Molecular Genetic Medicine

Molecular Genetic Medicine

Volume 3

1st Edition - August 30, 1993

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  • Editor: Theodore Friedmann
  • eBook ISBN: 9781483276052

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Molecular Genetic Medicine, Volume III, summarizes progress in several of the most important areas of modern molecular genetics and medicine. The book opens with a chapter on the birth and early development of the field of human gene therapy and the earliest conceptual and technical descriptions of the issues and opportunities in this new area of medicine. This is followed by separate chapters on the gene responsible for cystic fibrosis; interactions and genetic phenomena that accompany the progression of astrocytic tumors; and molecular biology of Alzheimer’s disease; and the search for the Huntington's disease gene and the role of genetic instability in this disease. The final chapter discusses the ways in which both the medical insurance and genetics industries will have to respond to changes in the power of genetic information and its ability to predict coronary vascular disease, cancer, neurological disease, and all the other common afflictions that constitute the bulk of their businesses.

Table of Contents

  • Contributors


    1 Milestones and Events in the Early Development of Human Gene Therapy

    I. Phase 1. Prior to 1970: Genetically Marked Cells and DNA-Mediated Transformation

    II. Phase 2. The Cline Experiment, Efficient Vectors, In Vitro Models, and the Maturing Ethical and Public Policy Debate

    III. Phase 3. The Regulatory Process and the First Direct Clinical Applications: The Recombinant Advisory Committee (RAC), Its Gene Therapy Subcommittee, and the Food and Drug Administration (FDA)


    2 Molecular Biology of Cystic Fibrosis

    I. Introduction and History

    II. Identification of the CF Gene

    III. Mechanism of CFTR Function

    IV. Genotype/Phenotype Relationships

    V. Carrier Screening

    VI. Therapeutic Prospects

    VII. Summary


    3 Genetics of Astrocytic Tumor Progression

    I. Cancer is a Genetic Disease

    II. Multistep Carcinogenesis

    III. Tumor Progression

    IV. Phenotypes of the Malignant Process

    V. Mechanisms in Tumor Progression

    VI. Clinical-Pathologic Correlation

    VII. Biology of Astrocytic Tumors

    VIII. Genetics of Astrocytic Tumors

    IX. A Clonal Evolution Model for Astrocytic Tumors

    X. Testing the Genetic Model

    XI. Conclusion


    4 Molecular Biology of Alzheimer's Disease

    I. Introduction

    II. History

    III. Epidemiology

    IV. Genetics

    V. Clinical and Neuropsychological Features

    VI. Diagnosis

    VII. Treatment

    VIII. Nerve Growth Factor and Related Molecules in the Central Nervous System

    IX. Central Actions of Nerve Growth Factor

    X. NGF-Related Trophic Factors: The Neurotrophins

    XI. Neurotrophin Receptors

    XII. NGF Mechanism of Action

    XIII. A Model of Trophic Factor Action in Neurodegenerative Disease

    XIV. Molecular Neuropathology

    XV. Amyloid Deposition in Alzheimer's Disease

    XVI. βΑΡΡ Processing

    XVII. Conclusion: Clinical and Societal Implications


    5 Hunting for Huntington's Disease

    I. Introduction

    II. Finding a Landmark near HD

    III. Which Way to the Prey?

    IV. Physical Layout of the Search Area

    V. Tools for Tracking

    VI. Limiting the Hunt Using Crossovers in Disease Pedigrees

    VII. The Historical Trail of HD in Allele Associations

    VIII. What is the Nature of the Quarry?


    Note Added in Proof: Hunting's Done!

    6 Genetics, Insurance, and the Ethics of Genetic Counseling

    I. Introduction: Genetic Prediction and the Challenge to Insurance

    II. Health Insurance

    III. Life Insurance

    IV. Ethical Conflicts of Providers of Genetic Services

    V. Conclusion



Product details

  • No. of pages: 198
  • Language: English
  • Copyright: © Academic Press 1993
  • Published: August 30, 1993
  • Imprint: Academic Press
  • eBook ISBN: 9781483276052

About the Editor

Theodore Friedmann

School of Medicine, University of California at San Diego, USA

Affiliations and Expertise

School of Medicine, University of California at San Diego, USA

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