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Multiscale Biomechanical Modeling of the Brain - 1st Edition - ISBN: 9780128181447

Multiscale Biomechanical Modeling of the Brain

1st Edition

Authors: Raj Prabhu Mark Horstemeyer
Paperback ISBN: 9780128181447
Imprint: Academic Press
Published Date: 1st November 2021
Page Count: 200
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Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection.

The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels.

Key Features

  • Presents concepts in a theoretical and thermodynamic framework for each length scale
  • Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model
  • Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems


Academics, engineers, clinicians and researchers in the fields of biomechanics, biomedical engineering, mechanical engineering and head trauma. Undergraduate and graduate students in biomedical/biological engineering, mechanical engineering and neurotrauma areas, academics, clinicians, and researchers in sports medical sciences and engineering, and rehabilitation

Table of Contents

  1. Introduction to multiscale modeling
    2. Downscaling (Macroscale to nanoscale) multiscale paradigm -Discuss on things related damage/strength, stiffness, vibrations/resonance -Temperature, strain rate and stress state -Fatigue, creep and overloads
    3. DFT; Electronics for organic molecules
    4. Nanoscale Atomistics and Molecular Dynamics
    5. Microscale Mechano-Physiological Modeling and Coarse-Grain Molecular Dynamics
    6. Mesoscale Finite Element Modeling
    7. Macroscale Thermodynamic Framework and Modeling
    8. Structural Scale - Brain’s VUmat file calibration, and validation - Blast Finite Element Simulations (high rate) -Blunt Impact Simulations (intermediate rate) - Car Crash Simulations (intermediate rate)
    9. Robust Multi-objective design and optimization
    10. Summary and conclusions


No. of pages:
© Academic Press 2021
1st November 2021
Academic Press
Paperback ISBN:

About the Authors

Raj Prabhu

Deputy Project Scientist, NASA HRP Cross-Cutting Computational Modeling Project at UNIVERSITIES SPACE RESEARCH ASSOCIATION His research is focused on studying Traumatic Brain Injury (TBI) through high strain rate Split-Hopkinson bar experiments on the brain and Finite Element (FE) simulations of the brain under large strains and blast related scenarios. MSU recognized his PhD work by awarding him graduate student researcher of the year (2010-2011) award. In the current position, he leads the modeling and simulation efforts within the ABE\\\'s HumanBodySim research group. The HumanBodySim group is highly interdisciplinary and includes doctoral students, Post-Docs and faculty members who specialize in material science, computational solid engineering and biomedical engineering. Dr. Prabhu is also involved in teaching graduate level continuum mechanics, undergraduate level biomedical engineering design courses.

Affiliations and Expertise

Deputy Project Scientist, NASA HRP Cross-Cutting Computational Modeling Project, Universities Space Research Association

Mark Horstemeyer

CAVS Chair Professor, Department of Mechanical Engineering, Mississippi State University Dr. Horstemeyer has published over 350 journal articles, conference papers, books, and technical reports. He has won many awards including the R&D 100 Award, AFS Best Paper Award, Sandia Award for Excellence, the SAE Teetor Award and was a consultant for the Columbia Accident Investigation Board. He is a fellow of the American Society of Mechanical Engineers, the American Society of Metals, the American Association for the Advancement of Science, and the Society of Automotive Engineers. Before coming to MSU, he worked at Sandia National Laboratories for 15 years where he worked on a myriad of projects mostly focusing on weapons programs but transferred the research and technologies developed at Sandia to the automotive industry.

Affiliations and Expertise

CAVS Chair Professor, Department of Mechanical Engineering, Mississippi State University

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