Molecular Endocrinology

Molecular Endocrinology

1st Edition - April 28, 1989

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  • Author: Franklyn Bolander
  • eBook ISBN: 9780323155762

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Molecular Endocrinology examines basic principles in molecular endocrinology using selected examples. It looks at the molecular aspects of hormone action, from hormone-receptor interactions to second messenger generation, gene induction, and post-transcriptional control. It also explores the regulation of nuclear receptors and membrane receptors, the nontranscriptional effects of hormones, the modifications of histone and nonhistone protein, the molecular evolution of the endocrine system, and the molecular bases of endocrinopathies. Organized into five sections comprised of 16 chapters, this book begins with a brief summary of general endocrinology and then discusses the basic characteristics of hormones and their regulation, illustrated by the hormonal control of calcium metabolism. It explains other major endocrine systems, including the hypothalamus, pituitary gland, and thyroid gland. The remainder of the text focuses on receptors and how to determine their number and affinity; the structure, function, and metabolism of nuclear and membrane receptors; the mechanisms for the regulation of receptor activity; the major second messengers, such as cyclic nucleotides, and how they can directly affect cellular processes; the role of phospholipids in signal transduction; mediators such as polyamines, oligosaccharides, and the cytoskeleton; the mechanisms by which hormones and their second messengers affect gene expression; and the hormonal control of various post-transcriptional events. This book will be of interest to biologists and those working in the field of molecular endocrinology.

Table of Contents

  • Preface

    Part 1 Introduction and General Endocrinology

    Chapter 1 Introduction

    Chapter 2 General Endocrinology

    Part 2 Receptors

    Chapter 3 Kinetics

    Chapter 4 Nuclear Receptors

    Chapter 5 Membrane Receptors

    Chapter 6 Receptor Regulation

    Part 3 Transduction

    Chapter 7 Cyclic Nucleotides

    Chapter 8 Calcium, Calmodulin, and Phospholipids

    Chapter 9 Miscellaneous Second Messengers

    Chapter 10 Nontranscriptional Effects of Hormones

    Part 4 Gene Regulation by Hormones

    Chapter 11 Transcriptional Regulation

    Chapter 12 Histone and Nonhistone Protein Modifications

    Chapter 13 Posttranscriptional Control

    Part 5 Special Topics

    Chapter 14 Molecular Evolution of the Endocrine System

    Chapter 15 Hormones and Oncogenes

    Chapter 16 Molecular Bases of Endocrinopathies

    List of Abbreviations


Product details

  • No. of pages: 328
  • Language: English
  • Copyright: © Academic Press 1989
  • Published: April 28, 1989
  • Imprint: Academic Press
  • eBook ISBN: 9780323155762

About the Author

Franklyn Bolander

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