Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia

Biomarkers, Neurochemistry, and Therapy

1st Edition - April 15, 2019
This is the Latest Edition
  • Author: Akhlaq A. Farooqui
  • eBook ISBN: 9780128167311
  • Paperback ISBN: 9780128163474

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Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. 

Key Features

  • Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia
  • Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia
  • Discusses the synthesis, metabolism, and role of lipid mediators in dementia


Researchers, physicians, students in neuroscience, neurology, neurochemistry and neuropharmacology

Table of Contents

  • 1. Neurochemical Aspects of Dementia
    2. Neurochemical aspects of post-stroke dementia
    3. Neurochemical Aspects of Alzheimer’s Type of Dementia
    4. Neurochemical aspects of Lewy body dementia
    5. Neurochemical aspects of vascular dementia
    6. Neurochemical aspects of frontotemporal dementia
    7. Potential treatment strategies for dementia with pharmacological and non-pharmacological interventions
    8. Potential treatment strategies for the treatment of dementia with Chinese medicinal plants
    9. Potential treatment strategies of dementia with Ayurvedic medicines
    10. Summary and perspective for future research on dementia

Product details

  • No. of pages: 386
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: April 15, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128167311
  • Paperback ISBN: 9780128163474

About the Author

Akhlaq A. Farooqui

Akhlaq A. Farooqui
Akhlaq A. Farooqui is a leader in the field of signal transduction processes, lipid mediators, phospholipases, glutamate neurotoxicity, and neurological disorders. He is a research scientist in the Department of Molecular and Cellular Biochemistry at The Ohio State University. He has published cutting edge research on the role of phospholipases A2 in signal transduction processes, generation and identification of lipid mediators during neurodegeneration by lipidomics. He has studied the involvement of glycerophospholipid, sphingolipid-, and cholesterol-derived lipid mediators in kainic acid neurotoxicity, an experimental model of neurodegenerative diseases. Akhlaq A. Farooqui has discovered the stimulation of plasmalogen- selective phospholipase A2 in brains of patients with Alzheimer disease (AD). Stimulation of this enzyme may not only be responsible for the deficiency of plasmalogens in neural membranes of AD patients, but also be related to the loss of synapse in the AD.

Affiliations and Expertise

Research Scientist, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, OH, USA