Models of Protection Against HIV/SIV

Models of Protection Against HIV/SIV

Models of Protection Against HIV/SIV

1st Edition - November 2, 2011

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  • Editors: Gianfranco Pancino, Guido Silvestri, Keith Fowke
  • eBook ISBN: 9780123877161
  • Hardcover ISBN: 9780123877154

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A successful vaccine for the prevention and/or immunotherapy against HIV/AIDS is one of the prominent challenges of the 21st century. To date, all human vaccine trials against this virus/disease have resulted in failure, or at best have shown very low efficacy. The scientific community dealing with HIV/AIDS has unanimously proposed a focus on basic science, with the intention of identifying correlates of protection that can serve as guides in developing and evaluating vaccine preparation. However, Nature seems to have already found several ways of dealing with infections by HIV and related primate lentiviruses, either by resisting infection or, once infected, avoiding immune damage and immunodeficiency. Models of Protection Against HIV/SIV will allow for an in-depth reflection on the perspectives for vaccine and therapy research derived from important recent studies. It will be authored by some of the most well known specialists in the field of HIV resistance/protection: including F. Barré-Sinoussi (2008 Nobel Prize for Medicine winner), B. Walker, S. Rowland-Jones, A. Telenti, M. Lederman and F. Plummer. This book is structured in a unique way, looking at three models of resistance/protection separately and then comparing the models against one another to provide its readership with a detailed examination of the research that is most predominant in the search for a vaccine. This structure presents the information in an easy-to-understand format and gives the book a cross-discipline appeal -- an important reference for those in the scientific community, medical care, public health and academia alike.

Key Features

  • Provides extensive descriptions and comparisons on the different models of protection agains HIV/AIDS
  • Comprehensive writing and illustrations
  • Contributors are among the most eminent specialists in the field


The primary audience for this work is HIV/AIDS physicians, researchers and policy makers in academia, industry and government, as well as, medical and graduate students looking to further their understanding of HIV/AIDS vaccine efforts

Table of Contents

  • Contributors



    Chapter 1. Natural SIV Infection

    Chapter 2. Natural SIV Infection

    Chapter 3. Implications for Therapy


    Chapter 4. Are Some People Protected Against HIV Infection?

    Chapter 5. The Genital Mucosa, the Front Lines in the Defense Against HIV

    Chapter 6. Host Genetics and Resistance to HIV-1 Infection

    Chapter 7. The Immune System and Resisting HIV Infection


    Chapter 8. Definition, Natural History and Heterogeneity of HIV Controllers

    Chapter 9. Residual Viremia and Viral Reservoirs in Elite Controllers

    Chapter 10. Immune Responses Associated to Viral Control

    Chapter 11. Immune Mechanisms of Viral Control in HIV-2 Infection


    Chapter 12. Genetic Associations with Resistance to HIV-1 Infection, Viral Control and Protection Against Disease



Product details

  • No. of pages: 360
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: November 2, 2011
  • Imprint: Academic Press
  • eBook ISBN: 9780123877161
  • Hardcover ISBN: 9780123877154

About the Editors

Gianfranco Pancino

Affiliations and Expertise

INSERM and Institut Pasteur – Regulation of Retroviral Infections Unit, Paris, France

Guido Silvestri

Professor Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA

Chief, Division of Microbiology and Immunology, Yerkes National Primate Research Center

Georgia Research Alliance Eminent Scholar in Comparative Pathology, Emory University

Affiliations and Expertise

Emory University and Yerkes National Primate Research Center, Atlanta, GA, USA

Keith Fowke

Affiliations and Expertise

University of Manitoba, Winnipeg, Manitoba, Canada

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