Methods of Animal Experimentation - 1st Edition - ISBN: 9780122780066, 9781483259529

Methods of Animal Experimentation

1st Edition

Volume VI

Editors: William I. Gay
eBook ISBN: 9781483259529
Imprint: Academic Press
Published Date: 28th September 1981
Page Count: 380
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Description

Methods of Animal Experimentation, Volume VI is a compendium of papers that defines which animals will prove most useful in biological experiments using the best methods in an environment of complex technologies and therapies. One paper reviews the genetic methods in animal experimentation including tests of Mendelian ratios, chromosomes crossing-over, chromosome anomalies, and gene transfer that produces congenic strains. Another paper explains the concepts and methodologies used in animals in ophthalmic research, particularly in ocular pharmacology, aqueous humor dynamics, glaucoma, and animal models of non-infectious uveitis. One paper analyzes the neural mechanisms of pain in an intact nervous system following ethical and moral principles of human treatment. For example, the use of different stimuli to elicit pain is applied only in situations where the stimuli is more appropriate, whether in behavioral or physiological experiments. The paper provides a list of requirements for the ideal pain stimulus. Another paper describes the methods in using standard animal models when an unknown agent is to be given as a general or local anesthesia. This book can prove beneficial to researchers, scientists, and laboratory technicians dealing with animals in relation to pharmacological, biological, chemical, and physiological research.

Table of Contents


List of Contributors


Preface


Contents of Previous Volumes


Chapter 1 Genetic Methods in Animal Experimentation


I. Genetic Methods


II. Discovering Autosomal Traits


III. Chromosomes: Behavior of One Pair in Meiosis


IV. Discovering Sex-Linked Traits


V. Tests of Mendelian Ratios


VI. Complexities of Single-Locus Genetics


VII. Assortment of Two Traits


VIII. Chromosomes: Behavior of Two Pairs in Meiosis


IX. Linkage of Two Traits


X. Chromosomes: Crossing-Over


XI. Recombination and Mapping


XII. Tests for Allelism


XIII. Concept of the Gene


XIV. Mutations and Chromosome Anomalies


XV. Complex Traits


XVI. Random Breeding


XVII. Phenotypic Selection


XVIII. Inbreeding to Produce Inbred Strains and F1 Hybrids


XIX. Recombinant Inbred Strains


XX. Inbreeding to Produce Segregating Inbred Strains


XXI. Gene Transfer to Produce Congenic Strains


XXII. Nomenclature for Genes, Chromosome Anomalies, and Strains


Bibliography


References


Chapter 2 Animals in Ophthalmic Research: Concepts and Methodologies


I. Introduction


II. Spontaneous Infectious Diseases


III. Experimental Infectious Diseases


IV. Ocular Pharmacology


V. In Vitro Culture of Ocular Tissues


VI. Animals in the Definition of Immunological Processes of the Eye


VII. The Cornea


VIII. The Sclera


IX. Aqueous Humor Dynamics


X. Glaucoma


XI. Animal Models of Noninfectious Uveitis


XII. The Lens and Experimental Cataract


XIII. The Retina


XIV. Optic Nerve


XV. Ocular Circ

Details

No. of pages:
380
Language:
English
Copyright:
© Academic Press 1981
Published:
Imprint:
Academic Press
eBook ISBN:
9781483259529

About the Editor

William I. Gay

Ratings and Reviews