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Molecular Genetic Medicine - 1st Edition - ISBN: 9780124620032, 9781483276052

Molecular Genetic Medicine

1st Edition

Volume 3

Editor: Theodore Friedmann
eBook ISBN: 9781483276052
Imprint: Academic Press
Published Date: 30th August 1993
Page Count: 198
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Molecular Genetic Medicine, Volume III, summarizes progress in several of the most important areas of modern molecular genetics and medicine. The book opens with a chapter on the birth and early development of the field of human gene therapy and the earliest conceptual and technical descriptions of the issues and opportunities in this new area of medicine. This is followed by separate chapters on the gene responsible for cystic fibrosis; interactions and genetic phenomena that accompany the progression of astrocytic tumors; and molecular biology of Alzheimer’s disease; and the search for the Huntington's disease gene and the role of genetic instability in this disease. The final chapter discusses the ways in which both the medical insurance and genetics industries will have to respond to changes in the power of genetic information and its ability to predict coronary vascular disease, cancer, neurological disease, and all the other common afflictions that constitute the bulk of their businesses.

Table of Contents



1 Milestones and Events in the Early Development of Human Gene Therapy

I. Phase 1. Prior to 1970: Genetically Marked Cells and DNA-Mediated Transformation

II. Phase 2. The Cline Experiment, Efficient Vectors, In Vitro Models, and the Maturing Ethical and Public Policy Debate

III. Phase 3. The Regulatory Process and the First Direct Clinical Applications: The Recombinant Advisory Committee (RAC), Its Gene Therapy Subcommittee, and the Food and Drug Administration (FDA)


2 Molecular Biology of Cystic Fibrosis

I. Introduction and History

II. Identification of the CF Gene

III. Mechanism of CFTR Function

IV. Genotype/Phenotype Relationships

V. Carrier Screening

VI. Therapeutic Prospects

VII. Summary


3 Genetics of Astrocytic Tumor Progression

I. Cancer is a Genetic Disease

II. Multistep Carcinogenesis

III. Tumor Progression

IV. Phenotypes of the Malignant Process

V. Mechanisms in Tumor Progression

VI. Clinical-Pathologic Correlation

VII. Biology of Astrocytic Tumors

VIII. Genetics of Astrocytic Tumors

IX. A Clonal Evolution Model for Astrocytic Tumors

X. Testing the Genetic Model

XI. Conclusion


4 Molecular Biology of Alzheimer's Disease

I. Introduction

II. History

III. Epidemiology

IV. Genetics

V. Clinical and Neuropsychological Features

VI. Diagnosis

VII. Treatment

VIII. Nerve Growth Factor and Related Molecules in the Central Nervous System

IX. Central Actions of Nerve Growth Factor

X. NGF-Related Trophic Factors: The Neurotrophins

XI. Neurotrophin Receptors

XII. NGF Mechanism of Action

XIII. A Model of Trophic Factor Action in Neurodegenerative Disease

XIV. Molecular Neuropathology

XV. Amyloid Deposition in Alzheimer's Disease

XVI. βΑΡΡ Processing

XVII. Conclusion: Clinical and Societal Implications


5 Hunting for Huntington's Disease

I. Introduction

II. Finding a Landmark near HD

III. Which Way to the Prey?

IV. Physical Layout of the Search Area

V. Tools for Tracking

VI. Limiting the Hunt Using Crossovers in Disease Pedigrees

VII. The Historical Trail of HD in Allele Associations

VIII. What is the Nature of the Quarry?


Note Added in Proof: Hunting's Done!

6 Genetics, Insurance, and the Ethics of Genetic Counseling

I. Introduction: Genetic Prediction and the Challenge to Insurance

II. Health Insurance

III. Life Insurance

IV. Ethical Conflicts of Providers of Genetic Services

V. Conclusion




No. of pages:
© Academic Press 1993
30th August 1993
Academic Press
eBook ISBN:

About the Editor

Theodore Friedmann

School of Medicine, University of California at San Diego, USA

Affiliations and Expertise

School of Medicine, University of California at San Diego, USA

Ratings and Reviews