Movement Disorders

1st Edition

Genetics and Models

Print ISBN: 9780120883820
eBook ISBN: 9780080470566
Imprint: Academic Press
Published Date: 28th December 2004
Page Count: 824
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The use of animal models is a key aspect of scientific research in numerous fields of medicine. This book vigorously examines the important contributions and application of animal models to the understanding of human movement disorders and will serve as an essential resource for basic neuroscientists engaged in movement disorders research. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in different animal models to the clinical features, pathophysiology and treatment of human movement disorders. A vital feature of this book is an accompanying DVD with video clips of human movement disorders and their corresponding animal models. The book is divided into sections on Parkinson disease, Huntington disease, dystonia, tremor, paroxysmal movement disorders, ataxia, myoclonus, restless legs syndrome, drug-induced movement disorders, multiple system atrophy, progressive supranuclear palsy/corticobasal degeneration and spasticity. This book serves as an essential resource for both clinicians interested in the science being generated with animal models and basic scientists studying the pathogenesis of particular movement disorders.

Key Features

  • Provides a single comprehensive resource on animal models of movement disorders that academic clinicians, translational researchers, and basic neuroscientists can refer to
  • Includes contributions by expert movement disorder clinicians and top-level researchers in the field
  • Features a DVD containing over 170 video clips of human movement disorders and the corresponding animal models


General neurologists, neurologists with subspecialty interest in movement disorders, neuroscientists, rehabilitation physicians, psychiatrists, and academic veterinarians with an interest in animal models.

Table of Contents

Table of Contents Preface List of Contributors Section A: Scientific Foundations A1: Classification and Clinical Features of Movement Disorders A2: Animal Models and the Science of Movement Disorders A3: Generation of Transgenic and Gene-Targeted Mouse Models of Movement Disorders A4: Genetics of Spontaneous Mutations in Mice A5: Assessment of Movement Disorders in Rodents A6: Response Dynamics: Measurement of the Force and Rhythm of Motor Responses in Laboratory Animals A7: Behavior in Drosophila: Analysis and Control A8: Use of C. elegans to Model Human Movement Disorders Section B: Parkinson Disease B1: The Phenotypic Spectrum of Parkinson Disease B2: MPTP-Induced Nigrostriatal Injury in Nonhuman Primates B3: From Man to Mouse: The MPTP Model of Parkinson Disease B4: Rotenone Rat and Other Neurotoxin Models of Parkinson Disease B5: Drosophila Models of Parkinson Disease B6: Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease B7: Utility of 6-Hydroxydopamine Lesioned Rats in the Preclinical Screening of Novel Treatments for Parkinson Disease B8: Motor Complications in Primate Models of Parkinson Disease B9: C. elegans Models of Parkinson Disease Section C: Dystonia C1: Clinical Features and Classification of the Human Dystonias C2: The Genetically Dystonic Rat C3: Animal Models of Benign Essential Blepharospasm and Hemifacial Spasm C4: Mouse Models of Dystonia C5: The Owl Monkey Model of Focal Dystonia C6: DYT1 Transgenic Mouse C7: The hph-1 Mouse Section D: Huntington Disease D1: Clinical and Pathological Characteristics of Huntington Disease D2: Transgenic Rodent Models of Huntington Disease D3: Knock-in and Knock-out Models of Huntington Disease D4: Drosophila Models of Huntington Disease Section E: Tremor Disorders E1: Neurophysiolo


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Academic Press
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"The book is a timely review of animal models of movement disorders...The text is an excellent resource for neurologists and researchers specializing in movement disorders. In addition, this book will undoubtedly be a useful reference source for general neurologists, neurology residents, and basic science fellow and students." - Zbigniew K. Wszolek, Department of Neurology, Mayo Clinic Jacksonville in PARKINSONISM AND RELATED DISORDERS (September 2005) "...this new textbook provides a comprehensive treatment of animal models used to study human movement disorders and should serve the neurologist, researcher, and other interested scientists very well." --Dr. A.S. Fix, Central Product Safety, The Proctor and Gamble Co, Miami Valley Innovation Center, Cincinnati, OH, in VETERINARY PATHOLOGY (43:5) 2006