This volume will be a collection of chapters from authors with wide experience in their research field. The purpose is to produce a coherent book that reflects the common theme of theory in medical thinking and multidisciplinary research practice. In this context "theory" relates to frameworks of concepts, facts, models etc that help to inform practitioners (clinicians, scientists and engineers) both within their own fields and as they seek to share dialogue with colleagues from other fields. The book will therefore be integrative across a broad spectrum of fields within medicine. To achieve this the chapters will be associated with others in a number of meaningful ways. Each chapter will share a number of points of contact that will include at least two of the following: *similar biomedical area (e.g., immunity, neuroscience, endocrinology, pathology, oncology, haematology, …) *similar multidisciplinary theoretical contexts (e.g., modelling, analysis, description, visualization, complex systems, …) *similar multidisciplinary medical issues and questions (e.g., clinical practice, decision making, informatics, …)

Key Features

· Uniquely explores role of interdisciplinary exchange in the development and expansion of medical theory · Timely and insightful essays on the growth and development of medical theories from some of the world's top clinicians and medical researchers, including Werner Arber, Frank Vertosick, and David Weatherall · Assembles diverse perspectives on medicine and physiology from biology, statistics, ethics, computer science, philosophy, history · Uniquely illuminates the social and historical processes through which theoretical research translates into clinical practice · Reveals the growing role of technology, especially computational modelling, in changing the nature of Western medicine


Professionals interested in representing information in a visual manner, leveraging models used across multiple disciplines

Table of Contents

Foreword 1. Disorders of Haemoglobin: From Phenotype to Genotype 2. Between Bleeding and Thrombosis or Beyond 3. The Theory of Molecular Evolution and its Medical Implications 4. What is a Medical Theory? 5. Medicine as a Moral Epistemology 6. Theory in Medical Education: An Oxymoron? 7. Knowledge, Arguments, and Intentions in Clinical Decision-Making 8. Analogies, Conventions and Expert Systems in Medicine: Some Insights from a XIX 9. Reliability of Measurements in Medical Research and Clinical Practice 10. Advanced Data Mining and Predictive Modeling at the Core of Personalized Medicine 11. Designs and Therapies for Stochastic Neural Systems 12. Mining Scenarios for Hepatitis B and C 13. Modeling the In Vivo Growth Rate of HIV: Implications for Vaccination 14. A Flexible, Iterative Approach to Physiological Modelling 15. System Biology, Cell Specificity and Physiology 16. Modelling T Cell Activation, Proliferation and Homeostasis 17. A Theory for Complex Systems: Reactive Animation 18. Modelling of Haemodynamics in the Cardiovascular System by Integrating Medical Imaging Techniques and Computer Modelling Tools 19. Vasopressin and Homeostasis – Running Hard to Stay in the Same Place 20. Mathematical Modelling of Angiogenesis and Vascular Adaptation 21. Towards Understanding the Physical Basis of Re-entrant Cardiac Arrhythmias


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© 2005
Elsevier Science
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About the series-volume-editors

Ray Paton

Affiliations and Expertise

Department of Computer Science, University of Liverpool, UK

Laura McNamara

Affiliations and Expertise

Exploratory Simulation Technologies, Sandia National Laboratories, Albuquerque, New Mexico, USA