeletal tissue engineering
  • Abstract
  • 9.1 Introduction
  • 9.2 Rationale of mechano-active biomaterials for tissue engineering
  • 9.3 Mechano-active biomaterials for intervertebral disk tissue engineering
  • 9.4 Mechano-active biomaterials for osteochondral tissue engineering
  • 9.5 Mechano-active biomaterials for skeletal muscle tissue engineering
  • 9.6 Summary and outlook
  • 9.7 Acknowledgments
  • References
  • Chapter 10. Musculoskeletal tissue chips
  • Abstract
  • 10.1 The musculoskeletal system
  • 10.2 General musculoskeletal diseases and statistics
  • 10.3 2D cell culture to 3D cell culture
  • 10.4 Types of cell culture
  • 10.5 Musculoskeletal tissue chips
  • 10.6 Conclusion
  • References
  • Further reading
  • Chapter 11. Drug and gene delivery for musculoskeletal tissues
  • Abstract
  • 11.1 Introduction
  • 11.2 Therapeutic drugs and genes for musculoskeletal diseases
  • 11.3 Delivery strategies
  • 11.3 Conclusion
  • 11.4 Future
  • References
  • Chapter 12. Stem cells and regenerative medicine for musculoskeletal tissue
  • Abstract
  • 12.1 The clinical impact of bone fractures
  • 12.2 Fracture healing process
  • 12.3 Fracture healing and progenitor cells
  • 12.4 Signaling pathways in bone repair
  • 12.5 Biomaterials in bone regeneration
  • 12.6 Conclusion
  • References
  • Index

Product details

  • No. of pages: 382
  • Language: English
  • Copyright: © Elsevier 2021
  • Published: November 4, 2021
  • Imprint: Elsevier
  • Paperback ISBN: 9780128238936
  • eBook ISBN: 9780128242100

About the Editor

Yupeng Chen

Professor Yupeng Chen is an Associate Professor in the Department of Biomedical Engineering at the University of Connecticut. He received his bachelor degree from Fudan University and pursued his Masters degree in biomedical engineering and Ph.D. in nanomaterials and nanomedicine at Brown University. Prof. Chen has a long-term interest in translating advances from nanotechnology into clinical applications. In particular, he focuses on engineering self-assembled Janus-base nanotubes into various non-covalent architectures for musculoskeletal tissue engineering. Prof. Chen also serves as the Principal Investigator of several competitive research grants from NIH and NSF. Prof. Chen has won several prestige awards, including the Faculty Early Career Development (CAREER) Award from NSF in 2017 and the New Investigator Recognition Award from Orthopaedic Research Society in 2013 (he was the top-one awardee selected from 545 applicants all over the world). Prof. Chen also served as a reviewer for NIH musculoskeletal tissue engineering (MTE) study section multiple times and served as the chair of the musculoskeletal tissue engineering session in 2019 BMES annual meeting.

Affiliations and Expertise

Associate Professor, University of Connecticut, Connecticut, USA

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