Movement Disorders

Movement Disorders

Genetics and Models

1st Edition - December 17, 2004

Write a review

  • Editors: Mark LeDoux, Mark LeDoux
  • eBook ISBN: 9780080470566

Purchase options

Purchase options
DRM-free (PDF, EPub, Mobi)
Sales tax will be calculated at check-out

Institutional Subscription

Free Global Shipping
No minimum order

Description

The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

Key Features

* Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to
* Includes contributions by expert movement disorder clinicians and top-level researchers in the field
* Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models

Readership

General neurologists, neurologists with subspecialty interest in movement disorders, neuroscientists, rehabilitation physicians, psychiatrists, and academic veterinarians with an interest in animal models.

Table of Contents


  • Table of Contents

    Preface

    List of Contributors

    Section A: Scientific Foundations

    A1: Classification and Clinical Features of Movement Disorders

    A2: Animal Models and the Science of Movement Disorders

    A3: Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders

    A4: Genetics of Spontaneous Mutations in Mice

    A5: Assessment of Movement Disorders in Rodents

    A6: Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals

    A7: Behavior in Drosophila: Analysis and Control

    A8: Use of C. elegans to Model Human Movement Disorders

    Section B: Parkinson Disease

    B1: The Phenotypic Spectrum of Parkinson Disease

    B2: MPTP-Induced Nigrostriatal Injury in Nonhuman Primates

    B3: From Man to Mouse: The MPTP Model of Parkinson Disease

    B4: Rotenone Rat and Other Neurotoxin Models of Parkinson Disease

    B5: Drosophila Models of Parkinson Disease

    B6: Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease

    B7: Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease

    B8: Motor Complications in Primate Models of Parkinson Disease

    B9: C. elegans Models of Parkinson Disease

    Section C: Dystonia

    C1: Clinical Features and Classification of the Human Dystonias

    C2: The Genetically Dystonic Rat

    C3: Animal Models of Benign Essential Blepharospasm and Hemifacial Spasm

    C4: Mouse Models of Dystonia

    C5: The Owl Monkey Model of Focal Dystonia

    C6: DYT1 Transgenic Mouse

    C7: The hph-1 Mouse

    Section D: Huntington Disease

    D1: Clinical and Pathological Characteristics of Huntington Disease

    D2: Transgenic Rodent Models of Huntington Disease

    D3: Knock-in and Knock-out Models of Huntington Disease

    D4: Drosophila Models of Huntington Disease

    Section E: Tremor Disorders

    E1: Neurophysiologic Characterization of Tremor

    E2: Essential Tremor

    E3: Harmaline Tremor

    E4: GABAA Receptor a1 Subunit Knockout Mice: A Novel Model of Essential Tremor

    E5: Production and Physiological Study of Holmes Tremor in Monkeys

    E6: The Campus Syndrome in Pietrain Pig

    Section F: Myoclonus

    F1: Pathophysiology, Neurophysiology, and Pharmacology of Human Myoclonus

    F2: Post-Hypoxic Myoclonus in Rodents

    F3: Baboon Model of Myoclonus

    Section G: Tic Disorders

    G1: Tourette Syndrome

    G2: Animal Models of Tourette Syndrome

    Section H: Paroxysmal Movement Disorders

    H1: Paroxysmal Dyskinesias in Humans

    H2: The Genetically Dystonic Hamster: An Animal Model of Paroxysmal Dystonia

    H3: Mouse Models of Hyperekplexia

    H4: Bovine Hyperekplexia

    H5: Movement Disorders in Drosophila Mutants of Potassium Channels and Biogenic Amine Pathways

    Section I: Progressive Supranuclear Palsy and Corticobasal Ganglionic Degeneration

