Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies

Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies

1st Edition - January 18, 2022

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  • Author: Tetsuya Watanabe
  • Paperback ISBN: 9780323988032
  • eBook ISBN: 9780323972703

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Description

Modeling Electrochemical Dynamics and Signaling Mechanisms in Excitable Cells with Pathological Case Studies covers the neuronal cell communication system in excitable cells, recognizing the most relevant mechanisms of cell communication. Along with new findings in biotechnology, medicine and pathological cases for clinicians, the book highlights electrochemical potential in  living nerve and muscle cells. Written for physiological scientists, pharmaceutical scientists, medical doctors, biologists and physicists, this book an essential read for a real understanding of the signals as we see them.

Key Features

  • Covers neuronal cell communication systems in excitable cells
  • Presents new findings in biotechnology that are being applied in medicine and pathological cases
  • Covers mathematical and physical bases for readers without background in these fields

Readership

Physiological scientists, Pharmaceutical scientists, Medical doctors, Biologists and Physicists. Graduate and undergraduate students

Table of Contents

  • Cover image
  • Title page
  • Table of Contents
  • Copyright
  • Preface
  • Acknowledgments
  • Chapter 1: Introduction
  • Abstract
  • 1.1: Molecular interaction and increases in entropy associated with diffusion
  • 1.2: Functions of the cell membrane
  • 1.3: Oscillation of electrochemical potential in exciting living cells
  • 1.4: Physiological functions regulated by diffusion, attraction, and binding of ligands to their receptors
  • 1.5: Basic mechanism of automaticity and its modulation
  • 1.6: Medical applications
  • 1.7: Conclusions
  • References
  • Chapter 2: Statistical dynamics and molecular interaction
  • Abstract
  • 2.1: Introduction to statistical thermodynamics
  • 2.2: Energy distribution in a solid
  • 2.3: Energy exchange among interacting solids
  • 2.4: Statistical definition of entropy and the Boltzmann distribution to oscillators in a solid
  • 2.5: Interacting gaseous molecules in a space
  • 2.6: Diffusion of interacting molecules
  • 2.7: Conclusions
  • References
  • Chapter 3: Function of membrane and protein synthesis in the cell
  • Abstract
  • 3.1: Introduction
  • 3.2: Molecular shape of proteins
  • 3.3: Phospholipid bilayer cell membrane
  • 3.4: Bulk transport, endocytosis, and exocytosis
  • 3.5: Production, glycosylation, and transport of proteins
  • 3.6: Columnar transmembrane proteins
  • 3.7: DNA and RNA
  • 3.8: Protein synthesis in living cells
  • 3.9: Gene cloning and expression vectors
  • 3.10: Polymerase chain reaction
  • 3.11: Reverse transcription polymerase chain reaction
  • 3.12: Exosomal communication
  • 3.13: Conclusions
  • References
  • Chapter 4: Redox reactions and ATP synthesis in the cell
  • Abstract
  • 4.1: Introduction
  • 4.2: Shielding effects
  • 4.3: Electronegativity
  • 4.4: Regulation of cell's function via signaling molecules
  • 4.5: Redox reactions between molecules with an atom of different electronegativity
  • 4.6: Synthesis of ATP driven by electrochemical potential
  • 4.7: Relationship between electric work and Gibbs free energy
  • 4.8: Electric potential difference caused by electron transport in mitochondria
  • 4.9: ATP consumption in the cell
  • 4.10: ATP deficiency in the heart
  • 4.11: Conclusions
  • References
  • Chapter 5: Resting electric potential and ionic currents in the cell
  • Abstract
  • 5.1: Introduction
  • 5.2: Diffusion of ions
  • 5.3: Leak channels
  • 5.4: Ion selectivity of leak channels
  • 5.5: Na+-K+ pump driven by ATP
  • 5.6: Resting membrane potential caused by Na+-K+ ATPase and selective ion permeability
