Why a book on molecular neurology? Molecular neuroscience is advancing at a spectacular rate. As it does so, it is revealing important clues to the pathogenesis and pathophysiology of neurological diseases, and to the therapeutic targets that they present. Medicines work by targeting molecules. The more specific the targeting, the more specific the actions, and the fewer the side effects. This book highlights, for graduate and MD-PhD students, research fellows and research-oriented clinical fellows, and researchers in the neurosciences and other biomedical sciences, the principles underlying molecular medicine as related to neurology. Written by internationally recognized experts, this well-illustrated and well-referenced book presents the most up-to-date principles and disease examples relevant to molecular neurology, and reviews the concepts, strategies, and latest progress in this field. This book will interest anyone studying the molecular basis of neurology, or developing new therapies in neurology.

Key Features

* Describes the newest molecular aspects of neurological disorders * Provides an introduction to neurological disorders for basic scientists * Updates clinicians and clinical researchers on the most recent developments


Neuroscientists, molecular biologists, pharmacologists, neurologists, neurology residents, and clinical researchers.

Table of Contents

Molecular Neurology Edited by Stephen G. Waxman Table of Contents PREFACE – Stephen G. Waxman Chapter 1 Genetics as a Tool in Neurology Dennis R. Johnson, Fuki M. Hisama Chapter 2 Neurology and Genomic Medicine Jeffery Vance Chapter 3 Mitochondrial Function and Dysfunction in the Nervous System Neggy Rismanchi and Craig Blackstone Chapter 4 Neuronal Channels and Receptors Alan L. Goldin Chapter 5 Protein Misfolding, Chaperone Networks, and the Heat Shock Response in the Nervous System Cindy Voisine, Kai Orton, and Richard I. Morimoto Chapter 6 Metabolic Biopsy of the Brain Ognen A. C. Petroff Chapter 7 Gene therapy approaches in neurology Edward A. Burton, Joseph C. Glorioso, David J. Fink Chapter 8 Programmed Cell Death and its Role in Neurological Disease D. E. Bredesen, R. V. Rao and P. Mehlen1 Chapter 9 Developmental Neurology: A Molecular Perspective Juan M. Pascual Chapter 10 Metabolic Diseases of the Nervous System Juan M. Pascual Chapter 11 Genetic Disorders of Neuromuscular Development Juan M. Pascual Chapter 12 Molecular Mechanisms of Ischemic Brain Disease Thomas M. Hemmen, Justin A. Zivin Chapter 13 Hemorrhagic Brain Disease Michael L. DiLuna, Kaya Bilguvar, Gamze Tanriover, Murat Gunel


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© 2007
Academic Press
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About the author

Stephen Waxman

Affiliations and Expertise

Yale University School of Medicine, CT, USA