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Metabolomics and Microbiomics: Personalized Medicine from the Fetus to the Adult encompasses the most recent advances on the usage of metabolomics and microbiome research to improve disease diagnosis and healthcare. Medicine is changing from epidemiologic, descriptive, reductionist, and reactive approaches to individualized, predictive, and holistic ones by applying microbiomics to understand the functionality of the human body.
The book discusses topics such as systems biology approaches, omics technologies, perinatal programming, and personalized medicine. It also discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing. The book is a valuable resource for medical professionals and researchers in metabolomics, nutrition, microbiology, and personalized-predictive medicine. The book also will appeal to non-specialized professionals who may take advantage of its captivating and simple language.
- Covers the latest scientific discoveries in order to improve health and early diagnosis of diseases
- Brings a holistic and perinatal programming approach—from fetus to adulthood—to early and long-term prevention of diseases
- Provides illustrations and diagrams to facilitate understanding for readers
- Discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing
Members of medical professions, graduate students and researchers in metabolomics, nutrition, microbiology, and personalized-predictive medicine
- Author’s biography
- 1: Medicine centered on the person
- Through the patient’s eyes
- An irresistible evolution in medicine
- 2: The five great ideas of biology and medicine
- What is life?
- What are we talking about when we speak of the genome?
- The cell, the city of life
- Biochemistry: maximum yield, minimum cost
- Evolution: I change, ergo I survive
- Systems biology: the whole is not equal to the sum of its parts
- 3: The medicine of the future
- Medicine of the future, beyond all imagination
- DNA is not everything: not even identical twins are identical
- On the new farm… there’s a sheep, a cat, mice
- 4: The “-omics” technologies
- The new languages of medicine
- -Omics technologies
- Metabolomics: the rebirth of science or Harry Potter magic?
- Dogs, cats, and “electronic noses”
- Metabolomic Pindaric flights: the most important applications of metabolomics
- Evolution that becomes revolution: metabolomics as the generator of hypotheses
- What is at the root of metabolomics? An intriguing discovery
- Scale-free networks
- Network medicine
- Big data and… ten P medicine
- 5: Perinatal programming
- Are the fetus and the newborn the parents of the adult?
- The womb is more important than the home
- Return to the future: the placenta and perinatal programming
- The mysterious trees of life
- Journey to the center of the uterus: “I was born to replicate myself”
- Metabolic syndrome
- What do we need to know about perinatal planning? Ten golden rules
- Our plasticity is impressive
- Nutrition in pregnancy
- Transgenerational epigenetic inheritance
- Early nutrition and the destiny of the individual
- How we age depends on our fetal lives
- The mTOR protein: a two-faced angel
- Neonatomics and childomics
- 6: From birth to the miracle of mother’s milk
- Being born: an adrenaline-charged action movie
- Why does delivery begin?
- The first meal is like the first breath (a hymn to mother’s milk)
- The growth of the intestinal cells
- Microbiota of mother’s milk
- Metabolomics of mother’s milk and formula milk
- Multipotent stem cells of mother’s milk
- Mother’s milk with garlic or curry?
- Personalized fortification of milk of mothers who gave preterm birth
- 7: The fetus, the preterm baby, and the term baby: the good and the not so good
- The “weight” of prematures
- The new inhabitants of the planet Earth: adults who were born with extremely low weight
- Cerebral programming
- Epigenetic factors that influence development of the brain: alcohol, aluminum, prematurity
- Cardiac programming
- Kidney programming
- Neonatal ethics as a paradigm
- The wonderful and active world of the fetus
- The extraordinary world of sound of fetus and neonate
- 8: We are an ecosystem: in our bodies only one cell out of ten is human
- Brain versus gut: an ongoing war from the Pleistocene to the present
- The brain is a jungle, not a computer
- The brain–gut connection and microbiota: the gut’s revenge?
- The control room of our organism: the neuro-endo-immune supersystem
- Three different enterotypes
- How to change and monitor our enterotype
- Microbiomics and metabolomics
- 9: Microbiomics: from the clinic... to the chocolate
- From kefir to fecal transplant
- Kidney and microbiomics
- Autism spectrum disorders and microbiomics
- The strange case of the Caesarean section
- We are what we eat
- Bacteria that love chocolate and... Nobel laureates
- 10: Personalized medicine
- The medicine of complexity
- But is all this ethical?
- The hateful medical protocols
- Usain Bolt and the secret language of destiny
- The “treasure” of our nephrons
- 11: The new approaches of research
- How the course of research has changed
- Unexpected similarities
- Kidney regenerative medicine
- The new frontiers of research
- Gender medicine in perinatology
- Animals and the science of healing
- 12: The medical humanities
- The meeting between physician and patient
- Medical humanities: in the halfway land of complexity
- Narrative-based medicine
- 13: Scientific debate in the Internet age
- Between evidence-based medicine and medicine-based evidence
- Patients as Internauts
- 14: Messages to take home
- Author Index
- Subject Index
- No. of pages:
- © Academic Press 2016
- 25th August 2016
- Academic Press
- Paperback ISBN:
- eBook ISBN:
Vassilios Fanos, MD, is Postgraduate in Pediatrics, Neonatal Pathology and Intense Care, and Health Organization.
He is author of 20 books, 8 proceedings of congresses, and wrote 69 chapters for Italian and International publishing houses. He is guest editor of Curr Pharmac Design and Curr Med Chem. He has 336 scientific papers (Scopus, 303 on Pub Med). Dr. Fanos is editor-in-chief and founder of the Journal of Pediatric and Neonatal Individualized Medicine, board member of 10 journals (including J Chemother, World Journal of Obstetrics and Gynecology, Journal Maternal-Fetal Neonatal Medicine, World Journal of Clinical Pediatrics, Frontiers of Pathology, Frontiers in Neonatology, Journal of Urology & Research, Austin Journal of Pediatrics) and he is consultant referee of more than 40 international journals.
Dr. Fanos is investigator or co-investigator in research projects funded by public agencies (Veneto Region, Sardinia Region, University of Verona) or private agencies or pharmaceutical companies (Unicredit Bank, Fondazione Banco di Sardegna, Glaxo GSK, Marion Merrel Dow, Wellspring Corporation, Abbott, Danone, Byosinexus, Valeas) for a total of about 750.000 euros. Last grants: 198.000 euros from Italian Ministry of Health (first winner among 545 CMC projects) on metabolomics and sepsis. In 2013 he won a FP7 European Project with 6.000.000 euros on metabolomics and several grants ranging from 25.000 to 99.000 euros on metabolomics. His research focuses are Neonatology, nephrology, pharmacology, infections, laboratory medicine, and metabolomics
MD, Professor of Pediatrics, University of Cagliari, Italy
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