Metabolic Inhibitors V3

Metabolic Inhibitors V3

A Comprehensive Treatise

1st Edition - January 1, 1972

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  • Editor: R Hochster
  • eBook ISBN: 9780323147156

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Description

Metabolic Inhibitors: A Comprehensive Treatise, Volume III reviews developments in metabolic and enzyme inhibition. With contributions by investigators experienced in their respective fields, the book explores metabolic processes or systems and covers topics ranging from membrane transport to immunization; gene activity; DNA, RNA, and protein syntheses; photosynthesis; lipid metabolism; and blood clotting. Organized into 12 chapters, this volume begins with an overview of transport reactions and their inhibition, emphasizing inhibitors of ATPase including cations, substrates, and products. Some chapters deal with inhibitors, such as antibiotics; polypeptide and protein hormones; modified transfer RNAs; and oligonucleotides. Other chapters discuss inhibitors of immune reactions; animal virus replication; plant viruses and mycoplasma; and isozymes. An account of genetic deletions is also given. Finally, the book considers molecules that act as repressors and derepressors of gene activity. This book will be beneficial to biochemists and medical research workers, as well as to virologists, microbiologists, plant physiologists, and agronomists.

Table of Contents


  • List of Contributors

    Preface

    Contents of Other Volumes

    Dedication

    Chapter 1 Inhibition of Transport Reactions

    A. Inhibitors of ATPase: NaK-ATPase and Related Enzymic Activities

    I. The Relationship of NaK-ATPase to Cation Transport

    II. Inhibitory Effects of Cations, Substrates, and Products

    III. Inhibitory Effects of CaCl2

    IV. Cardioactive Steroid Inhibitors

    V. Inhibitory Effects of Erythrophleum Alkaloids

    VI. Inhibitory Effects of Sulfhydryl Reagents

    VII. Effects of Oligomycin on NaK-ATPase and Related Enzymic Activities

    VIII. The Influence of Hydroxylamine on NaK-ATPase

    IX. Inhibition by Fluoride

    X. Inhibition by Diisopropylfluorophosphate

    XI. Inhibition by Berylium Ions

    XII. Effects of Neurotropic Agents Including Chlorinated Hydrocarbons

    XIII. Effects of Phlorizin, Phloretin, and Diethylstilbestrol

    XIV. Effects of Miscellaneous Agents

    References

    Chapter 2 Inhibition of Transport Reactions

    B. Sugars

    I. Introduction

    II. Classification of Sugar Transport Systems

    III. Sugar Transport Inhibitors

    References

    Chapter 3 Inhibition of Transport Reactions

    C. Control of Amino Acid Transfer

    I. Introduction

    II. Methods of Controlling Amino Acid Transfer

    III. Amino Acid Structure

    IV. Systems for Amino Acid Transfer

    V. Amino Acid Interactions

    VI. Sodium and Amino Acid Transfer

    VII. Potassium and Amino Acid Transfer

    VIII. Calcium and Amino Acid Transfer

    IX. Amino Acid Transfer and pH

    X. Effects of Other Changes in Environment

    XI. Relationship of Amino Acid Transfer to Other Solute Transfer Systems

    XII. Control of Amino Acid Accumulation

    XIII. Influence of Hormones on Amino Acid Transfer

    XIV. Energy Considerations

    XV. Amino Acid Transfer and Genetics

    References

    Chapter 4 Inhibitors of Immune Reactions

    I. Introduction

    II. Immunosuppressants

    III. Variables That Determine the Success of an Immunosuppresive Regimen

    IV. Immunosuppressive Mechanisms

    V. Human Applications

    References

    Chapter 5 Repressors and Derepressors of Gene Activity

    I. Introduction

    II. Prokaryote Transcription

    III. RNA Polymerase Control Factors

    IV. Eukaryote Transcription

    V. Gene Replication

    VI. Summary

    References

    Chapter 6 Inhibitors of RNA and DNA Biosynthesis

    I. Introduction

    II. Inhibitors of RNA Synthesis

    III. Inhibitors of DNA Synthesis

    IV. Inhibitors of Both RNA and DNA Synthesis

    V. RNA-Dependent DNA Synthesis

    References

    Chapter 7 Genetic Deletions

    I. Introduction

    II. Selection and Detection of Mutants Bearing Potential Deletions

    III. Operational Criteria for Establishing a Mutation as a Deletion

    VI. The Frequency, Topography, and Topology of Deletion Mutations

    V. Enzymes That Cut and Repair DNA

    VI. Agents That May Promote Deletions

    VII. Hypothetical Mechanisms

    VIII. Conclusions

    References

    Chapter 8 Inhibitors of Animal Virus Replication

    I. Introduction

    II. Compounds Affecting the Early Steps of Virus Replication

    III. Compounds Affecting the Late Steps of Virus Replication

    IV. Inhibitors of Virus-Specific RNA Synthesis

    V. Inhibitors of Virus Protein Synthesis: Cycloheximide, Streptovitacin A, and Puromycin

    VI. Inhibitors of Viral DNA Synthesis

    References

    Chapter 9 Inhibitors of Plant Viruses and Mycoplasma

    I. Introduction

    II. Substances That Interfere with Establishment of Virus Infection

    III. Inhibitors of Virus Increase

    IV. Effect of Tetracyclines on Plant-Pathogenic Mycoplasmas

    References

    Chapter 10 Novel Antibiotics as Metabolic Inhibitors

    I. Introduction

    II. Inhibitors of Cell Wall Synthesis

    III. Interaction of Antibiotics with Lipid Membranes

    IV. Inhibitors of the Respiratory Chain and Energy Transfer

    V. Inhibitors of DNA Replication and Transcription

    VI. Antibiotic Inhibitors of Protein Synthesis

    VII. A Potpourri of Antibiotics

    VIII. Chemical Structure and Biological Activity of Antibiotics

    IX. The Origin and Function of Antibiotics

    References

    Chapter 11 Polypeptide and Protein Hormones as Inhibitors

    I. Introduction

    II. Structure and Mode of Action of Protein and Polypeptide Hormones

    III. Hormones That Act as Inhibitors

    IV. Hormone Analogs as Inhibitors

    V. Conclusion

    References

    Chapter 12 Inhibition of Isozymes

    I. Introduction

    II. Metabolic Significance of Isozymes and the Role of Inhibitors in Their Study

    III. The Role of Inhibitors in Elucidating the Molecular Mechanisms Responsible for the Generation of Isozymes

    IV. Inhibition of LDH Isozymes

    V. Conclusions

    References

    Author Index

    Subject Index




Product details

  • No. of pages: 526
  • Language: English
  • Copyright: © Academic Press 1972
  • Published: January 1, 1972
  • Imprint: Academic Press
  • eBook ISBN: 9780323147156

About the Editor

R Hochster

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