Volume 24. Molecular Diversity and Combinatorial Chemistry

1st Edition

Principles and Applications


  • Michael Pirrung
  • Molecular Diversity and Combinatorial Chemistry

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    The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact. Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field. The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic. This volume has been written with the advanced undergraduate and graduate student in mind.

    Key Features

    * Making the main concepts of the field of molecular diversity and combinatorial chemistry accessible to non-specialists * written specifically for the advanced undergraduate student or graduate student * This book is an excellent guide to the conceptual framework of the field.


    For undergraduate and post gradate students, instructors and lecturers in the field of combinatorial chemistry.

    Table of Contents

    Nature: The Original Combinatorial Chemist Biopolymers constitute natural libraries
    Selection and evolution
    The expression of genetic information
    Combinatorial assembly of antibody genes
    Molecular solutions to combinatorial problems Synthetic Peptide Libraries Solid-phase peptide synthesis
    Peptides on pins
    Other iterative deconvolution strategies
    Examples of split/couple/mix peptide libraries
    Positional scanning
    Epilogue Supports, Linkers, and Reagents for Peptide Synthesis Polystyrenes
    PEG-grafted supports
    Coupling strategies Supports and Linkers for Small Molecule Synthesis New resins and linkers
    Ring-forming cleavage
    Loading Encoded Combinatorial Chemistry Directed Sorting Unnatural Oligomers for Library Synthesis Peptoids
    Peptidyl phosphonates
    Oligoureas Analytical Methods for Solid-phase Synthesis Product identification
    Gel-phase NMR
    High-resolution magic angle spinning NMR
    On-bead infrared spectroscopy
    Mass spectrometry
    Non-spectroscopic methods Supported Solution-phase Synthesis Polyethylene glycols
    Fluorous synthesis Solution-phase Parallel Synthesis Scavenging resins
    Ion-exchange resins


    No. of pages:
    © 2004
    Elsevier Science
    Print ISBN:
    Electronic ISBN:

    About the editor

    Michael Pirrung

    Michael Pirrung, Ph.D., was trained as a synthetic organic chemist at UT-Austin, UC-Berkeley, and Columbia University with eminent synthetic chemists Clayton Heathcock and Gilbert Stork. His independent career began in the 1980s at Stanford University and the biotech start-up company Affymax. In 1990, he joined Duke University where he founded and directed the Program in Biological Chemistry. In 2004, he joined the UC-Riverside Chemistry department as UC Presidential Chair, and in 2012 became Distinguished Professor. He has been a visiting professor at UC-Berkeley, Baylor College of Medicine, Oxford, UC-San Diego, UC-Irvine, and Caltech. He has trained over 100 graduate students and postdoctoral fellows. He has held Hertz, Sloan, and Guggenheim fellowships and a NSF Presidential Young Investigator Award. He has over 170 peer-reviewed publications, more than 40 US and international patents, and has authored six books. The scope of his research has been broad, including natural product total synthesis, photochemical methods development, mechanistic enzymology, rhodium carbenoid chemistry, microarrays, combinatorial chemistry, and medicinal chemistry. His current work emphasizes peptide chemistry. His microarray work has been particularly recognized, with the 1991 AAAS-Newcomb Cleveland Prize, the 1993 Intellectual Property Owners Distinguished Inventor Award, the 2004 Chemical Pioneer Award of the American Institute of Chemists, and the 2006 European Inventor of the Year (for small and medium-sized enterprises). His editorial board service includes Cell Chemical Biology and Journal of Combinatorial Chemistry. He has worked extensively with development-stage and Fortune 500 companies as a consultant or scientific advisory board member. He also has an active practice as an expert witness for litigation in nucleic acid diagnostics and generic drugs.

    Affiliations and Expertise

    University of California, Riverside, USA


    @qu: "This book is ideal for an advanced student or any chemist who, not being directly involved in combinatorial chemistry, wishes to get a general idea about its principles and applications. In particular, I recommend this book to all academic teachers that give a course (at master or Ph.D. level) on combinatorial chemistry and to their students. I will certainly use it myself as a guidance for my own course on the subject." @source: Prof. Luca Banfi, University of Genova, MOLECULAR DIVERSITY, 2005