Metabolic Regulation

Metabolic Regulation

Metabolic Pathways

3rd Edition - January 1, 1971

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  • Editor: Henry J. Vogel
  • eBook ISBN: 9781483265544

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Metabolic Pathways, Third Edition, Volume V: Metabolic Regulation presents the regulation of metabolism in terms of the control of protein synthesis. This book discusses the significance of the control of metabolism in regard to the remarkable mechanisms involved and to the provision of an effective conceptual framework for appreciating the workings of the cell. Organized into 15 chapters, this edition begins with an overview of the numerous and diversified activities of a living cell. This text then examines the ability of living organisms to regulate the storage and mobilization of metabolizable energy. Other chapters consider the cytochrome system that represents the final common path of oxidation and coupled phosphorylation in the eukaryotic cell. This book discusses as well the profound changes that cell metabolism undergoes during differentiation. The final chapter deals with the chemical and genetic bases of the induction response in Gram-positive bacteria. This book is a valuable resource for biologists and physicians.

Table of Contents

  • List of Contributors


    Contents of Other Volumes

    Volumes in Series

    Chapter I Adenine Nucleotides as Stoichiometric Coupling Agents in Metabolism and as Regulatory Modifiers: The Adenylate Energy Charge

    I. Introduction

    II. Coupling Stoichiometries in Metabolism

    III. Regulation of Metabolism

    IV. Discussion

    V. Summary


    Chapter 2 Regulation of Fatty Acid Synthesis in Animal Tissues

    I. Introduction

    II. Generation of Extramitochondrial Acetyl-CoA and Reducing Equivalents

    III. Probable Control Sites

    IV. Regulation via Alteration in Enzyme Level

    V. Regulation via Metabolite Effectors


    Chapter 3 Regulation of Cytochrome Biosynthesis in Some Eukaryotes

    I. Introduction

    II. Lower Eukaryotes

    III. Higher Eukaryotes


    Chapter 4 δ-Aminolevulinic Acid Synthetase and the Control of Heme and Chlorophyll Synthesis

    I. Intermediates and Genes of the Heme-Chlorophyll-B12 Biosynthetic Chain

    II. ALA-Synthetase in Liver

    III. Induction of ALA-Synthetase by Chemicals, Drugs, and Steroids

    IV. Some Properties of the Inducing System of ALA-Synthetase in Liver

    V. Factors That Affect the Induction of ALA-Synthetase

    VI. Possbile Mechanisms for the Induction of ALA-Synthetase in Liver

    VII. ALA-Synthetase and Hemoglobin Synthesis

    VIII. Chlorophyll Synthesis and Its Controls

    IX. Summary


    Chapter 5 Transfer RNA and Regulation at the Translational Level

    I. Introduction

    II. Proposed Models for tRNA Function in Regulation

    III. Approaches to the Study of Changing tRNA Populations in Developing Systems

    IV. Evidence of tRNA and Aminoacyl-tRNA Modification

    V. Conclusions


    Chapter 6 Regulation of Gene Expression in Mammalian Cells

    I. Introduction

    II. The Eukaryotic Cell

    III. Genetic Information

    IV. Hormone Action

    V. A Model

    VI. The Role of the Steroid Hormone

    VII. Regulation of Gene Expression in Other Mammalian Systems

    VIII. Genetic Studies


    Chapter 7 Gene Clusters and the Regulation of Biosynthetic Pathways in Fungi

    I. Channeling

    II. Carbamyl Phosphate Regulation

    III. Tryptophan Synthetase

    IV. Arom Region

    V. Tryptophan Biosynthesis

    VI. Histidine Pathway

    VII. Conclusions


    Chapter 8 Regulation of Purine and Pyrimidine Metabolism

    I. Introduction

    II. Biosynthesis de Novo

    III. Interconversions

    IV. Exogenous Utilization


    Chapter 9 Regulation in the L-Arabinose System

    I. Introduction

    II. Mutant Isolation

    III. Mapping of Mutant Sites

    IV. The Enzymes and Structural Genes in the ara OIBAD Operon

    V. L-Arabinose Transport, Gene araE, and the Arabinose-Binding Protein

    VI. The Regulatory Gene araC and the Repressor ⇄ Activator Protein

    VII. Controlling Sites

    VIII. Dual-Effect Mutations in the Structural Genes of the L-Arabinose Operon OIBAD, Nonsense and Missense Mutations, and Self Catabolite Repression

    IX. Molecular Model for Regulation

    X. Alternative Models to Positive Control


    Chapter 10 Regulating the Lac Operon

    I. Introduction

    II. From Gene to Enzyme

    III. Catabolite Repression

    IV. Regulation of the Lac Operon


    Chapter 11 The Histidine Operon and Its Regulation

    I. Introduction

    II. The Enzymes

    III. The Operon

    IV. Repression Control

    V. Appendix: Bacterial Mutations


    Chapter 12 Regulation of Tryptophan Synthesis

    I. Introduction

    II. Historical Background

    III. Gene-Enzyme Relationships in the Tryptophan Biosynthetic Pathway

    IV. End-Product Inhibition Regulating Tryptophan Synthesis

    V. Regulation of Enzyme Synthesis

    VI. The Tryptophan Operon and Its Controlling Elements

    VII. Mode of Transcription, Translation, and Polarity

    VIII. The Metabolic Network


    Chapter 13 The Regulation of Enzyme Levels in the Pathways to the Branched-Chain Amino Acids

    I. Introduction

    II. The leu Gene Cluster and Its Expression

    III. The ilv Gene Cluster and Its Expression

    IV. Possible Models for Repression of the ilv and leu Gene Clusters


    Chapter 14 The Arginine Biosynthetic System and Its Regulation

    I. Introduction

    II. Arginine Biosynthetic System

    III. Models of Regulation

    IV. Mechanism of Repression in the Arginine System


    Chapter 15 The Regulation of Penicillinase Synthesis in Gram-Positive Bacteria

    I. Introduction

    II. Penicillin: Action and Reactions

    III. Inducible Penicillinase Synthesis in Gram-Positive Bacteria

    IV. Discussion


    Author Index

    Subject Index

Product details

  • No. of pages: 596
  • Language: English
  • Copyright: © Academic Press 1971
  • Published: January 1, 1971
  • Imprint: Academic Press
  • eBook ISBN: 9781483265544

About the Editor

Henry J. Vogel

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