Molecular Diversity and Combinatorial Chemistry - 1st Edition - ISBN: 9780080445328, 9780080913933

Molecular Diversity and Combinatorial Chemistry, Volume 24

1st Edition

Principles and Applications

Print ISBN: 9780080445328
eBook ISBN: 9780080913933
Imprint: Elsevier Science
Published Date: 17th September 2004
Page Count: 188

Institutional Access


The field of combinatorial chemistry has seen tremendous growth over the past decade, with a prominence that suggests it will have a continuing impact.

Volume 24 in the Tetrahedron Organic Chemistry Series represents new approaches to solving problems in chemical reactivity and function. It emphasises principles and exemplifies these with examples drawn from recent literature and thus is an excellent guide to the conceptual framework of the field.

The textbook includes exercises and worked problems which can provide more independent learning experiences and can also be used by an instructor leading a class on this topic. This volume has been written with the advanced undergraduate and graduate student in mind.

Key Features

  • Making the main concepts of the field of molecular diversity and combinatorial chemistry accessible to non-specialists
  • written specifically for the advanced undergraduate student or graduate student
  • This book is an excellent guide to the conceptual framework of the field.


For undergraduate and post gradate students, instructors and lecturers in the field of combinatorial chemistry.

Table of Contents

Nature: The Original Combinatorial Chemist Biopolymers constitute natural libraries

Selection and evolution
The expression of genetic information
Combinatorial assembly of antibody genes
Molecular solutions to combinatorial problems

Synthetic Peptide Libraries Solid-phase peptide synthesis
Peptides on pins
Other iterative deconvolution strategies
Examples of split/couple/mix peptide libraries
Positional scanning

Supports, Linkers, and Reagents for Peptide Synthesis Polystyrenes
PEG-grafted supports
Coupling strategies

Supports and Linkers for Small Molecule Synthesis New resins and linkers
Ring-forming cleavage

Encoded Combinatorial Chemistry

Directed Sorting

Unnatural Oligomers for Library Synthesis Peptoids
Peptidyl phosphonates

Analytical Methods for Solid-phase Synthesis Product identification
Gel-phase NMR
High-resolution magic angle spinning NMR
On-bead infrared spectroscopy
Mass spectrometry
Non-spectroscopic methods

Supported Solution-phase Synthesis Polyethylene glycols
Fluorous synthesis

Solution-phase Parallel Synthesis Scavenging resins
Ion-exchange resins
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© Elsevier Science 2004
Elsevier Science
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@qu: "This book is ideal for an advanced student or any chemist who, not being directly involved in combinatorial chemistry, wishes to get a general idea about its principles and applications. In particular, I recommend this book to all academic teachers that give a course (at master or Ph.D. level) on combinatorial chemistry and to their students. I will certainly use it myself as a guidance for my own course on the subject." @source: Prof. Luca Banfi, University of Genova, MOLECULAR DIVERSITY, 2005