    I1: Progressive Supranuclear Palsy and Corticobasal Degeneration

    I2: Genetic Susceptibility and Animal Modeling of PSP

    I3: Rodent Models of Tauopathies

    Section J: Multiple System Atrophy

    J1: Clinical Spectrum and Pathological Features of Multiple System Atrophy

    J2: Double-Lesion Animal Models of Multiple System Atrophy

    J3: A Mouse Model for Multiple System Atrophy

    Section K: Ataxias

    K1: Clinical and Pathological Features of Hereditary Ataxias

    K2: Acquired Ataxias

    K3: Animal Models of Spinocerebellar Ataxia Type 1 (SCA1)

    K4: Spinocerebellar Ataxia Type 2 (SCA2)

    K5: SCA7 Mouse Models

    K6: Animal Models of Friedreich Ataxia

    K7: Animal Oculomotor Data Illuminate Cerebellum-Related Eye Movement Disorders

    Section L: Spasticity

    L1: Spasticity

    L2: Hereditary Spastic Paraplegia: Clinical Features and Animal Models

    L3: The Spastic Rat with Sacral Spinal Cord Injury

    L4: Rat Spinal Cord Contusion Model of Spasticity

    Section M: Drug-induced Movement Disorders

    M1: Drug-Induced Movement Disorders

    M2: Neuroleptic-Induced Acute Dystonia and Tardive Dyskinesia in Primates

    M3: Motor Effects of Typical and Atypical Antipsychotic Drugs in Rodents

    M4: Animal Models of Drug-Induced Akathisia

    Section N: Restless legs Syndrome

    N1: Clinical Features and Animal Models of Restless Legs Syndrome and Periodic Limb Movement

    Index


Product details

  • No. of pages: 824
  • Language: English
  • Copyright: © Academic Press 2004
  • Published: December 17, 2004
  • Imprint: Academic Press
  • eBook ISBN: 9780080470566

About the Editors

Mark LeDoux

Mark S. LeDoux, MD, PhD is a physician-scientist at the University of Tennessee Health Science Center. At present he holds a joint appointment as Professor in the Departments of Neurology, and Anatomy and Neurobiology. He specializes in the neurological subspecialty of movement disorders and treats patients at the University of Tennessee Medical Group and Memphis VA hospital. As an active clinical researcher, Dr. LeDoux’s work has focused on the genetics and treatment of dystonia, Parkinson disease and Huntington disease. He has described Huntington disease in a nonagenarian and reported one of the world’s largest pedigrees with HDL2. In the laboratory, Dr. LeDoux has published extensively on the genetics and molecular biology of dystonia, mechanisms of cell death in Parkinson’s disease, animal models of dystonia and autism, and the neuroanatomy of motor systems. His work with the dt rat engendered paradigm shifts in dystonia and motor systems research. Dr. LeDoux’s lab showed that familial and sporadic adult-onset primary dystonia may be associated with rare sequence variants in THAP1 and CIZ1.

Affiliations and Expertise

Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA

Mark LeDoux

Mark S. LeDoux, MD, PhD is a physician-scientist at the University of Tennessee Health Science Center. At present he holds a joint appointment as Professor in the Departments of Neurology, and Anatomy and Neurobiology. He specializes in the neurological subspecialty of movement disorders and treats patients at the University of Tennessee Medical Group and Memphis VA hospital. As an active clinical researcher, Dr. LeDoux’s work has focused on the genetics and treatment of dystonia, Parkinson disease and Huntington disease. He has described Huntington disease in a nonagenarian and reported one of the world’s largest pedigrees with HDL2. In the laboratory, Dr. LeDoux has published extensively on the genetics and molecular biology of dystonia, mechanisms of cell death in Parkinson’s disease, animal models of dystonia and autism, and the neuroanatomy of motor systems. His work with the dt rat engendered paradigm shifts in dystonia and motor systems research. Dr. LeDoux’s lab showed that familial and sporadic adult-onset primary dystonia may be associated with rare sequence variants in THAP1 and CIZ1.

Affiliations and Expertise

Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA; Department of Anatomy & Neurobiology, University of Tennessee Health Science Center, Memphis, TN, USA

Ratings and Reviews

Write a review

There are currently no reviews for "Movement Disorders"