Research has shown that the lung is capable of metabolically activating xenobiotics into intermediates that can covalently bind to pulmonary tissue. Further, it has been shown that the lung consists of many distinct cell types with the ability to take up and sequester metabolically unchanged drugs and chemicals that are ultimately toxic in effect. This volume reflects the extent of these developments and provides a state-of-the art reference in a rapidly evolving field incorporating both drug metabolism and pulmonary toxicology research.
For researchers in pharmacology, toxicology, environmental sciences and pulmonary medicine.
- © Pergamon 1993
- 12th March 1993
- eBook ISBN:
- Hardcover ISBN:
@from:D.H. Hutson @qu:...an excellent source for the state-of-the-knowledge regarding the role of the lung in generating reactive metabolites that are responsible for site-specific toxicity...this book represents an excellent compilation of recent review articles related to the field of pulmonary toxicity and the role of lung metabolism in inducing toxicity of materials entering through the lungs as well as via the systematic circulation. @source:International Society for the Study of Xenobiotics Newsletter
National Cancer Institute, Division of Cancer Treatment, Bethesda, MD, USA