Metabolic Conjugation and Metabolic Hydrolysis - 1st Edition - ISBN: 9780122576010, 9781483270272

Metabolic Conjugation and Metabolic Hydrolysis

1st Edition

Volume I

Editors: William H. Fishman
eBook ISBN: 9781483270272
Imprint: Academic Press
Published Date: 1st January 1970
Page Count: 508
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Description

Metabolic Conjugation and Metabolic Hydrolysis, Volume I is a comprehensive account of the main conjugation mechanisms and hydrolytic reactions. Topics covered range from the metabolic conjugates of steroids and N-hydroxy compounds to the effects of conjugated steroids on enzymes. The glucuronic acid pathway is also discussed, along with sulfoconjugation and sulfohydrolysis.

Comprised of eight chapters, this volume first looks at the history of conjugation mechanisms before proceeding to developments in metabolic conjugations. The isolation, recognition, enzymic formation and hydrolysis, and the possible significance of steroid N-acetylglucosaminides and glucosides are considered. The book also examines the mechanisms involved in the enzymic formation of N-hydroxy compounds; the pathways by which N-hydroxy compounds may be further metabolized in vivo; and the chemical properties of conjugates of N-hydroxy compounds, particularly as these properties are related to the generation of reactive cations or free radicals in vivo. The possible role of conjugates of N-hydroxy compounds in the mechanism of carcinogenesis by aromatic amines and their N-acyl derivatives is also analyzed. Finally, glycoprotein and mucopolysaccharide hydrolysis and the role of hydrolases in cellular death are described.

This monograph will be a useful resource for biologists, biochemists, physiologists, and pharmacologists.

Table of Contents


List of Contributors


Preface


History of the Discovery of the Conjugation Mechanisms


I. Introduction


II. Glycoside Conjugations


III. Amino Acid Conjugations


IV. Other Conjugations


References


New Metabolic Conjugates of Steroids


I. Introduction


II. Conjugation with N-Acetylglucosamine


III. Conjugation with Glucose


IV. Conjugations Other Than Glycoside or Sulfate


V. Conjugation with Glucuronic Acid


VI. Conjugation with Sulfuric Acid


VII. Miscellaneous Steroid Conjugates or Complexes


VIII. Conclusion


References


Conjugates of N-Hydroxy Compounds


I. Introduction


II. Biochemical Formation of N-Hydroxy Compounds


III. Glucuronide Conjugates of N-Hydroxy Compounds


IV. Ν- and O-Sulfonate Conjugates of N-Hydroxy Compounds


V. Other Conjugates of N-Hydroxy Compounds


VI. O-Conjugates of N-Hydroxy Compounds as Ultimate Carcinogenic Metabolites of Aromatic Amines


References


Effects of Conjugated Steroids on Enzymes


I. Introduction


II. Interaction of Conjugated Steroids with Enzymes


III. Effects of Steroid Conjugates on Nonenzymic Proteins


IV. Effects of Conjugated Steroids on "in Vivo" Functions


V. Effects of Anionic Ligands on Protein Structure


VI. Biological Relevance


VII. Summary


References


Glucuronic Acid Pathway


I. Introduction


II. Biosynthesis of Glucuronides


III. Biosynthesis of Free Glucuronic Acid


IV. Further Metabolism of Free Glucuronic Acid


V. Regulation of the Glucuronic Acid Pathway by Nucleotides and Substrates


VI. Urinary Metabo

Details

No. of pages:
508
Language:
English
Copyright:
© Academic Press 1970
Published:
Imprint:
Academic Press
eBook ISBN:
9781483270272

About the Editor

William H. Fishman

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