Murray & Nadel's Textbook of Respiratory Medicine, 2-Volume Set - 6th Edition - ISBN: 9781455733835, 9780323340717

Murray & Nadel's Textbook of Respiratory Medicine, 2-Volume Set

6th Edition

Editors: V.Courtney Broaddus Joel Ernst Talmadge E King, Jr Stephen Lazarus
Authors: Robert Mason Arthur Slutsky John Murray Jay Nadel Michael Gotway
Hardcover ISBN: 9781455733835
eBook ISBN: 9780323340717
eBook ISBN: 9780323261937
Imprint: Elsevier
Published Date: 23rd March 2015
Page Count: 2064

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Ideal for fellows and practicing pulmonologists who need an authoritative, comprehensive reference on all aspects of pulmonary medicine, Murray and Nadel’s Textbook of Respiratory Medicine offers the most definitive content on basic science, diagnosis, evaluation and treatment of the full spectrum of respiratory diseases. Included with your print purchase is the Expert Consult eBook version, which offers content updates, videos, review questions, and Thoracic Imaging Cases (TICs), all of which are easily navigable on any device for access on rounds or in the clinic. The embedded videos cover thoracoscopy, therapeutic bronchoscopy, volumetric chest CT scans, and more, while brand-new audio files highlight normal and abnormal breath sounds and the separate components of cough.

Key Features

  • Full-color design enhances teaching points and highlights challenging concepts.
  • Understand clinical applications and the scientific principles of respiratory medicine.
  • Detailed explanations of each disease entity allow you to work through differential diagnoses.

