Minimized Cardiopulmonary Bypass Techniques and Technologies

1st Edition

Print ISBN: 9781845698003
eBook ISBN: 9780857096029
Imprint: Woodhead Publishing
Published Date: 19th April 2012
Page Count: 272
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Traditional cardiopulmonary bypass (CPB) techniques have suffered from a number of disadvantages including haemodilution, inflammation and post-operative bleeding. Minimised cardiopulmonary bypass techniques use developments in perfusion technology to significantly reduce foreign surface-blood interactions to make bypass simpler and safer. This important book reviews key developments and issues relating to this promising technology.

Part one covers the broad range of CPB pathophysiology, including anticoagulant protocols, the impact of CPB circuit surfaces, optimal haemodilution levels, and the important issue of CPB-induced systemic inflammatory response syndrome. Part two focuses on the issues of the new equipment developed for mini-CPB, optimal myocardial protection protocols and CPB perfusate options. Part three discusses clinical issues, including patient selection, coronary and valve surgery protocols and, among others, paediatric patients.

With its distinguished editors and international team of expert contributors, Minimized cardiopulmonary bypass techniques and technologies is a valuable reference for cardiac surgery teams and those researching this important technology.

Key Features

  • Covers a broad range of cardiopulmonary bypass (CPB) pathophysiology, including anticoagulant protocols, the impact of CPB circuit surfaces and optimal haemodilution levels
  • Focuses on new equipment specially developed for minimized-CPB and myocardial protection protocols
  • Discusses clinical issues, including patient selection


Clinicians, especially those concerned with cardiology.

Table of Contents

Contributor contact details


Chapter 1: Historical development of minimised cardiopulmonary bypass


1.1 Introduction and historical perspective

1.2 Cardiopulmonary bypass: from pioneering to refinement

1.3 Cardiopulmonary bypass: does size matter?

1.4 Conclusions

Chapter 2: Anticoagulation protocols for minimized cardiopulmonary bypass


2.1 Introduction: blood activation during cardiac surgery with cardiopulmonary bypass (CPB)

2.2 Anticoagulation during CPB: basic principles and historical notes

2.3 Heparin-bonded surfaces and other biocompatible treatments

2.4 Reduced systemic heparinization (RSH)

2.5 Contraindications

2.6 Future trends

Chapter 3: Minimized extracorporeal circulation: physiology and pathophysiology


3.1 Introduction: basic principles

3.2 The inflammatory cascade and biomarkers

3.3 Conclusions

Chapter 4: Blood–surface interface in miniaturised extracorporeal circulation systems


4.1 Introduction

4.2 Blood–surface contact in cardiopulmonary bypass (CPB)

4.3 Clinical benefits of miniaturised extracorporeal circulation systems

Chapter 5: Hemodilution: physiology and pathophysiology


5.1 Introduction

5.2 Basic physiology and pathophysiology of hemodilution

5.3 Microvascular alterations with hemodilution

5.4 Hemodilution and cardiopulmonary bypass (CPB)

5.5 Determinants of tissue oxygenation – functional capillary density (FCD)

5.6 Conclusions

Chapter 6: Inflammatory response and minimized cardiopulmonary bypass


6.1 Introduction

6.2 Cardiopulmonary bypass (CPB)-induced inflammatory cascade

6.3 Pharmacological antioxidants for CPB: impact on biochemical and clinical outcomes


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© Woodhead Publishing 2012
Woodhead Publishing
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The book is comprehensive in its scope and authoritative in the experience of its chapter authors. I commend the book to all members of cardiac surgery teams - surgeons, cardiologists, anaesthetists and perfusionists., Professor Ken Taylor, Emeritus Professor of Cardiac Surgery, Imperial College and The Hammersmith Hospital, London (from the Foreword)