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Molecular Targets in Protein Misfolding and Neurodegenerative Disease - 1st Edition - ISBN: 9780128001868, 9780128004999

Molecular Targets in Protein Misfolding and Neurodegenerative Disease

1st Edition

Author: Pierfausto Seneci
eBook ISBN: 9780128004999
Hardcover ISBN: 9780128001868
Imprint: Academic Press
Published Date: 7th October 2014
Page Count: 314
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Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

Key Features

  • Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
  • Provides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
  • Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
  • Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
  • Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets


Graduate students in neuroscience, broader biological sciences, medicinal chemists, post-doctoral fellows, and drug discovery/ preclinical researchers

Table of Contents

Chapter 1: Protein Misfolding, Neurodegeneration and Tau

  • Abstract
  • 1.1. The neurodegeneration scenario
  • 1.2. Protein folding: physiological benefits and pathological consequences
  • 1.3. Tau: an intrinsically disordered, flexible, and aggregation-prone protein
  • 1.4. Tauopathies: aggregation-prone tau in neurodegenerative disease (NDD)

Chapter 2: Targeting the Protein Quality Control (PQC) Machinery

  • Abstract
  • 2.1. Molecular chaperones, PQC, and neurodegeneration
  • 2.2. Molecular targets
  • 2.3. Disease-modifying compounds

Chapter 3: Proteasomal Degradation of Soluble, Misfolded Proteins

  • Abstract
  • 3.1. UPS-mediated degradation of misfolded proteins
  • 3.2. UPS-mediated degradation of misfolded proteins in NDDs
  • 3.3. UPS—targets
  • 3.4. Disease-modifying compounds

Chapter 4: Unselective Disposal of Cellular Aggregates

  • Abstract
  • 4.1. Autophagy-mediated degradation of protein aggregates
  • 4.2. Autophagy-mediated degradation of protein aggregates in NDDs
  • 4.3. Macroautophagy—targets
  • 4.4. Disease-modifying compounds

Chapter 5: Selective Disposal of Insoluble Protein Aggregates

  • Abstract
  • 5.1. Aggrephagy-mediated degradation of protein aggregates
  • 5.2. Selective autophagy-mediated degradation of protein aggregates in NDDs
  • 5.3. Selective autophagy—targets
  • 5.4. Disease-modifying compounds

Chapter 6: Assembly and Disassembly of Protein Aggregates

  • Abstract
  • 6.1. Introduction
  • 6.2. Disordered protein aggregates and ordered amyloid fibrils
  • 6.3. Chaperone-driven disaggregation of protein aggregates
  • 6.4. Disease-modifying compounds


No. of pages:
© Academic Press 2014
7th October 2014
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Author

Pierfausto Seneci

Dr. Pierfausto Seneci is Associate Professor in the Department of Organic and Industrial Chemistry at the University of Milan. He is currently affiliated with the University of Milan Centre for Interdisciplinary Biomolecular Studies and Industrial Applications (CISI) Centre of Excellence, and is responsible for the Combinatorial Chemistry/High Throughput MedChem Laboratory. He has over 20 years of medicinal chemistry experience working in industry, and held business development positions with GSK, Sanofi, and start-up pharmaceutical companies including Sirenade and NiKem working in drug discovery, neurodegeneration, oncology, and antibacterials. He is author of approximately 80 papers on the topic and several book chapters, including the book “Solid-Phase Synthesis and Combinatorial Technologies” with Wiley-Interscience in 2000.

Affiliations and Expertise

Associate Professor, Department of Organic and Industrial Chemistry, University of Milan, Milan, Italy


" excellent biology-oriented discussion of the role of protein misfolding in neurodegenerative diseases...along with the forthcoming companion book, will provide neuroscientists with a strong foundation in this very important topic. Score: 88 - 3 Stars" --Doody's

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