Microfluidics for Pharmaceutical Applications

Microfluidics for Pharmaceutical Applications

From Nano/Micro Systems Fabrication to Controlled Drug Delivery

1st Edition - October 12, 2018

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  • Editors: Helder Santos, Dongfei Liu, Hongbo Zhang
  • Paperback ISBN: 9780128126592
  • eBook ISBN: 9780128126608

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Microfluidics for Pharmaceutical Applications: From Nano/Micro Systems Fabrication to Controlled Drug Delivery is a concept-orientated reference that features case studies on utilizing microfluidics for drug delivery applications. It is a valuable learning reference on microfluidics for drug delivery applications and assists practitioners developing novel drug delivery platforms using microfluidics. It explores advances in microfluidics for drug delivery applications from different perspectives, covering device fabrication, fluid dynamics, cutting-edge microfluidic technology in the global drug delivery industry, lab-on-chip nano/micro fabrication and drug encapsulation, cell encapsulation and delivery, and cell- drug interaction screening. These microfluidic platforms have revolutionized the drug delivery field, but also show great potential for industrial applications.

Key Features

  • Presents detailed coverage on the fabrication of novel drug delivery systems with desired characteristics, such as uniform size, Janus particles, and particular or combined responsiveness
  • Includes a variety of case studies that explain principles
  • Focuses on commercialization, cost, safety, society and educational issues of microfluidic applications, showing how microfluidics is used in the real world


This book will be suitable for Masters and PhD students and for those in the industry.

In addition, the book should appeal to a segment of academic scientists at all levels, from graduate students to professors, who work in related fields.

Table of Contents

  • Foreword
    Hélder A. Santos

    Section I: Principle of microfluidics
    1. Lab-on-a-Chip technology and microfluidics
    Senentxu Lanceros, Antonio Francesko & Vanessa F. Cardoso
    2. Fluid properties and hydrodynamics of microfluidic systems
    Yinghe He, David Wibowo & Chun-Xia Zhao
    3. Diffusion and mixing in microfluidic device
    Jing Fan, Shuaijun Li, Ziqian Wu & Zi Chen
    4. Microfluidic production of multicomponent multiple emulsions
    Masatoshi Maeki

    Section II: Microfluidics for drug delivery applications
    5. Microfabrication and Microfluidic Devices for Drug Delivery
    Manabu Tokeshi, Masatoshi Maeki a& Nicola Kimura
    6. Lab-on-a-chip preparation routes for organic nanomaterials for drug delivery
    Enza Torino & Enza Torino
    7. Microfluidic mixing and devices for preparing nanoparticulate drug delivery systems
    Dongfei Liu, Yuezhou Zhang, Hongbo Zhang & Hélder A. Santos
    8. Microfluidic production of inorganic nanomaterials for biomedical applications
    Manuel Arruebo & Victor Sebastian
    9. Lab-on-a-chip synthesis of microparticles for drug encapsulation and controlled release
    Liang-Yin Chu & Xiaojie Ju
    10. Microfluidic technologies for local drug delivery
    Shrike Zhang & Shabir Hassan
    11. Droplet-based microfluidics for cell encapsulation and delivery
    Dong Chen, Zeyong Sun & Ran Chen
    12. Antibody discovery using microfluidic systems
    Linas Mazutis, Greta Stonyte & Karolis Simutis
    13. Single-cell screening using microfluidic systems
    Linas Mazutis, Juozas Nainys & Valdemaras Milkus

    Section III: Microfluidics for analysis and drug delivery
    14. Lab-on-a-chip techniques for high throughput proteomics and drug discovery
    Nauman Khalid, Sania Arif, Isao Kobayashic & Mitsutoshi Nakajimac
    15. Microfluidics for chemical analysis and sample manipulation for pharmaceutical applications
    Tina Marjukka Sikanen

    Section IV: Future prospective and commercialization of microfluidic techniques
    16. Future of microfluidics in research and in the market
    Adam Bohr, Stefano Colombo & Henrik Jensen

Product details

  • No. of pages: 495
  • Language: English
  • Copyright: © William Andrew 2018
  • Published: October 12, 2018
  • Imprint: William Andrew
  • Paperback ISBN: 9780128126592
  • eBook ISBN: 9780128126608

About the Editors

Helder Santos

Hélder A. Santos is a Full Professor in Pharmaceutical Nanotechnology at the Faculty of Pharmacy of the University of Helsinki (Finland), Head of the Nanomedicines and Biomedical Engineering Lab, Director of the Doctoral Program in Drug Research, Director of FinPharmaNet in Finland, Chair of the Controlled Release Society Focus Group in Nanomedicine and Nanoscale Delivery, and Chairman and co-founder of Capsamedix Oy. Prof. Santos’ research is focused on nanobiomaterials, including nanoporous silica/silicon materials and polymeric-based nanoparticles for controlled drug delivery, diagnostics, and therapy. His research interests include the development of nanoparticles/nanomedicines for biomedical and healthcare applications. His current work builds a bridge between engineering, pharmaceutical, and medical research. He is the author/co-author of more than 330 publications, including reviews, journal editorials, book chapters, 4 edited books, and more than 260 conference proceedings/abstracts. He also holds 4 patents in the field.

Affiliations and Expertise

Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland; Helsinki Institute of Life Science (HiLIFE), University of Helsinki, Helsinki, Finland; Department of Biomedical Engineering, University Medical Center Groningen/University of Groningen, Groningen, The Netherlands

Dongfei Liu

Dongfei Liu is a Postdoctoral Fellow and PI at the Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland. He has developed a versatile and robust microfluidics platform to prepare extremely stable drug nanocrystals.

Affiliations and Expertise

Division of Pharmaceutical Chemistry and Technology, University of Helsinki, Finland

Hongbo Zhang

Hongbo Zhang is an Assistant Professor at Åbo Akademi, Finland. His research focuses on nanostructured materials prepared by microfluidics for drug delivery applications.

Affiliations and Expertise

Assistant Professor, Åbo Akademi, Finland

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