Micro- and Nanotechnology in Vaccine Development

Micro- and Nanotechnology in Vaccine Development

1st Edition - September 20, 2016

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  • Editors: Mariusz Skwarczynski, Istvan Toth
  • eBook ISBN: 9780323400299
  • Hardcover ISBN: 9780323399814

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This book provides a comprehensive overview of how use of micro- and nanotechnology (MNT) has allowed major new advance in vaccine development research, and the challenges that immunologists face in making further progress. MNT allows the creation of particles that exploit the inherent ability of the human immune system to recognize small particles such as viruses and toxins. In combination with minimal protective epitope design, this permits the creation of immunogenic particles that stimulate a response against the targeted pathogen. The finely tuned response of the human immune system to small particles makes it unsurprising that many of the lead adjuvants and vaccine delivery systems currently under investigation are based on nanoparticles.

Key Features

  • Provides a comprehensive and unparalleled overview of the role of micro- and nanotechnology in vaccine development
  • Allows researchers to quickly familiarize themselves with the broad spectrum of vaccines and how micro- and nanotechnologies are applied to their development
  • Includes a combination of overview chapters setting out general principles, and focused content dealing with specific vaccines, making it useful to readers from a variety of disciplines


Academic (researchers and grad students); Investigators in translational research; clinical scientists; pharmaceutical companies and development laboratories

Table of Contents

  • Overview of immune system.
    Innate immunity and special role of antigen presenting cells.
    Immunity and size.
    Introduction to the vaccines.
    Current challenges in vaccine development.
    Growing role of nanotechnology
    Nanotechnology in medical research
    Nanoparticle based peptide vaccines
    Liposome as nano- and microvaccines
    Lipid in peptide vaccine (excluding liposomes)
    Nanoadjuvants for peptide based vaccines
    Nanopatches for vaccine delivery
    Oral vaccine delivery
    Nano- and microtechnology in skin delivery of vaccines
    Nasal vaccine delivery
    Nanoparticles for cancer targeting vaccines by
    polymer based nanovaccines
    Lipidic microparticles for vaccine delivery
    Polymeric microparticles for vaccine delivery

Product details

  • No. of pages: 460
  • Language: English
  • Copyright: © Elsevier 2016
  • Published: September 20, 2016
  • Imprint: Elsevier
  • eBook ISBN: 9780323400299
  • Hardcover ISBN: 9780323399814

About the Editors

Mariusz Skwarczynski

Mariusz Skwarczynski completed his Ph.D. in Chemistry in 1999 at Wroclaw University of Technology. His postdoctoral training began at Tokushima Bunri University under the direction of Professor M. Nishizawa, where he studied the biomimetic total synthesis of anticancer agent paclitaxel. He then joined the laboratory of Professor Yoshiaki Kiso at Kyoto Pharmaceutical University to study prodrugs of paclitaxel. In 2004 he was awarded with prestigious Japanese fellowship (Japan Society for the Promotion of Science postdoctoral fellowship) and research grant to conduct further research on paclitaxel. He developed novel classes of paclitaxel prodrugs: isotaxoids and phototaxels. He also developed an epimerization-free method for the synthesis of novel building blocks (isodipeptides) for solid phase peptide synthesis and these units have been commercialized by Merck-Novabiochem. In 2008 he joined Professor Istvan Toth group at University of Queensland to work on drug, gene and vaccine delivery strategies. Since then he research is mainly focused on nanotechnology-based vaccine delivery approaches. He has published over 60 peer-reviewed publications, 4 book chapters, and other 100 conference abstracts. Currently he is Vice-Chancellor Fellow at University of Queensland.

Affiliations and Expertise

Vice-Chancellor and Fellow, University of Queensland, Australia

Istvan Toth

Professor Toth is a chemical engineer with a research focus on medicinal chemistry. He was awarded his PhD in 1972 and has since worked in Hungary, Canada and the United Kingdom before relocating to Australia in 1998. His major research interests are drug delivery, immunoadjuvants, synthetic vaccines and gene delivery. His research has attracted over $60 million in competitive grants, research contracts and investment funds in the past 10 years. He has over 300 peer-reviewed publications, 43 patents, and an excellent track record in research commercialization as a key founder of Alchemia (ASX listed), Implicit Bioscience Pty Ltd, Neurotide Pty Ltd and TetraQ (the commercial arm of Centre of Integrated Preclinical Drug Development).

Affiliations and Expertise

ARC Australian Professorial Fellow, Chair in Biological Chemistry, Professor of Pharmacy, Group Leader, IMB Division of Structural Biology

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