
Micro- and Nanoengineering of the Cell Surface
Description
Key Features
- Demystifies the direct engineering of cell surfaces, enabling materials scientists and chemists to manipulate or augment cell functions and phenotypes
- Provides a toolkit of micro- and nanoengineering approaches to the manipulation of the cell surface
- Unlocks the potential of cell surface manipulation for a range of new applications in the fields of in vitro research, cell therapy, tissue engineering, biosensing, and diagnostics
Readership
Scientists and engineers in the fields of Materials science / biomaterials, bionanotechnology / bioengineering / tissue engineering / sensing and imaging, chemistry, researchers and clinicians in the field of cell therapy and diagnostics, regenerative medicine, pharmaceutical R&D / drug delivery.
Table of Contents
- Foreword
- List of Contributors
- Chapter 1. Cell Membrane Biology and Juxtacrine Signal Conversion
- 1.1 Introduction
- 1.2 Cell Membrane Biology—Early Milestones
- 1.3 Membrane Microdomains
- 1.4 Cell Membrane Emergence
- 1.5 Juxtacrine Signaling and Rewiring Cellular Networks
- 1.6 Protein Painting, Artificial Veto Cell Engineering
- 1.7 Trans Signal Conversion
- 1.8 Redirecting Juxtacrine Signals
- 1.9 Creating Auto-Signaling Loops
- 1.10 SCP Therapeutic Flexibility
- 1.11 The Cell Membrane Frontier
- References
- Chapter 2. Cell Surface Engineering by Chemical Reaction and Remodeling
- 2.1 Introduction
- 2.2 Methods and Technology of Covalent Cell Surface Reaction
- 2.3 Relevance of Covalent Cell Surface Modification
- 2.4 Future Perspectives
- 2.5 Conclusions
- References
- Chapter 3. Bioconjugation Reactions in Living Cells: Development, Advances, and Applications of Glycan-Specific Technologies
- 3.1 Introduction
- 3.2 Bioorthogonal Chemical Ligation Reactions for Glycan Labeling
- 3.3 Bioorthogonal Ligation Reactions: Exploitation in MOE-Based Applications
- 3.4 Concluding Comments
- Acknowledgments
- References
- Chapter 4. Pushing the Bacterial Envelope: Strategies for Re-Engineering Bacterial Surfaces with Heterologous Proteins and Sugars
- 4.1 Bacterial Surface Display
- 4.2 Strategies for Re-Engineering Bacterial Surfaces with Heterologous Proteins
- 4.3 Applications of Bacteria Expressing Heterologous Surface Proteins
- 4.4 Strategies for Re-Engineering Bacterial Surfaces with Heterologous Sugars
- 4.5 Applications of Bacteria Expressing Heterologous Surface Sugars
- 4.6 Conclusion
- Acknowledgment
- References
- Chapter 5. Noncovalent Functionalization of Cell Surface
- 5.1 Introduction
- 5.2 Methods of Cell Surface Engineering—Applications and Recent Developments
- 5.3 Electrostatic Interactions Mediated Cell Surface Modification
- 5.4 Advantages and Limitations of the Noncovalent Modification of the Cell Surface
- 5.5 Conclusions and Future Perspectives
- Acknowledgments
- References
- Chapter 6. Lipid-Mediated Cell Surface Engineering
- 6.1 Introduction
- 6.2 One-Step Protein Transfer
- 6.3 Two-Step Protein Transfer
- 6.4 Summary
- Acknowledgments
- References
- Chapter 7. Engineering the Surface of Cells Using Biotin–Avidin Chemistry
- 7.1 Introduction: Rationale for Engineering the Cell Surface
- 7.2 Biotin and Avidin: An Overview
- 7.3 Methods for Engineering Cell Surfaces with Avidin–Biotin Complexes
- 7.4 Applications of Cell Surface Engineering Using Avidin–Biotin Chemistry
- 7.5 Conclusion
- References
- Chapter 8. Construction and Computation with Nucleic Acids on the Cell Surface
- 8.1 Computation of Cell Identity
- 8.2 Targeted Transport of a Payload to a Cell Surface and Activation of Innate Cellular Response
- 8.3 DNA Channels and Pores Spanning Lipid Membrane
- 8.4 Advances in Microscopy
- 8.5 Conclusion
- References
- Chapter 9. Cell Surface Enzymatic Engineering-Based Approaches to Improve Cellular Therapies
- 9.1 Introduction
- 9.2 Use of Enzymes to Modify Cell Surface Carbohydrates on Proteins and Lipids to Enhance Migration to Tissues
- 9.3 Modification of Enzyme Activity Leads to Changes on Cell Surface Structures that Deter Migration and Metastasis
- 9.4 Use of Enzymes to Improve the Therapeutic Function of Cells Through Modification of the Cell Surface
- 9.5 Conclusion
- References
- Chapter 10. Cell Microencapsulation for Tissue Engineering and Regenerative Medicine
- 10.1 Introduction
- 10.2 Encapsulation Requirements and Strategies
- 10.3 Materials Used for Cell Encapsulation
- 10.4 Therapeutic Applications of Encapsulated Cells
- 10.5 Challenges and Future Perspectives
- Acknowledgments
- References
- Chapter 11. Cell Engineering with Nanoparticles for Cell Imaging
- 11.1 Introduction
- 11.2 Imaging Modalities for NP Engineered Cells
- 11.3 Strategies for Cell Engineering with NPs
- 11.4 Challenges and Outlook
- 11.5 Conclusion
- Acknowledgments
- References
- Chapter 12. Micro/Nano-Engineering of Cells for Delivery of Therapeutics
- 12.1 Cell Therapy—Success and Current Challenges
- 12.2 Cell Surface Engineering to Improve Cell Targeting
- 12.3 Cell-Based Drug Delivery
- 12.4 Concluding Remarks
- References
- Chapter 13. Molecular Engineering of Cell and Tissue Surfaces with Polymer Thin Films
- 13.1 Introduction
- 13.2 General Design Principles and Considerations
- 13.3 Cell Surface Engineering with Polymer Thin Films
- 13.4 Biomedical Applications
- 13.5 Conclusion
- References
- Chapter 14. Biofunctionalization of Hydrogels for Engineering the Cellular Microenvironment
- 14.1 The 3D Extracellular Milieu
- 14.2 Mimicking the ECM
- 14.3 Engineering Degradability into Hydrogels
- 14.4 Hydrogel Nanoparticles
- 14.5 Conclusion
- List of Abbreviations
- References
- Chapter 15. Probe and Control of Cell–Cell Interactions Using Bioengineered Tools
- 15.1 Introduction
- 15.2 In Vitro Study of Cell–Cell Interactions Using Engineered Microdevices
- 15.3 Probing and Manipulation of Cell–Cell Interactions Using Engineered Molecular Tools
- 15.4 Conclusions and Perspectives
- References
- Index
Product details
- No. of pages: 400
- Language: English
- Copyright: © William Andrew 2014
- Published: May 30, 2014
- Imprint: William Andrew
- eBook ISBN: 9781455731558
- Hardcover ISBN: 9781455731466
About the Editors
Jeffrey Karp
Affiliations and Expertise
Weian Zhao
Affiliations and Expertise
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