Molecular Neurology

Molecular Neurology

1st Edition - July 17, 2007

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  • Author: Stephen Waxman
  • Hardcover ISBN: 9780123695093
  • eBook ISBN: 9780080546186

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Description

Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. Molecular Neurology highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.

Key Features

  • Describes the newest molecular aspects of neurological disorders
  • Provides an introduction to neurological disorders for basic scientists
  • Updates clinicians and clinical researchers on the most recent developments

Readership

Neuroscientists, molecular biologists, pharmacologists, neurologists, neurology residents, and clinical researchers.

Table of Contents

  • Molecular Neurology
    Edited by Stephen G. Waxman
    Table of Contents


    PREFACE – Stephen G. Waxman

    Chapter 1
    Genetics as a Tool in Neurology
    Dennis R. Johnson, Fuki M. Hisama

    Chapter 2
    Neurology and Genomic Medicine
    Jeffery Vance

    Chapter 3
    Mitochondrial Function and Dysfunction in the Nervous System
    Neggy Rismanchi and Craig Blackstone

    Chapter 4
    Neuronal Channels and Receptors
    Alan L. Goldin

    Chapter 5
    Protein Misfolding, Chaperone Networks, and the Heat Shock Response
    in the Nervous System
    Cindy Voisine, Kai Orton, and Richard I. Morimoto

    Chapter 6
    Metabolic Biopsy of the Brain
    Ognen A. C. Petroff

    Chapter 7
    Gene therapy approaches in neurology
    Edward A. Burton, Joseph C. Glorioso, David J. Fink

    Chapter 8
    Programmed Cell Death and its Role in Neurological Disease
    D. E. Bredesen, R. V. Rao and P. Mehlen1

    Chapter 9
    Developmental Neurology: A Molecular Perspective
    Juan M. Pascual

    Chapter 10
    Metabolic Diseases of the Nervous System
    Juan M. Pascual

    Chapter 11
    Genetic Disorders of Neuromuscular Development
    Juan M. Pascual

    Chapter 12
    Molecular Mechanisms of Ischemic Brain Disease
    Thomas M. Hemmen, Justin A. Zivin

    Chapter 13
    Hemorrhagic Brain Disease
    Michael L. DiLuna, Kaya Bilguvar, Gamze Tanriover, Murat Gunel

    Chapter 14
    The Dawn of Molecular and Cellular Therapies for Traumatic Spinal Cord Injury
    Noam Y. Harel, Yvonne S. Yang, Stephen M. Strittmatter, Jeffery D. Kocsis, and Stephen G. Waxman

    Chapter 15
    Parkinson’s Disease: Molecular Insights
    Ted M. Dawson, Josesph M. Savitt, Valina L. Dawson

    Chapter 16
    The molecular basis of Alzheimer’s disease
    Martin Ingelsson, Bradley T. Hyman

    Chapter 17
    Polyglutamine Disorders including Huntington’s Disease
    Sokol V. Todi, Aislinn J. Williams, Henry L. Paulson

    Chapter 18
    Friedreich’s Ataxia and Related RNA Loss-Of-Function Disorders
    Masimo Pandolfo

    Chapter 19
    DYT1, a Primary Torsion Dystonia
    Susan B. Bressman, Laurie Ozelius

    Chapter 20
    Motor Neuron Disease: Amyotrophic Lateral Sclerosis
    Nicholas J. Maragakis and Jeffrey D. Rothstein

    Chapter 21
    Genetic Disorders of the Autonomic Nervous System
    Stephen J. Peroutka

    Chapter 22
    Multiple sclerosis as a neurodegenerative disease
    Stephen G. Waxman

    Chapter 23
    Acquired Epilepsy: Cellular and Molecular Mechanisms
    Christopher B. Ransom and Hal Blumenfeld

    Chapter 24
    Disorders of Excitation and Transmission: Genetic Epilepsies
    Ingo Helbig, Ingrid E. Scheffer and Samuel F. Berkovic

    Chapter 25
    Hyperekplexia (startle disease / stiff baby syndrome): Molecular pathology of the glycine receptor complex
    Cord-Michael Becker

    Chapter 26
    Tourette’s Syndrome
    James F. Leckman, Michael H. Bloch

    Chapter 27
    Disorders of Sleep and Circadian Rhythms
    Sebastiaan Overeem, Gert Jan Lammers, Mehdi Tafti

    Chapter 28
    Chronic pain as a molecular disorder
    John N Wood and Stephen G Waxman

    Chapter 29
    Migraine as a cerebral ionopathy with impaired central sensory processing
    Michel D Ferrari, Arn M.J.M. van den Maagdenberg, Rune R. Frants, and Peter J. Goadsby

    Chapter 30
    Dysmyelinating and Demyelinating Disorders of the PNS, or Inherited Neuropathies
    John A. Kamholz
    Chapter 31
    Demyelinating Diseases: Immunological Mechanisms in the Pathogenesis of Multiple Sclerosis
    Alexander Flugel, Hartmut Wekerle

    Chapter 32
    Molecular Neurology: Autoimmune disorders of the neuromuscular junction and motor nerve terminal
    Angela Vincent

    Chapter 33
    Paraneoplastic Neurologic Syndromes
    Josep Dalmau

    Chapter 34
    Mitochondrial Disorders
    Salvator DiMauro, Eric A. Schon

    Chapter 35
    Molecular Neurology of HIV-1 Infection and AIDs
    Markus Kaul, Stuart A. Lipton

Product details

  • No. of pages: 600
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: July 17, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123695093
  • eBook ISBN: 9780080546186

About the Author

Stephen Waxman

Affiliations and Expertise

Yale University School of Medicine, CT, USA

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