Molecular Basis of Olfaction

Molecular Basis of Olfaction

1st Edition - January 21, 2015

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  • Editor: Richard Glatz
  • eBook ISBN: 9780128029138
  • Hardcover ISBN: 9780128029121

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The scope of this volume of Progress in Molecular Biology and Translational Science includes the molecular regulation of olfactory processes in vertebrates and insects including detailed discussion of olfactory proteins, signaling cascades and olfactory receptor modeling. In addition, because insect olfaction is an important and emerging field, it is also discussed in the context of key research questions such as disruption of host-finding by insect disease vectors, elucidation of the diverse range of compounds that are detected by insects, and the detection of pheromones by moths.

Key Features

  • Comprehensive coverage of molecular processes in olfaction of vertebrates and insects
  • Focus on the emerging field of insect olfaction
  • Contributions by leading research groups in their fields, from a range of countries
  • Discusses fundamental knowledge and also key applications being addressed by the research


Secondary/tertiary-level students, researchers and academics interested in olfaction or its relationship to biological processes.

Table of Contents

    • Preface
    • Chapter One: Mammalian Olfactory Receptors: Molecular Mechanisms of Odorant Detection, 3D-Modeling, and Structure–Activity Relationships
      • Abstract
      • 1 Mammalian Olfactory Receptors: From Genes to Proteins
      • 2 Olfactory Receptor Activity Regulation: Homodimerization, Binding Cooperativity, and Allostery
      • 3 Olfactory Receptor 3D Modeling and Use for Virtual Screening
      • 4 Odorant Ligands Structure–Activity Relationships
    • Chapter Two: Olfactory Signaling in Insects
      • Abstract
      • 1 Introduction
      • 2 Insect Olfactory Receptors
      • 3 Role of Orco
      • 4 Final Remarks
      • Acknowledgments
    • Chapter Three: Advances in the Identification and Characterization of Olfactory Receptors in Insects
      • Abstract
      • 1 Introduction: The Molecular Bases of Odor Detection in Insects
      • 2 Identification of Complete Insect OR Repertoires Could Only Be Achieved by Genome and Transcriptome Sequencing
      • 3 Toward the Development of High Throughput Methods for the Functional Characterization of Insect ORs
      • 4 Conclusion
    • Chapter Four: Olfactory Disruption: Toward Controlling Important Insect Vectors of Disease
      • Abstract
      • 1 Introduction
      • 2 Detection of Olfactory Signals by Insect Vectors
      • 3 Discovery and Development of New Repellents
      • 4 Conclusion
    • Chapter Five: Pheromone Reception in Moths: From Molecules to Behaviors
      • Abstract
      • 1 Introduction
      • 2 Structure of Antennae
      • 3 Antennal ORNs
      • 4 Molecular Components of Chemical Reception
      • 5 Pheromone Receptors
      • 6 Pheromone-Binding Proteins
      • 7 General Odorant-Binding Proteins
      • 8 Sensory Neuron Membrane Proteins
      • 9 Antennal Lobe
      • 10 Behavior
      • Acknowledgments
    • Index

Product details

  • No. of pages: 144
  • Language: English
  • Copyright: © Academic Press 2015
  • Published: January 21, 2015
  • Imprint: Academic Press
  • eBook ISBN: 9780128029138
  • Hardcover ISBN: 9780128029121

About the Serial Volume Editor

Richard Glatz

Richard Glatz

Dr Richard Glatz has a broad background in Molecular Biology, Entomology & Ecology. He has worked with industry and government performing scientific research and project management.

In 2004, he completed a PhD at The University of Adelaide. That study involved characterisation of molecules employed by wasps to parasitise pest insects by suppressing their immunity. He then undertook post-doctoral research at CSIRO Molecular and Health Technologies developing drug-screening assays for compounds modulating the effect of G-protein-coupled Receptors.

From 2006-2013, Dr Glatz was a Senior Research Scientist at SARDI Entomology in South Australia. During this time he played major roles in a series of projects primarily in biosecurity and sustainability of production systems. One major project aimed to develop an olfactory biosensor of stored grain pests (winning of CRC Plant Biosecurity Committee awards for Innovation and Science Impact). In 2011, he published a comprehensive review (in Progress in Neurobiology) of approaches and technologies associated with using biological tissues, cells and molecules of vertebrates and invertebrates, to either de-orphan olfactory receptors, or as biological sensing elements in biosensor applications.

Some other achievements during this time were:

  • leading national Pine Aphid Biocontrol Project
  • leading Revegetation at a Property Scale Project investigating use of native vegetation in horticultural systems
  • leading work that validated the first known marker of prior irradiation in insects
  • leading work to characterise wasp venom for insect immune disrupting compounds
  • obtaining GRDC Innovation Award to develop aptamer detectors of fungal spores

Since 1998, Dr Glatz has been studying ecology of semi-arid/temperate systems in Australia, particularly mallee ecosystems. He has a close association with Kangaroo Island and has now produced the only insect collection specific to the island; it currently has over 30,000 specimens, with about 15,000 databased. In 2009, Dr Glatz discovered a family of primitive moth from the island that is new to science. This has resulted in an international study that has refined our knowledge of lepidopteran evolution. Additionally, he discovered a new genus of braconid wasp that parasitizes the moth.

In late 2013, Dr Glatz founded D’Estrees Entomology and Science Services, based on Kangaroo Island.

He is an Associate Editor in Entomology for the journal Scientia Agricola, and has reviewed a range of science manuscripts and research proposals. He also continues to hold affiliate/honourary positions with University of Adelaide, School of Agriculture, Food and Wine and the South Australian Museum, Terrestrial Invertebrates.

Affiliations and Expertise

D'Estrees Entomology & Science Services

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