Metabolic Conjugation and Metabolic Hydrolysis

Metabolic Conjugation and Metabolic Hydrolysis

Volume I

1st Edition - January 1, 1970

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  • Editor: William H. Fishman
  • eBook ISBN: 9781483270272

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Metabolic Conjugation and Metabolic Hydrolysis, Volume I is a comprehensive account of the main conjugation mechanisms and hydrolytic reactions. Topics covered range from the metabolic conjugates of steroids and N-hydroxy compounds to the effects of conjugated steroids on enzymes. The glucuronic acid pathway is also discussed, along with sulfoconjugation and sulfohydrolysis. Comprised of eight chapters, this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations. The isolation, recognition, enzymic formation and hydrolysis, and the possible significance of steroid N-acetylglucosaminides and glucosides are considered. The book also examines the mechanisms involved in the enzymic formation of N-hydroxy compounds; the pathways by which N-hydroxy compounds may be further metabolized in vivo; and the chemical properties of conjugates of N-hydroxy compounds, particularly as these properties are related to the generation of reactive cations or free radicals in vivo. The possible role of conjugates of N-hydroxy compounds in the mechanism of carcinogenesis by aromatic amines and their N-acyl derivatives is also analyzed. Finally, glycoprotein and mucopolysaccharide hydrolysis and the role of hydrolases in cellular death are described. This monograph will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.

Table of Contents

  • List of Contributors


    History of the Discovery of the Conjugation Mechanisms

    I. Introduction

    II. Glycoside Conjugations

    III. Amino Acid Conjugations

    IV. Other Conjugations


    New Metabolic Conjugates of Steroids

    I. Introduction

    II. Conjugation with N-Acetylglucosamine

    III. Conjugation with Glucose

    IV. Conjugations Other Than Glycoside or Sulfate

    V. Conjugation with Glucuronic Acid

    VI. Conjugation with Sulfuric Acid

    VII. Miscellaneous Steroid Conjugates or Complexes

    VIII. Conclusion


    Conjugates of N-Hydroxy Compounds

    I. Introduction

    II. Biochemical Formation of N-Hydroxy Compounds

    III. Glucuronide Conjugates of N-Hydroxy Compounds

    IV. Ν- and O-Sulfonate Conjugates of N-Hydroxy Compounds

    V. Other Conjugates of N-Hydroxy Compounds

    VI. O-Conjugates of N-Hydroxy Compounds as Ultimate Carcinogenic Metabolites of Aromatic Amines


    Effects of Conjugated Steroids on Enzymes

    I. Introduction

    II. Interaction of Conjugated Steroids with Enzymes

    III. Effects of Steroid Conjugates on Nonenzymic Proteins

    IV. Effects of Conjugated Steroids on "in Vivo" Functions

    V. Effects of Anionic Ligands on Protein Structure

    VI. Biological Relevance

    VII. Summary


    Glucuronic Acid Pathway

    I. Introduction

    II. Biosynthesis of Glucuronides

    III. Biosynthesis of Free Glucuronic Acid

    IV. Further Metabolism of Free Glucuronic Acid

    V. Regulation of the Glucuronic Acid Pathway by Nucleotides and Substrates

    VI. Urinary Metabolites of the Glucuronate Pathway Related to Enzyme Activities of Various Organs

    VII. Clinical Conditions


    Sulfoconjugation and Sulfohydrolysis

    I. Introduction

    II. Conjugates with P-O-SO3- Linkages

    III. Conjugates with C-O-SO3- Linkages

    IV. Conjugates with N-SO3- Linkages

    V. General Comment


    Glycoprotein and Mucopolysaccharide Hydrolysis (Glycoprotein and Mucopolysaccharide Hydrolysis in the Cell)

    I. Introduction

    II. Substrates

    III. Enzymes

    IV. Unsolved Problems


    Hydrolases and Cellular Death

    I. Introduction

    II. The Development of Lysosomal Hypothesis

    III. Hydrolase Activity and Cell Death

    IV. Autodigestion

    V. The Role of Hydrolases in Cell Death and Turnover

    VI. Conclusion


    Author Index

    Subject Index

Product details

  • No. of pages: 508
  • Language: English
  • Copyright: © Academic Press 1970
  • Published: January 1, 1970
  • Imprint: Academic Press
  • eBook ISBN: 9781483270272

About the Editor

William H. Fishman

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