Mobile Genetic Elements

Mobile Genetic Elements

1st Edition - January 1, 1983

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  • Editor: James Shapiro
  • eBook ISBN: 9780323143196

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Mobile Genetic Elements introduces the nonspecialist to the biology and genetics of mobile elements. It attempts to make the biochemistry of DNA rearrangements more accessible to embryologists and evolutionists, and to illuminate the related developmental cycles to the biochemist. The book also shows how natural the activity of mobile elements can be in diverse biological situations. The chapters describe several well-studied cases in which genetic determinants—often identified as specific nucleic acid sequences—repeatedly change their positions within or between cellular genomes. Because their genomic positions are not fixed, these determinants may conveniently be classed together under the rubric of mobile genetic elements. The book begins with a discussion of maize controlling elements. This is followed by separate chapters on the bacteriophages λ and Mu; nonviral mobile elements in bacteria; transposable Ty elements in brewer's yeast; Drosophila transposable element; and hybrid dysgenesis. Subsequent chapters cover vertebrate retroviruses; Agrobacterium oncogenesis in plants; flagellar phase variation in Salmonella; yeast mating type; and surface antigenic variation in trypanosomes.

Table of Contents

  • Contributors

    Genomic Reorganization in Cell Lineages

    1. Controlling Elements in Maize

    I. Introduction

    II. Overview of Maize Controlling Elements

    III. The Ac-Ds Controlling Element Family

    IV. The Spm Controlling Element Family

    V. The Origin of Controlling Elements

    VI. Discussion


    2. Bacteriophage λ

    I. The λ Life Cycle

    II. Mechanism of Insertion and Excision

    III. Regulation of Integration Genes

    V. Comparative Properties of Phages that Insert by Reciprocal Site-Specific Recombination

    V. Reciprocal Recombination as a Transposition Mechanism

    VI. Evolution of λ and Its Relation to Host Evolution


    3. Phage Mu: Transposition as a Life-Style

    I. Introduction

    II. Mu as a Temperate Phage

    III. Mu as a Transposable Element

    IV. D108

    V. Mu and Host Factors Involved in Transposition-Replication


    4. Prokaryotic IS Elements

    I. Introduction

    II. Discussion of Knowledge and Concepts

    III. Interpretation of Available Data

    IV. DNA Rearrangements and Gene Transfer Attributable to IS Elements

    V. Conclusions, Speculations, and Open Questions


    5. Tn3 and Its Relatives

    I. Introduction

    II. Element-Specific Recombination

    III. The Genetic Organization of Tn3

    IV. Mechanism of Transposition

    V. IS 101 and Tn957: The Degenerate Transposons

    VI. The Tn507/Tn721 Subgroup

    VII. Transposition Immunity


    6. Transposon Tn10

    I. Introduction

    II. Transposition of Tn10 as a Discrete Unit

    III. Genetic Organization of Tn10

    IV. Genetic Analysis of Tn10 Transposition

    V. Genetic Organization of Tn70-Right

    VI. Role of the Host in Tn10 Transposition

    VII. Mechanism of Tn10 Transposition

    VIII. Tn10-Associated Excision

    IX. Tn10 as a Substrate for Homologous Recombination


    7. Transposable Elements in Yeast

    I. Introduction

    II. Transposition of Ty Elements

    III. Catalog of Ty Elements

    IV. Heterogeneity of Ty Elements

    V. Heterogeneity of δ Sequences

    VI. Heterogeneity in the Distribution of Ty Elements

    VII. Recombination between Ty and δ Sequences

    VIII. Ty Transcription

    IX. Ty Effects on Gene Expression

    X. Control of Tys

    XI. Summary and Conclusions


    8. Dispersed Repetitive DNAs in Drosophila

    I. Introduction

    II. copia-Like Elements

    III. Foldback Elements

    IV. Ρ Elements

    V. Other Dispersed Repetitive Families

    VI. Evolution of Drosophila Transposable Elements and Their Relationship to the Rest of the Genome


    9. Hybrid Dysgenesis Determinants

    I. Introduction

    II. Phenomenology of Hybrid Dysgenesis

    III. Inheritance of the Chromosomal Components

    IV. Inheritance of the Maternal Regulatory Components

    V. Interactions between the Two Components

    VI. Regulation of I and Ρ Elements

    VII. Hybrid Dysgenesis and Evolution


    10. Retroviruses

    I. Introduction

    II. The Properties of Retroviruses

    III. Proviruses as Movable Genetic Elements

    IV. Prospects


    11. Agrobacterium Tumor Induction

    I. Crown Gall: Agrobacterium—Plant-Cell Interaction

    II. Genetic and Functional Characteristics of Different Types of Ti Plasmids

    III. T-DNA Transfer from Plasmids to the Nucleus of Plant Cells

    IV. T-DNA as a New Chromosomal Locus in Transformed Plant Cells

    V. General Conclusions


    12. Phase Variation and Related Systems

    I. Introduction

    II. The Genetics of Phase Variation

    III. The Molecular Basis of Phase Variation

    IV. Bacteriophage Mu

    V. Some Other Site-Specific Recombination Systems

    VI. Evolution of the Phase Variation System

    VII. Functional Significance


    13. Mating-Type Genes of Saccharomyces cerevisiae

    I. Introduction

    II. The Mating-Type Locus

    III. Mating-Type Conversions

    IV. Expression of the Silent Genes without Transposition

    V. Mechanism of Mating-Type Switching

    VI. Possible Mechanisms of Transposition of Yeast Mating-Type Genes


    14. Antigenic Variation in Trypanosomes

    I. Introduction

    II. The Basic Biology of Trypanosomes and Antigenic Variation

    III. VSG Messenger RNAs and VSG Genes

    IV. The Expression of Some VSG Genes Controlled by a Duplication-Transposition

    V. VSG Gene Rearrangements Not Linked to Expression

    VI. Antigenic Variation in Protozoa Other than Trypanosomes

    VII. Summary and Outlook



Product details

  • No. of pages: 704
  • Language: English
  • Copyright: © Academic Press 1983
  • Published: January 1, 1983
  • Imprint: Academic Press
  • eBook ISBN: 9780323143196

About the Editor

James Shapiro

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