Mouse Models of Development and Disease

Mouse Models of Development and Disease

1st Edition - April 14, 2022

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  • Editors: Thomas Gridley, Leif Oxburgh
  • eBook ISBN: 9780128171325
  • Hardcover ISBN: 9780128171318

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Mouse Models of Development and Disease, Volume 148 in the Current Topics in Developmental Biology series, highlights new advances in the field, with this volume presenting chapters describing Mouse models of Charcot-Marie-Tooth disease, Mouse models in palate and craniofacial development, Uterine morphogenesis, Improving the translatability of mouse models of Alzheimer's disease, Mouse models for the study of clustered protocadherins, Mechanisms of organ regeneration in the spiny mouse, Comparative studies of organ vascularization, Modeling human urinary tract development and hereditary malformations, Innervation in organogenesis, Between embryo and adult: somatic growth of the kidney, and Mouse models in the study of Notch signaling.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Current Topics in Developmental Biology series
  • Updated release includes the latest information on Mouse Models of Development and Disease


Clinicians in the fields of clinical genetics and pediatrics; basic scientists in cell and developmental biology, anatomy, genetics and translational science; students and postdoctoral fellows who would like to enter these fields and make further discoveries.

Table of Contents

  • Cover image
  • Table of Contents
  • Title Page
  • Copyright
  • Contributors
  • Mouse models of development and disease: Preface
  • Origins of the field
  • Current work in the field
  • Chapter One: Mouse mutagenesis and phenotyping to generate models of development and disease
  • Abstract
  • 1: The mouse fancy and the early days of mouse genetics
  • 2: Mutagenesis in mice
  • 3: High throughput mutagenesis and phenotyping
  • 4: Looking forward
  • 5: Concluding remarks
  • Acknowledgments
  • References
  • Chapter Two: Mouse models in palate development and orofacial cleft research: Understanding the crucial role and regulation of epithelial integrity in facial and palate morphogenesis
  • Abstract
  • 1: Introduction
  • 2: Overview of midfacial morphogenesis and periderm differentiation
  • 3: Mouse genetic studies uncover a critical role for the embryonic periderm in orofacial morphogenesis
  • 4: Connections between epithelial integrity and epithelial–mesenchymal interactions regulating orofacial morphogenesis
  • 5: The roles of the periderm and the IRF6-p63 pathway in palatal fusion
  • 6: Concluding remarks
  • Acknowledgments
  • References
  • Chapter Three: Mammalian uterine morphogenesis and variations
  • Abstract
  • 1: Introduction
  • 2: Human uterine variation
  • 3: Human uterine variation syndromes
  • 4: Conclusion and final remarks
  • References
  • Chapter Four: Improving mouse models for the study of Alzheimer's disease
  • Abstract
  • 1: Introduction
  • 2: Overcoming limitations of existing mouse models relevant to early-onset AD
  • 3: Developing mouse models of late-onset AD (LOAD) through the MODEL-AD consortium
  • 4: Modeling vascular contributions
  • 5: Minimizing species differences to model inflammatory contributions to AD
  • 6: Mouse models at single-cell or cell-state resolution
  • 7: Integrating genetic context into mouse models to better represent the patient
  • 8: Training resources for use of animal models of Alzheimer's disease
  • 9: Conclusions
  • References
  • Chapter Five: Mouse models for the study of clustered protocadherins
  • Abstract
  • 1: Introduction
  • 2: Models to study isoform expression
  • 3: Models to study function
  • 4: Future directions
  • References
  • Chapter Six: Wound healing and regeneration in spiny mice (Acomys cahirinus)
  • Abstract
  • 1: Introduction
  • 2: Natural history and evolution of Acomys species
  • 3: Acomys and the evolution of mammalian wound healing
  • 4: Repair of skin wounds in Acomys
  • 5: Repair of skeletal muscle injury in Acomys
  • 6: Repair of kidney injury and regeneration of organ function in Acomys
  • 7: Repair of cardiac injury in Acomys
  • 8: Common features of Acomys regeneration studies
  • 9: Summary
  • Acknowledgments
  • References
  • Chapter Seven: Plumbing our organs: Lessons from vascular development to instruct lab generated tissues
  • Abstract
  • 1: Introduction
  • 2: Vascular development: Basic step-wise processes
  • 3: Vascularization of the kidney
  • 4: Organoid technology as a step toward organ replacement
  • 5: Organoids and vascularization
  • 6: The promise of vascular transcriptomes
  • 7: Vascularization of organoids increases epithelial maturity
  • 8: Methods for vascularization of organoids
  • 9: The challenges of organoid culture
  • 10: Perspectives for the future of vascularized engineered tissues
  • References
  • Chapter Eight: Innervation in organogenesis
  • Abstract
  • 1: Introduction
  • 2: Developmental origins of neurons
  • 3: Neurotrophins and axon guidance cues
  • 4: Organ innervation and developmental roles
  • 5: Discussion
  • References
  • Chapter Nine: Growth control of the kidney
  • Abstract
  • 1: Introduction
  • 2: Kidney anatomy
  • 3: Kidney development
  • 4: Cessation of nephrogenesis
  • 5: Nephron endowment
  • 6: Insulin like growth factors in prenatal growth control
  • 7: Growth hormone and insulin like growth factor in postnatal growth control
  • 8: Reactivation of kidney growth in the adult
  • 9: Perspectives
  • Acknowledgments
  • References

Product details

  • No. of pages: 282
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: April 14, 2022
  • Imprint: Academic Press
  • eBook ISBN: 9780128171325
  • Hardcover ISBN: 9780128171318

About the Serial Volume Editors

Thomas Gridley

Thomas Gridley is Associate Director, Center for Clinical & Translational Research, Faculty Scientist III, Maine Medical Center Research Institute, USA

Affiliations and Expertise

Associate Director, Maine Medical Center Research Institute, USA

Leif Oxburgh

Leif Oxburgh, Rogosin Institute in New York City, NY USA

Affiliations and Expertise

Rogosin Institute in New York City, NY USA

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