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Molecular Neurology - 1st Edition - ISBN: 9780123695093, 9780080546186

Molecular Neurology

1st Edition

Author: Stephen Waxman
Hardcover ISBN: 9780123695093
eBook ISBN: 9780080546186
Imprint: Academic Press
Published Date: 17th July 2007
Page Count: 600
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Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.

Key Features

  • Describes the newest molecular aspects of neurological disorders
  • Provides an introduction to neurological disorders for basic scientists
  • Updates clinicians and clinical researchers on the most recent developments


Neuroscientists, molecular biologists, pharmacologists, neurologists, neurology residents, and clinical researchers.

Table of Contents

Molecular Neurology
Edited by Stephen G. Waxman
Table of Contents

PREFACE – Stephen G. Waxman

Chapter 1
Genetics as a Tool in Neurology
Dennis R. Johnson, Fuki M. Hisama

Chapter 2
Neurology and Genomic Medicine
Jeffery Vance

Chapter 3
Mitochondrial Function and Dysfunction in the Nervous System
Neggy Rismanchi and Craig Blackstone

Chapter 4
Neuronal Channels and Receptors
Alan L. Goldin

Chapter 5
Protein Misfolding, Chaperone Networks, and the Heat Shock Response
in the Nervous System
Cindy Voisine, Kai Orton, and Richard I. Morimoto

Chapter 6
Metabolic Biopsy of the Brain
Ognen A. C. Petroff

Chapter 7
Gene therapy approaches in neurology
Edward A. Burton, Joseph C. Glorioso, David J. Fink

Chapter 8
Programmed Cell Death and its Role in Neurological Disease
D. E. Bredesen, R. V. Rao and P. Mehlen1

Chapter 9
Developmental Neurology: A Molecular Perspective
Juan M. Pascual

Chapter 10
Metabolic Diseases of the Nervous System
Juan M. Pascual

Chapter 11
Genetic Disorders of Neuromuscular Development
Juan M. Pascual

Chapter 12
Molecular Mechanisms of Ischemic Brain Disease
Thomas M. Hemmen, Justin A. Zivin

Chapter 13
Hemorrhagic Brain Disease
Michael L. DiLuna, Kaya Bilguvar, Gamze Tanriover, Murat Gunel

Chapter 14
The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury
Noam Y. Harel, Yvonne S. Yang, Stephen M. Strittmatter, Jeffery D. Kocsis, and Stephen G. Waxman

Chapter 15
Parkinson’s Disease: Molecular Insights
Ted M. Dawson, Josesph M. Savitt, Valina L. Dawson

Chapter 16
The molecular basis of Alzheimer’s disease
Martin Ingelsson, Bradley T. Hyman

Chapter 17
Polyglutamine Disorders including Huntington’s Disease
Sokol V. Todi, Aislinn J. Williams, Henry L. Paulson

Chapter 18
Friedreich’s Ataxia and Related RNA Loss-Of-Function Disorders
Masimo Pandolfo

Chapter 19
DYT1, a Primary Torsion Dystonia
Susan B. Bressman, Laurie Ozelius

Chapter 20
Motor Neuron Disease: Amyotrophic Lateral Sclerosis
Nicholas J. Maragakis and Jeffrey D. Rothstein

Chapter 21
Genetic Disorders of the Autonomic Nervous System
Stephen J. Peroutka

Chapter 22
Multiple sclerosis as a neurodegenerative disease
Stephen G. Waxman

Chapter 23
Acquired Epilepsy: Cellular and Molecular Mechanisms
Christopher B. Ransom and Hal Blumenfeld

Chapter 24
Disorders of Excitation and Transmission: Genetic Epilepsies
Ingo Helbig, Ingrid E. Scheffer and Samuel F. Berkovic

Chapter 25
Hyperekplexia (startle disease / stiff baby syndrome): Molecular pathology of the glycine receptor complex
Cord-Michael Becker

Chapter 26
Tourette’s Syndrome
James F. Leckman, Michael H. Bloch

Chapter 27
Disorders of Sleep and Circadian Rhythms
Sebastiaan Overeem, Gert Jan Lammers, Mehdi Tafti

Chapter 28
Chronic pain as a molecular disorder
John N Wood and Stephen G Waxman

Chapter 29
Migraine as a cerebral ionopathy with impaired central sensory processing
Michel D Ferrari, Arn M.J.M. van den Maagdenberg, Rune R. Frants, and Peter J. Goadsby

Chapter 30
Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies
John A. Kamholz
Chapter 31
Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis
Alexander Flugel, Hartmut Wekerle

Chapter 32
Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal
Angela Vincent

Chapter 33
Paraneoplastic Neurologic Syndromes
Josep Dalmau

Chapter 34
Mitochondrial Disorders
Salvator DiMauro, Eric A. Schon

Chapter 35
Molecular Neurology of HIV-1 Infection and AIDs
Markus Kaul, Stuart A. Lipton


No. of pages:
© Academic Press 2007
17th July 2007
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Author

Stephen Waxman

Affiliations and Expertise

Yale University School of Medicine, CT, USA

Ratings and Reviews