Modern Approaches in Drug Discovery - 1st Edition - ISBN: 9780128153833, 9780128153840

Modern Approaches in Drug Discovery, Volume 610

1st Edition

Serial Volume Editors: Charles Lesburg
eBook ISBN: 9780128153840
Hardcover ISBN: 9780128153833
Imprint: Academic Press
Published Date: 1st November 2018
Page Count: 337
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Table of Contents

    1. Risk Management in Early Discovery Medicinal Chemistry
    2. Gurpreet Singh, Jayme L. Dahlin and Michael A. Walters

    3. Target Identification Using Chemical Probes
    4. Moses Moustakim, Suet Ling Felce, Nancy Zaarour, Gillian Farnie, Fiona E. McCann and Paul E. Brennan

    5. Mining the Microbiome for Drug Targets
    6. Qi Wang, Fangming Yang and Huijue Jia

    7. Screening Library Design
    8. Stephanie Kay Ashenden

    9. Design of a Fragment Screening Library
    10. Ashley Taylor, Bradley C. Doak and Martin J. Scanlon

    11. Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond
    12. Jacob Valentine and Ali Tavassoli

    13. A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays
    14. Christian Bergsdorf and Kirk Wright

    15. Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and Screening
    16. Tracy A. Young, Ben Moree, Margaret T. Butko, Bason Clancy, Mary Geck Do, Tarun Gheyi, John Strelow, Juan J. Carrillo and Joshua Salafsky

    17. An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives
    18. Becky S. Leifer, Shelby K. Doyle, André Richters, Helen L. Evans and Angela N. Koehler

    19. High Content, Phenotypic Assays and Screens for Compounds Modulating Cellular Processes in Primary Neurons
    20. Miklos Kepiro, Boglarka H. Varkuti and Ronald L. Davis

    21. Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening
    22. Patrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, Jose Brandao-Neto, Tobias Krojer and Frank von Delft

    23. Hit-to-Lead: Hit Validation and Assessment
    24. Kirk E. Hevener, JinHong Ren, Russell Pesavento, Kiira Ratia, Hyun Lee and Michael E. Johnson

    25. Knowledge-Based Approaches to Off-Target Screening

Daniel R. McMasters


Description

Modern Approaches in Drug Discovery, Volume 611, the latest release in the Methods in Enzymology series, highlights new advances in the field, with this new volume presenting interesting chapters on topics such as Target Identification and Validation, Cell Painting/High Content Imaging, Target ID using chemical probes, Mining the microbiome for targets, Data driven approaches for diversity and drug-likeness, Affinity-based screening, Fragment screening (X-ray), Array-based approaches, Hit-to-lead: assessment and improvement of drug-like properties, Hit assessment and prioritization, Lead Optimization: fine tuning and risk mitigation, and more.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Methods in Enzymology series
  • Updated release includes the latest information on the Intrinsically Disordered Proteins

Readership

Addressed to all specialists in this field


Details

No. of pages:
337
Language:
English
Copyright:
© Academic Press 2018
Published:
Imprint:
Academic Press
eBook ISBN:
9780128153840
Hardcover ISBN:
9780128153833

Ratings and Reviews


About the Serial Volume Editors

Charles Lesburg Serial Volume Editor

Dr. Charles Lesburg works at Merck Research Laboratories, Boston, MA, USA

Affiliations and Expertise

Merck Research Laboratories, Boston, MA, USA