Movement Disorders

2nd Edition

Genetics and Models

Editors: Mark LeDoux
Hardcover ISBN: 9780124051959
eBook ISBN: 9780124055162
Imprint: Academic Press
Published Date: 15th September 2014
Page Count: 1258
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The use of animal models is a key aspect of scientific research in numerous fields of medicine. Movement Disorders, Second Edition vigorously examines the important contributions and application of animal models to the understanding of human movement disorders, and serves as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders.

A vital feature of this book is an ancillary website with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson's disease, Huntington's disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration, and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

Key Features

  • Introduces the scientific foundations for modern movement disorders research
  • Contributing authors are internationally known experts
  • Completely revised with 20% new material
  • Provides a comprehensive discussion of genetics for each type of movement disorder
  • Covers Parkinson's disease, Huntington's disease, dystonia, tremors, and tics
  • Supported by a video library of movement disorders in patients with associated animal models hosted on a companion website


General neurologists, neurologists with subspecialty interest in movement disorders, neuroscientists, rehabilitation physicians, psychiatrists, and academic veterinarians with an interest in animal models.

Table of Contents

  • Foreword
  • Preface
  • <li>Section I. Scientific Foundations<ul><li>Chapter 1. Taxonomy and Clinical Features of Movement Disorders<ul><li>1.1. Introduction</li><li>1.2. Parkinson Disease</li><li>1.3. Essential Tremor</li><li>1.4. Huntington Disease and Other Choreiform Disorders</li><li>1.5. Dystonia</li><li>1.6. Wilson Disease</li><li>1.7. Myoclonus</li><li>1.8. Gilles de la Tourette Syndrome</li><li>1.9. Drug-Induced Movement Disorders</li><li>1.10. Hemiballism</li><li>1.11. Summary</li></ul></li><li>Chapter 2. Modeling Disorders of Movement<ul><li>2.1. Scientific Application of Animal Models</li><li>2.2. Choice of the Appropriate Animal Model</li><li>2.3. Experimental Approaches</li><li>2.4. Disorder-Specific Animal Models</li></ul></li><li>Chapter 3. New Transgenic Technologies<ul><li>3.1. Genome Modification</li><li>3.2. Inducible Transgenes and Conditional Alleles</li><li>3.3. Applications of Transgenic Technology and Transgene Design</li><li>3.4. New Technologies: The Advent of Nucleases</li><li>3.5. Avoiding Experimental Snares in Animal Model Research</li><li>3.6. Future Prospects</li></ul></li><li>Chapter 4. Assessment of Movement Disorders in Rodents<ul><li>4.1. Introduction</li><li>4.2. Basic Concepts of Animal Modeling</li><li>4.3. Specific Tests for Motor Abnormalities</li><li>4.4. Global Strategies for Assessing Movement Disorders</li><li>4.5. Suggested Test Batteries for Specific Movement Disorders</li><li>4.6. Summary</li></ul></li><li>Chapter 5. Drosophila<ul><li>5.1. Introduction: A Historical Perspective on Flies and Genetic Disease Research</li><li>5.2. Basics of Genetic Analysis</li><li>5.3. Genes, Genome, and Homologies</li><li>5.4. Nervous System Organization</li><li>5.5. Detecting Movement Abnormalities</li><li>5.6. Genetic Tools of the Trade</li><li>5.7. Applications of the <i>Drosophila</i> Model in Movement Disorder Research</li><li>5.8. Prospects for the Future</li></ul></li><li>Chapter 6. Use of <i>Ca


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About the Editor

Mark LeDoux

Mark S. LeDoux, MD, PhD is a physician-scientist at the University of Tennessee Health Science Center. At present he holds a joint appointment as Professor in the Departments of Neurology, and Anatomy and Neurobiology. He specializes in the neurological subspecialty of movement disorders and treats patients at the University of Tennessee Medical Group and Memphis VA hospital. As an active clinical researcher, Dr. LeDoux’s work has focused on the genetics and treatment of dystonia, Parkinson disease and Huntington disease. He has described Huntington disease in a nonagenarian and reported one of the world’s largest pedigrees with HDL2. In the laboratory, Dr. LeDoux has published extensively on the genetics and molecular biology of dystonia, mechanisms of cell death in Parkinson’s disease, animal models of dystonia and autism, and the neuroanatomy of motor systems. His work with the dt rat engendered paradigm shifts in dystonia and motor systems research. Dr. LeDoux’s lab showed that familial and sporadic adult-onset primary dystonia may be associated with rare sequence variants in THAP1 and CIZ1.

Affiliations and Expertise

Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA


BMA Medical Book Awards 2015: Highly Commended, Neurology, British Medical Association


Praise for the first edition:

"The book is a timely review of animal models of movement disorders...The text is an excellent resource for neurologists and researchers specializing in movement disorders. In addition, this book will undoubtedly be a useful reference source for general neurologists, neurology residents, and basic science fellow and students."
- Zbigniew K. Wszolek, Department of Neurology, Mayo Clinic Jacksonville in PARKINSONISM AND RELATED DISORDERS (September 2005)

"...this new textbook provides a comprehensive treatment of animal models used to study human movement disorders and should serve the neurologist, researcher, and other interested scientists very well."
--Dr. A.S. Fix, Central Product Safety, The Proctor and Gamble Co, Miami Valley Innovation Center, Cincinnati, OH, in VETERINARY PATHOLOGY (43:5) 2006