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Modern Approaches in Drug Discovery - 1st Edition - ISBN: 9780128153833, 9780128153840

Modern Approaches in Drug Discovery, Volume 610

1st Edition

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Serial Volume Editor: Charles Lesburg
Hardcover ISBN: 9780128153833
eBook ISBN: 9780128153840
Imprint: Academic Press
Published Date: 1st November 2018
Page Count: 337
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Table of Contents

1. Risk Management in Early Discovery Medicinal Chemistry
Gurpreet Singh, Jayme L. Dahlin and Michael A. Walters
2. Target Identification Using Chemical Probes
Moses Moustakim, Suet Ling Felce, Nancy Zaarour, Gillian Farnie, Fiona E. McCann and Paul E. Brennan
3. Mining the Microbiome for Drug Targets
Qi Wang, Fangming Yang and Huijue Jia
4. Screening Library Design
Stephanie Kay Ashenden
5. Design of a Fragment Screening Library
Ashley Taylor, Bradley C. Doak and Martin J. Scanlon
6. Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond
Jacob Valentine and Ali Tavassoli
7. A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays
Christian Bergsdorf and Kirk Wright
8. Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and Screening
Tracy A. Young, Ben Moree, Margaret T. Butko, Bason Clancy, Mary Geck Do, Tarun Gheyi, John Strelow, Juan J. Carrillo and Joshua Salafsky
9. An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives
Becky S. Leifer, Shelby K. Doyle, André Richters, Helen L. Evans and Angela N. Koehler
10. High Content, Phenotypic Assays and Screens for Compounds Modulating Cellular Processes in Primary Neurons
Miklos Kepiro, Boglarka H. Varkuti and Ronald L. Davis
11. Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening
Patrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, Jose Brandao-Neto, Tobias Krojer and Frank von Delft
12. Hit-to-Lead: Hit Validation and Assessment
Kirk E. Hevener, JinHong Ren, Russell Pesavento, Kiira Ratia, Hyun Lee and Michael E. Johnson
13. Knowledge-Based Approaches to Off-Target Screening
Daniel R. McMasters


Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Methods in Enzymology series
  • Updated release includes the latest information on the Intrinsically Disordered Proteins


Addressed to all specialists in this field


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© Academic Press 2018
1st November 2018
Academic Press
Hardcover ISBN:
eBook ISBN:

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About the Serial Volume Editor

Charles Lesburg

Dr. Charles Lesburg works at Merck Research Laboratories, Boston, MA, USA

Affiliations and Expertise

Merck Research Laboratories, Boston, MA, USA