Molecular Endocrinology - 1st Edition - ISBN: 9780121112301, 9780323155762

Molecular Endocrinology

1st Edition

Authors: Franklyn Bolander
eBook ISBN: 9780323155762
Imprint: Academic Press
Published Date: 28th April 1989
Page Count: 328
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Description

Molecular Endocrinology examines basic principles in molecular endocrinology using selected examples. It looks at the molecular aspects of hormone action, from hormone-receptor interactions to second messenger generation, gene induction, and post-transcriptional control. It also explores the regulation of nuclear receptors and membrane receptors, the nontranscriptional effects of hormones, the modifications of histone and nonhistone protein, the molecular evolution of the endocrine system, and the molecular bases of endocrinopathies. Organized into five sections comprised of 16 chapters, this book begins with a brief summary of general endocrinology and then discusses the basic characteristics of hormones and their regulation, illustrated by the hormonal control of calcium metabolism. It explains other major endocrine systems, including the hypothalamus, pituitary gland, and thyroid gland. The remainder of the text focuses on receptors and how to determine their number and affinity; the structure, function, and metabolism of nuclear and membrane receptors; the mechanisms for the regulation of receptor activity; the major second messengers, such as cyclic nucleotides, and how they can directly affect cellular processes; the role of phospholipids in signal transduction; mediators such as polyamines, oligosaccharides, and the cytoskeleton; the mechanisms by which hormones and their second messengers affect gene expression; and the hormonal control of various post-transcriptional events. This book will be of interest to biologists and those working in the field of molecular endocrinology.

Table of Contents


Preface

Part 1 Introduction and General Endocrinology

Chapter 1 Introduction

Chapter 2 General Endocrinology

Part 2 Receptors

Chapter 3 Kinetics

Chapter 4 Nuclear Receptors

Chapter 5 Membrane Receptors

Chapter 6 Receptor Regulation

Part 3 Transduction

Chapter 7 Cyclic Nucleotides

Chapter 8 Calcium, Calmodulin, and Phospholipids

Chapter 9 Miscellaneous Second Messengers

Chapter 10 Nontranscriptional Effects of Hormones

Part 4 Gene Regulation by Hormones

Chapter 11 Transcriptional Regulation

Chapter 12 Histone and Nonhistone Protein Modifications

Chapter 13 Posttranscriptional Control

Part 5 Special Topics

Chapter 14 Molecular Evolution of the Endocrine System

Chapter 15 Hormones and Oncogenes

Chapter 16 Molecular Bases of Endocrinopathies

List of Abbreviations

Index






Details

No. of pages:
328
Language:
English
Copyright:
© Academic Press 1989
Published:
Imprint:
Academic Press
eBook ISBN:
9780323155762

About the Author

Franklyn Bolander