Molecular Associations in Biology

Molecular Associations in Biology

Proceedings of the International Symposium Held in Celebration of the 40th Anniversary of the institute de Biology physico-Chimique (Foundation Edmond de Rothschild)

1st Edition - January 1, 1968

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  • Editor: Bernard Pullman
  • eBook ISBN: 9780323145022

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Description

Molecular Associations in Biology provides information pertinent to molecular biology. This book discusses several topics, including DNA replication, calculation of intermolecular energies, and thermodynamic parameters of polynucleotides. Organized into 35 chapters, this book starts with an overview of the specific association of the purine and pyrimidine bases in the nucleic acids, which provides the basis for storage, expression, and transmission of genetic information. This text then explores the secondary structures, interactions, and replication processes of nucleic acids. Other chapters consider the complex biological process of protein synthesis. This book discusses as well the methods of photodynamic action, which is significant in detecting energy transfer from dye to the biomolecule and identifying the free radicals produced. The final chapter deals with the macroscopic properties of molecular systems, which refer to such concepts as volume, mass, pressure, temperature, and pH. This book is a valuable resource for biophysicists, organic chemists, biochemists, and biologists.

Table of Contents


  • List of Contributors

    Preface

    Associations Moléculaires en Biologie: Théorie et Expérience. Propos d'Introduction

    Text

    Bibliographie

    Hydrogen Bonding between Purines and Pyrimidines

    I. Introduction

    II. Base Pairs in the Crystalline State

    III. Base Pairs in Solution

    IV. Conclusion

    References

    The Physicochemical Basis of Interactions of Nucleic Acid

    I. Association of Bases and Nucleosides in Aqueous Solutions

    II. Specific and Cooperative Interaction of the Nucleosides with the Complementary Polynucleotides

    III. Contribution of the 2'-Hydroxyl Group to the Conformation and Interaction of Nucleic Acids

    IV. Final Remarks

    References

    Base-Base Interactions in Nucleic Acids

    I. Components

    II. Single-Strand Polynucleotides

    III. Base Pairing

    IV. Multistrand Regions in Polynucleotides

    V. Conformation of Ribonucleic Acids

    VI. Codon-Anticodon Recognition

    References

    Oligonucleotide Interactions

    I. Hypochromicity

    II. Optical Rotatory Dispersion

    III. Circular Dichroism

    IV. Energy Transfer

    V. Effect of Chain Length

    VI. Nature of the Forces Involved

    VII. Hydrogen-Bonded Complexes

    VIII. Thermodynamic Stability and Tm

    IX. Ribosome-Messenger tRNA Interactions

    References

    Some Effects of Noncomplementary Bases on the Stability of Helical Complexes of Polyribonucleotides

    Text

    References

    Some Practical Improvements in the Calculation of Intermolecular Energies

    I. Introduction

    II. The Long-Range Interaction Energy

    III. The Interaction Energy at Short Distances

    IV. Conclusion

    References

    Physics of Protein Synthesis

    I. Introduction

    II. Interactions between Nucleotide Bases

    III. Unconstrained Case

    IV. DNA Replication

    V. DNA Replication in the Presence of Base Analogs

    References

    Kinetics of Helix Formation and Slippage of the dAT Copolymer

    I. Introduction

    II. Formation of Hairpin Helices

    III. Branching

    IV. Mechanism Proposed for Reiterative Synthesis

    V. Possible Mechanisms of Slippage

    VI. A System for Measuring the Rates of Elementary Processes in dAT Helix Formation

    VII. A Possible Slippage Reaction Observed with dAT Oligomers

    VIII. Conclusion

    IX. Appendix

    References

    Some Aspects of RNA Transcription

    I. Introduction—A Brief Review of RNA Transcription In Vitro

    II. Selective Transcription of DNA Templates

    References

    Influence of the Structure of Transfer RNA on Its Interaction with Enzymes and Divalent Cations

    I. Introduction

    II. Reactivity and Specificity in Various Enzymatic Reactions

    III. Measurement of Proton Relaxation Rates of Water at the Binding Sites of Manganese

    References

    The Interaction of Aromatic Hydrocarbons with Nucleic Acids and Their Constituents