  • 5.7: Ionic currents driven by electrochemical forces
  • 5.8: Derivation of the Goldman equation
  • 5.9: Ca2 + oscillation in the RyR2 channel and rhythmic depolarization in the cytosol
  • 5.10: Conclusions
  • References
  • Chapter 6: Electrochemical conduction in neurons and neuronal communications
  • Abstract
  • 6.1: Introduction
  • 6.2: Ligand-gated ion channels and neurotransmitters
  • 6.3: Graded potential in the cell body
  • 6.4: Switching a neuron between resting state and exciting state
  • 6.5: Structure and function of voltage-gated Na+and K+ channels
  • 6.6: Action potential in neuron
  • 6.7: Velocity of action potential conduction in neurons
  • 6.8: Deriving of the cable equation
  • 6.9: Damped oscillatory voltage change in the exciting axon
  • 6.10: Neuronal communication of living cells
  • 6.11: Nerve injuries
  • 6.12: Conclusions
  • References
  • Chapter 7: Electrochemical signaling mechanism in cardiac muscle
  • Abstract
  • 7.1: Introduction
  • 7.2: Function of inwardly rectifying K+ channels in the cardiac myocytes
  • 7.3: G protein-coupled receptors in the heart
  • 7.4: Ryanodine receptor 2 channels
  • 7.5: Sodium-calcium exchanger
  • 7.6: HCN cation channels and modulation of the cardiac rhythmicity
  • 7.7: Gap junctional conduction
  • 7.8: Action potential in the heart
  • 7.9: Cyclic depolarization of the pacemaker cells and modulation by postganglionic autonomic nerves
  • 7.10: Amplification and stabilization of signals
  • 7.11: Conduction between the atrium and ventricle
  • 7.12: Conclusions
  • References
  • Chapter 8: Mechanism of muscle contraction and disorder
  • Abstract
  • 8.1: Introduction
  • 8.2: Contraction of skeletal muscle and neuromuscular junction disorder
  • 8.3: Joint pain and weakness of the muscle
  • 8.4: Rhythmic contractions of cardiac muscle
  • 8.5: Contraction and dilation of smooth muscle
  • 8.6: Oscillatory contractions of intestine
  • 8.7: Vasodilation
  • 8.8: Bronchoconstriction and bronchodilation
  • 8.9: Conclusions
  • References
  • Chapter 9: Gas exchange and respiratory insufficiency
  • Abstract
  • 9.1: Introduction
  • 9.2: Gas exchange between blood and organs
  • 9.3: Regulation of respiration
  • 9.4: Diffusion across respiratory membrane
  • 9.5: Airflow in the lungs and pulmonary resistance
  • 9.6: Functional residual capacity and pulmonary compliance
  • 9.7: Pulmonary resistance and compliance during inhalation of 5% oxygen
  • 9.8: Pneumonia
  • 9.9: Conclusions
  • References
  • Chapter 10: Electrochemical mechanism of arrhythmias and antiarrhythmic drugs
  • Abstract
  • 10.1: Impulse conduction in the heart
  • 10.2: Disorder of impulse generation and ECG
  • 10.3: Incidence of premature contractions
  • 10.4: Cardiac arrhythmias
  • 10.5: Experimental induction of ventricular tachycardia
  • 10.6: Antiarrhythmic drugs
  • 10.7: Discussion
  • 10.8: Conclusions
  • References
  • Reference data
  • Index

Product details

  • No. of pages: 244
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: January 18, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323988032
  • eBook ISBN: 9780323972703

About the Author

Tetsuya Watanabe

Dr. Tetsuya Watanabe is the President of Watanabe Institute of Mathematical Biology and Watanabe Clinic of Oral Surgery in Hamamatsu, Japan. He graduated from Kanagawa Dental College and holds a DDS degree in dental medicine. He received Postgraduate Training and Fellowship Appointments and successively Faculty Appointments of Associate and Assistant Professor at the Department of Pharmacology, Medical School, University of Pennsylvania, in Philadelphia, USA. Dr. Watanabe is the recent author of Biophysical Basis of Physiology and Calcium Signaling Mechanism in Cardiac and Smooth Muscle, published by Elsevier/Academic Press in 2018.

Affiliations and Expertise

President, Watanabe Institute of Mathematical Biology and Watanabe Clinic of Oral Surgery, Japan

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