Modulation by Molecular Interactions

Modulation by Molecular Interactions

Current Topics in Cellular Regulation, Vol. 26

1st Edition - September 26, 1985

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  • Editors: Rodney L. Levine, Ann Ginsburg
  • eBook ISBN: 9781483217253

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Current Topics in Cellular Regulation, Volume 26: Modulation by Molecular Interactions covers various aspects of biochemical regulation that were presented in the International Symposium on the Molecular Basis of Cellular Regulation held at the National Institutes of Health on May 3-5, 1984. The book discusses the coordination and control of cellular metabolism and function, focusing on modulation by molecular interactions. Biochemists, molecular biologists, geneticists, microbiologists, and physiologists will find the book invaluable.

Table of Contents

  • Contributors



    I. Cell Biology

    1. The LDL Receptor and HMG-CoA Reductase—Two Membrane Molecules That Regulate Cholesterol Homeostasis

    2. The Cellular Entry of EGF and Transferrin: A Problem in Intracellular Sorting

    3. Receptor-Mediated Transport of Acid Hydrolases to Lysosomes

    4. Diagnostic and Therapeutic Applications of Sphingolipid Hydrolyzing Enzymes

    5. Platelet-Derived Growth Factor: Structure, Function, and Roles in Normal and Transformed Cells

    6. Regulation of Glutamine Synthetase in Cultured 3T3-L1 Adipocytes by Insulin, Hydrocortisone, and Cyclic AMP

    7. Scrapie Prions, Brain Amyloid, and Senile Dementia

    8. Coupled Ionic and Enzymatic Regulation of Sperm Behavior

    9. Regulation of Cell Interactions during Skeletal Muscle Development

    10. Regulation of the Immune Response in Man by a Cascade of Interactive T Lymphocytes

    11. From Membrane to Molecule with the lac Permease of Escherichia coli

    12. Glutamine Synthetase from Pseudomonas fluorescens: A Tool for Studying Changes in Cell Permeability and Enzyme Regulation

    13. Modulation of Polar Lipid Composition by Aliphatic Chain Unsaturation in Bacteria

    II. Protein Interactions

    14. On Conformational Changes in the Regulatory Enzyme Aspartate Transcarbamoylase

    15. Active-Site Ligand Binding and Subunit Interactions in Glutamine Synthetase from Escherichia coli

    16. Biophysical Studies of Escherichia coli Glutamine Synthetase

    17. The Regulation of Actin and Myosin by ATP

    18. Change in NAD+/NADH Content of S-Adenosyl-L-Homocysteine Hydrolase upon NAD+ Reversible Inactivation by cAMP and 2'- Deoxyadenosine

    19. Effectors of Rat Lung cGMP Binding Protein-Phosphodiesterase

    20. Thermostabilization of Bacillus caldolyticus Glutamine Synthetase by Intrinsic and Extrinsic Factors

    21. The Role of Pyridoxal 5'-Phosphate in Phosphorylase Catalysis

    22. Bioregulation of Binding and Dynamics: The Cytochrome P-450CAM Model

    23. Fatty Acid Synthase: Elementary Steps in Catalysis and Regulation

    24. Multienzyme Complexes of Mammalian Aminoacyl-tRNA Synthetases

    25. The Pyruvate Dehydrogenase Complex in Dictyostelium discoideum

    III. Metabolic Pathways

    26. Pathway of 5-Aminovalerate Degradation by Clostridium aminovalericum

    27. Inorganic Pyrophosphate and Polyphosphates as Sources of Energy

    28. The Role of Pyridine Nucleotides in Regulating Cellular Metabolism

    29. The Fall and Rise of Cellular Glutathione Levels: Enzyme-Based Approaches

    30. The Effects of Protein or Amino Acid Intake on the Nitrogen Balance and Antitumor Activity of Glutaminase Treatment

    31. On the Regulation of Deoxyhbonucleotide Synthesis

    32. Completion of the Degradation Scheme for Nicotinic Acid by Clostridium barkeri

    33. Mechanisms of Exogenous Purine Nucleotide Utilization in Bacillus cereus

    34. Pyrimidine Nucleoside-Catabolizing Enzymes in Escherichia coli B

    IV. Gene Expression

    35. Recent Biochemical and Genetic Studies on the Amino Acid Biosynthetic Pathway of the Aspartate Family in Escherichia coli

    36. Regulation of Antibiotic Resistance in Bacteria: The Chloramphenicol Acetyltransferase System

    37. An in Vitro System to Measure Gene Expression Based on Dipeptide Synthesis

    38. Regulation of Enzymes under Nitrogen Control in Pseudomonas aeruginosa

    39. Catabolism and Nitrogen Control in Escherichia coli

    40. Regulation of Gene Expression of Translation Components in Escherichia coli: Initiation Factors and Aminoacyl tRNA Synthetases

    41. Regulatory Features of Spore Development in Bacillus subtilis

    42. Bacterial Gene Expression and Biotechnology


    Cumulative Contributors Index

    Contents of Recent Volumes

Product details

  • No. of pages: 588
  • Language: English
  • Copyright: © Academic Press 1985
  • Published: September 26, 1985
  • Imprint: Academic Press
  • eBook ISBN: 9781483217253

About the Editors

Rodney L. Levine

Ann Ginsburg

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