    Text

    References

    On the Solubilization of Aromatic Carcinogens by Purines and Pyrimidines

    Text

    References

    The Interaction of Heterocyclic Compounds with DNA

    I. Introduction

    II. The Experimental Study of the Interaction of DNA and Heterocyclic Compounds

    III. Models for the Complex Formed by the Binding of Heterocyclic Molecules and Ions to DNA

    IV. Free Energy Calculations for Models Based on Intercalation and External, Edgewise Binding of Aminoacridines

    V. Discussion

    References

    Recherches Théoriques sur l'Intercalement des Aminoacridines dans l'ADN

    I. Introduction

    II. Théorie

    III. Les Interactions Verticales

    IV. Les Interactions Ioniques

    V. Conclusion

    Bibliographie

    Statistical Mechanical Analysis of Binding of Acridines to DNA

    I. Introduction

    II. General Procedure

    III. Two-State Models

    IV. Models of Competitive Modes of Binding

    References

    Alterations of T4 DNA Synthesis in the Presence of 9-Aminoacridine

    I. Intercalation in Mutagenesis

    II. Perturbation of DNA Synthesis

    III. The Relief from Acridine Inhibition

    IV. Discussion

    V. Summary

    References

    Interaction of Antibiotics with Nucleic Acids

    I. Daunomycin, Nogalamycin, and Cinerubin

    II. Chromomycin and Mithramycin

    III. Discussion

    References

    Effect of Light on Dyes and Photodynamic Action on Biomolecules

    I. Introduction

    II. Experimental Techniques

    III. Production of Free Radicals in Irradiated Dyes

    IV. Photodynamic Effects

    V. General Conclusions

    References

    Charge-Transfer Complexes in Biological Oxidations

    I. Introduction

    II. Charge-Transfer Association

    III. Discussion

    IV. Concluding Remarks

    References

    Charge-Transfer Complexes in Enzyme-Coenzyme Models

    I. Indole-Pyridinium Ion Interaction

    II. Indole: 1,4-Dihydronicotinamide Interaction

    III. Amino Acid-Pyridinium Interactions

    IV. Amino Acid Side Chains—1,4-Dihydronicotinamide Interactions

    V. Substituted Benzene-Pyridinium Interactions

    VI. Purine-Nicotinamide Interactions

    References

    Charge-Transfer Interactions in Certain Physiological Processes

    I. Introduction

    II. Vitamin B12

    III. Hematoporphyrin

    IV. General Conclusions

    References

    Complexes between Indole and Imidazole Derivatives of the Charge-Transfer Type

    I. Intermodular Indole-Imidazolium Complexes in Aqueous Solution

    II. Intramolecular Indole-Imidazolium Complexes in Model Compounds

    III. Fluorometric Detection of Histidine-Tryptophan Complexes in Proteins

    IV. Discussion

    References

    Nature of the Intramolecular Complex of Flavine Adenine Dinucleotide

    I. Introduction

    II. Experimental Findings

    III. Alterations in the Flavine Moiety

    IV. Alterations in the Adenosine Moiety

    V. Shape of Flavine Complexes

    References

    Molecular Complexes of Flavines

    I. Introduction

    II. pH Dependence of Complex Formation

    III. Complex Stoichiometry

    IV. Spectral Properties of Complexes

    V. Thermodynamics of Complex Formation

    VI. Solid-State Properties of Complexes

    VII. Modification of Flavine Properties by Complex Formation

    VIII. Biochemical Implications

    References

    Les Forces de Van der Waals-London dans les Complexes Dits de Transfert de Charge

    I. Introduction

    II. Expression de l'Énergie d'Interaction Intermoléculaire

    III. Calcul des Interactions de Van der Waals-London

    IV. Conclusion

    Bibliographie

    Solvent Effects on Molecular Associations

    I. Introduction

    II. Theory

    III. The Solvophobic Force

    IV. Discussion of some Applications

    V. Conclusion

    VI. Appendix. Nonpolar Part of the Van der Waals Potential between Two Molecular Groups Immersed in a Liquid

    References

    Solvent Polarity and Molecular Associations

    I. Introduction

    II. Experiments and Results

    III. Discussion

    IV. Conclusion

    References

    The Structure of Antibodies and the Antigen-Antibody Reaction

    Text

    References

    A New Allosteric Effect in the Reaction Cycle of Liver Alcohol Dehydrogenase

    Text

    References

    On the Mechanism of Binding Choline Derivatives to an Anticholine Antibody

    I. Introduction

    II. Materials and Methods

    III. Results and Discussion

    References

    Energy Transfer Methods in the Study of Ligand-Protein Interactions

    I. Introduction

    II. The System Anilinonaphthalene Sulfonate (ANS)-Bovine Serum Albumin (BSA)

    III. Ligand Distribution and Protein Fluorescence Yield

    IV. Fluorescence Polarization Observations

    V. Significance of Decrease of p0 with Number Bound

    VI. The Increase in Relaxation Time with Number Bound

    VII. Dependence of Energy Transfer with Excitation Wavelength in ANS

    References

    Optical Studies of Polypeptide-Solvent Interactions in Sulfuric Acid-Water Mixtures

    I. Introduction

    II. Experimental Findings

    III. Discussion

    References

    Phospholipid Membranes Are Necessarily Bimolecular

    I. Calculation of γo/r

    II. Can a Lipid Membrane Be Thicker Than Bimolecular

    III. Can a Lipid Membrane Be Thinner Than a Bilayer

    IV. The Equilibrium between Bilayers and Droplets

    V. Conclusion

    References

    Molecular Associations in Biology—A Brief Summary

    Text

    References

    Author Index

    Topical Subject Index

Product details

  • No. of pages: 592
  • Language: English
  • Copyright: © Academic Press 1968
  • Published: January 1, 1968
  • Imprint: Academic Press
  • eBook ISBN: 9780323145022

About the Editor

Bernard Pullman

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