Molecular Approach to Cancer Management

Molecular Approach to Cancer Management

1st Edition - June 15, 2017

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  • Author: Gajanan Sherbet
  • Paperback ISBN: 9780128128961
  • eBook ISBN: 9780128128978

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Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy.

Key Features

  • Covers all relevant topics with a defined aim of targeted therapy
  • Encompasses the basic aspects of cancer invasion and metastasis
  • Discusses signaling systems operating in normal cells and their deregulation in cancer cells
  • Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach


Cancer researchers; oncologists; molecular oncologists

Table of Contents

  • 1. Modulation of growth factor signaling in targeted therapy: Role of the epidermal growth factor family and their receptors
    2. The TGF-B family accessory type III receptor function in cancer progression
    3. Insulin-like growth factor signaling as a target to control tumor progression
    4. Angiogenesis in neoplasia and antiangiogenesis strategy in the control of tumor growth and metastasis
    5. On the trail of TRAIL in tumor growth and angiogenesis
    6. Hedgehog (Hh) signaling in EMT, CSCs and angiogenesis
    7. Hedgehog is involved in angiogenic signaling by angiopoietin-1
    8. Hippo signaling in cell proliferation, migration and angiogenesis
    9. Tumor suppression and inhibition of angiogenesis by TXNIP
    10. Suramin and polysulphonated naphthylureas as angiogenesis inhibitors
    11. Quercetin inhibits growth factor signaling: suppresses angiogenesis and cell migration in vitro
    12. Selenoproteins in cancer control
    13. Inhibitor of DNA binding proteins in angiogenesis
    14. Are there gains to be made in exploring anthrax lethal toxin (LeTx) as a tumor and an angiogenesis inhibitor?
    15. Small molecule inhibitors of angiogenesis and cell proliferation
    16. Control of tumor growth and angiogenesis by thalidomide and its analogues
    17. Endogenous inhibitors of angiogenesis
    18. Metformin and its antitumor attributes
    19. Statins in cancer biology
    20. The HMG (High mobility group) proteins in cancer progression
    21. MTAs in EMT activation and tumor and metastasis promotion
    22. S100A4 has potential benefits as a therapeutic target
    23. Notch Signaling in carcinogenesis
    24. Canonical and non-canonical activation of NF-κB in tumorigenesis
    25. Stem cells in cancer therapy
    26. Notable approaches to cancer immunotherapy

Product details

  • No. of pages: 352
  • Language: English
  • Copyright: © Academic Press 2017
  • Published: June 15, 2017
  • Imprint: Academic Press
  • Paperback ISBN: 9780128128961
  • eBook ISBN: 9780128128978

About the Author

Gajanan Sherbet

Dr. Gajanan V. Sherbet is Doctor of Science of London University and Fellow of the Royal College of Pathologists and the Royal Society of Chemistry. He is member of the editorial boards of many scientific and medical journals, and formerly editor of Experimental Cell Biology and Pathobiology. Dr. Sherbet’s major scientific interest is in cancer metastasis. He has focused on the role of growth factors and their signaling, and the calcium binding protein S100A4 in cell proliferation, cancer invasion and metastasis; also he is currently studying the potential of artificial neural networks for predicting breast cancer progression and prognosis. Dr. Sherbet has numerous scientific papers in international journals and has written and edited several books on cancer, such as Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy (2011) and Therapeutic Strategies in Cancer Biology and Pathology (2013), and e-books on the role of growth factors and their receptors in cancer therapy and therapeutic strategies in cancer biology and molecular pathology.

Affiliations and Expertise

Professor, Institute for Molecular Medicine, Huntington Beach CA, USA and Professor (visiting), School of Electrical and Electronic Engineering, University of Newcastle upon Tyne, UK

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