Methods of Animal Experimentation

Methods of Animal Experimentation

Volume VI

1st Edition - September 28, 1981

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  • Editor: William I. Gay
  • eBook ISBN: 9781483259529

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Description

Methods of Animal Experimentation, Volume VI is a compendium of papers that defines which animals will prove most useful in biological experiments using the best methods in an environment of complex technologies and therapies. One paper reviews the genetic methods in animal experimentation including tests of Mendelian ratios, chromosomes crossing-over, chromosome anomalies, and gene transfer that produces congenic strains. Another paper explains the concepts and methodologies used in animals in ophthalmic research, particularly in ocular pharmacology, aqueous humor dynamics, glaucoma, and animal models of non-infectious uveitis. One paper analyzes the neural mechanisms of pain in an intact nervous system following ethical and moral principles of human treatment. For example, the use of different stimuli to elicit pain is applied only in situations where the stimuli is more appropriate, whether in behavioral or physiological experiments. The paper provides a list of requirements for the ideal pain stimulus. Another paper describes the methods in using standard animal models when an unknown agent is to be given as a general or local anesthesia. This book can prove beneficial to researchers, scientists, and laboratory technicians dealing with animals in relation to pharmacological, biological, chemical, and physiological research.

Table of Contents


  • List of Contributors

    Preface

    Contents of Previous Volumes

    Chapter 1 Genetic Methods in Animal Experimentation

    I. Genetic Methods

    II. Discovering Autosomal Traits

    III. Chromosomes: Behavior of One Pair in Meiosis

    IV. Discovering Sex-Linked Traits

    V. Tests of Mendelian Ratios

    VI. Complexities of Single-Locus Genetics

    VII. Assortment of Two Traits

    VIII. Chromosomes: Behavior of Two Pairs in Meiosis

    IX. Linkage of Two Traits

    X. Chromosomes: Crossing-Over

    XI. Recombination and Mapping

    XII. Tests for Allelism

    XIII. Concept of the Gene

    XIV. Mutations and Chromosome Anomalies

    XV. Complex Traits

    XVI. Random Breeding

    XVII. Phenotypic Selection

    XVIII. Inbreeding to Produce Inbred Strains and F1 Hybrids

    XIX. Recombinant Inbred Strains

    XX. Inbreeding to Produce Segregating Inbred Strains

    XXI. Gene Transfer to Produce Congenic Strains

    XXII. Nomenclature for Genes, Chromosome Anomalies, and Strains

    Bibliography

    References

    Chapter 2 Animals in Ophthalmic Research: Concepts and Methodologies

    I. Introduction

    II. Spontaneous Infectious Diseases

    III. Experimental Infectious Diseases

    IV. Ocular Pharmacology

    V. In Vitro Culture of Ocular Tissues

    VI. Animals in the Definition of Immunological Processes of the Eye

    VII. The Cornea

    VIII. The Sclera

    IX. Aqueous Humor Dynamics

    X. Glaucoma

    XI. Animal Models of Noninfectious Uveitis

    XII. The Lens and Experimental Cataract

    XIII. The Retina

    XIV. Optic Nerve

    XV. Ocular Circulation

    XVI. Experimental Ocular Oncology

    References

    Chapter 3 Laboratory Animals in Pain Research

    I. Introduction

    II. Definition of Pain and Analgesia

    III. Stimuli Used to Elicit Pain

    IV. Behavioral Assessment of Pain and Analgesia

    V. Anatomical Studies of Pain Pathways

    VI. Neurophysiology of Pain Pathways

    VII. Modulation of Pain

    References

    Chapter 4 Animal Models and Methods in Anesthesia Research

    I. Introduction

    II. General Anesthetics

    III. Local Anesthetics

    IV. Conclusions

    References

    Index

Product details

  • No. of pages: 380
  • Language: English
  • Copyright: © Academic Press 1981
  • Published: September 28, 1981
  • Imprint: Academic Press
  • eBook ISBN: 9781483259529

About the Editor

William I. Gay

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