Table of Contents



SECTION A: Anatomy and Development of the Respiratory Tract

1 Anatomy of the Lungs

2 Lung Growth and Development

3 Genetics of Lung Disease

SECTION B: Respiratory Physiology

4 Ventilation, Blood Flow, and Gas Exchange

5 Respiratory System Mechanics and Energetics

6 Pulmonary Circulation and Regulation of Fluid Balance

7 Acid-Base Balance

SECTION C: Defense Mechanisms and Immunology

8 Alveolar Epithelium and Pulmonary Surfactant

9 Alveolar Epithelium and Fluid Transport

10 Airway Epithelium and Mucous Secretion

11 Aerosol Deposition and Clearance

12 Innate Immunity

13 Adaptive Immunity

SECTION D: Respiratory Pathology and Inflammation

14 Pathology: Malignant and Interstitial Lung Diseases

15 Injury and Repair


SECTION E: Diagnosis

16 History and Physical Examination

17 Microbiologic Diagnosis of Lung Infection

18 Thoracic Radiology: Noninvasive Diagnostic Imaging

19 Thoracic Radiology: Invasive Diagnostic Imaging and Image-Guided Interventions

20 Ultrasonography

21 Positron Emission Tomography

22 Diagnostic Bronchoscopy

23 Therapeutic Bronchoscopy

24 Thoracoscopy

SECTION F: Evaluation

25 Pulmonary Function Testing

26 Clinical Exercise Testing

27 Preoperative Evaluation

28 Evaluation of Respiratory Impairment and Disability


SECTION G: Symptoms of Respiratory Disease and Their Management

29 Dyspnea

30 Cough

31 Chest Pain

SECTION H: Infectious Diseases of the Lungs

32 Viral Infections

33 Bacterial Pneumonia and Lung Abscess

34 Ventilator-Associated Pneumonia

35 Tuberculosis

36 Nontuberculous Mycobacterial Infections

37 Endemic Mycoses

38 Opportunistic Mycoses

39 Parasitic Infections

40 Bioterrorism

SECTION I: Obstructive Diseases

41 Asthma: Pathogenesis and Phenotypes

42 Asthma: Clinical Diagnosis and Management

43 COPD: Pathogenesis and Natural History

44 COPD: Clinical Diagnosis and Management

45 Genetics in Asthma and COPD

46 Smoking Hazards and Cessation

47 Cystic Fibrosis

48 Bronchiectasis

49 Upper Airway Disorders

50 Bronchiolitis and Other Intrathoracic Airway Disorders


SECTION J: Neoplasms of the Lung

51 Biology of Lung Cancer

52 Epidemiology of Lung Cancer

53 Clinical Aspects of Lung Cancer

54 Rare Primary Lung Tumors

55 Metastatic Malignant Tumors

56 Benign Lung Tumors

SECTION K: Disorders of the Pulmonary Circulation

57 Pulmonary Thromboembolism

58 Pulmonary Hypertension

59 Pulmonary Hypertension due to Lung Disease

60 Pulmonary Vasculitis

61 Pulmonary Vascular Abnormalities

62 Pulmonary Edema

SECTION L: Infiltrative and Interstitial Lung Diseases

63 Idiopathic Interstitial Pneumonias

64 Hypersensitivity Pneumonitis

65 Connective Tissue Diseases

66 Sarcoidosis

67 Alveolar Hemorrhage and Rare Infiltrative Diseases

68 Eosinophilic Lung Diseases

69 Lymphangioleiomyomatosis

70 Pulmonary Alveolar Proteinosis Syndrome

71 Drug-Induced Pulmonary Disease

SECTION M: Environmental and Occupational Hazards

72 Asthma in the Workplace

73 Pneumoconioses

74 Indoor and Outdoor Air Pollution

75 Acute Responses to Toxic Exposures

76 Trauma and Blast Injuries

77 High Altitude

78 Diving Medicine

SECTION N: Disorders of the Pleura

79 Pleural Effusion

80 Pleural Infections

81 Pneumothorax, Chylothorax, Hemothorax, and Fibrothorax

82 Pleural Tumors

SECTION O: Disorders of the Mediastinum

83 Mediastinal Tumors and Cysts

84 Pneumomediastinum and Mediastinitis

SECTION P: Disorders of Sleep and Control of Breathing

85 Control of Breathing and Upper Airways During Sleep

86 Hypocapnia and Hypercapnia

87 Consequences of Sleep Disruption

88 Obstructive Sleep Apnea

89 Central Sleep Apnea

SECTION Q: Respiratory Manifestations of Extrapulmonary Disorders

90 Pulmonary Complications of HIV Infection

91 Pulmonary Complications of Stem Cell and Solid Organ Transplantation

92 Pulmonary Complications of Primary Immunodeficiencies

93 Pulmonary Complications of Abdominal Diseases

94 Pulmonary Complications of Hematologic Diseases

95 Pulmonary Complications of Endocrine Diseases

96 The Lungs in Obstetric and Gynecologic Diseases

97 The Respiratory System and Neuromuscular Diseases

98 The Respiratory System and Chest Wall Diseases

SECTION R: Management of Respiratory Failure

99 Acute Ventilatory Failure

100 Acute Hypoxemic Respiratory Failure and ARDS

101 Mechanical Ventilation

102 Noninvasive Ventilation

103 Extracorporeal Support of Gas Exchange

104 End-of-Life Care in Respiratory Failure

105 Pulmonary Rehabilitation

106 Lung Transplantation


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About the Editor

V.Courtney Broaddus

Affiliations and Expertise

John F. Murray Distinguished Professor of Medicine, University of California, San Francisco; Chief, Division of Pulmonary and Critical Care Medicine, San Francisco General Hospital, San Francisco, California

Joel Ernst

Affiliations and Expertise

Director, Division of Infectious Diseases and Immunology, Jeffrey Bergstein Professor of Medicine, Professor of Medicine, Pathology and Microbiology, New York University School of Medicine, NYU Langone Medical Center, New York, New York

Talmadge E King, Jr

Affiliations and Expertise

Julius R. Krevans Distinguished Professorship in Internal Medicine, Chair, Department of Medicine, University of California San Francisco, San Francisco, California

Stephen Lazarus

Affiliations and Expertise

Professor of Medicine, Division of Pulmonary & Critical Care Medicine, Director, Clinical Training Program in Pulmonary & Critical Care Medicine, Associate Director, Adult Pulmonary Laboratory, Senior Investigator, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California

About the Author

Robert Mason

Affiliations and Expertise

Cetalie & Marcel Weiss Chair in Pulmonary Medicine, Department of Medicine, National Jewish Health, Denver, Colorado; Professor of Medicine, University of Colorado Denver Health Sciences Center, Aurora, Colorado

Arthur Slutsky

Affiliations and Expertise

Keenan Chair in Medicine, Professor of Medicine, Surgery and Biomedical Engineering, University of Toronto; Vice President (Research), St Michael's Hospital, Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, Toronto, Ontario, Canada

John Murray

Professor Emeritus, Department of Medicine, University of California San Francisco, San Francisco, California

Affiliations and Expertise

Professor Emeritus of Medicine, University of California San Francisco, San Francisco General Hospital, San Francisco, CA

Jay Nadel

Affiliations and Expertise

Professor of Medicine, Physiology, and Radiology, Division of Pulmonary and Critical Care Medicine, Cardiovascular Research Institute, University of California San Francisco, San Francisco, California

Michael Gotway

Affiliations and Expertise

Professor of Radiology, Mayo Clinic, Scottsdale, AZ; Clinical Associate Professor, Diagnostic Radiology / Biomedical Imaging & Pulmonary / Critical Care Medicine, Department of Radiology, University of California, San Francisco, San Francisco, California; Clinical Professor, University of Arizona College of Medicine, Phoenix, AZ; Adjunct Professor, Department of Biomedical Informatics, Arizona State University, Tempe, AZ