Mems for Biomedical Applications

Mems for Biomedical Applications

1st Edition - July 18, 2012

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  • Editors: Shekhar Bhansali, Abhay Vasudev
  • eBook ISBN: 9780857096272

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The application of Micro Electro Mechanical Systems (MEMS) in the biomedical field is leading to a new generation of medical devices. MEMS for biomedical applications reviews the wealth of recent research on fabrication technologies and applications of this exciting technology.The book is divided into four parts: Part one introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms. Part two describes applications of MEMS for biomedical sensing and diagnostic applications. MEMS for in vivo sensing and electrical impedance spectroscopy are investigated, along with ultrasonic transducers, and lab-on-chip devices. MEMS for tissue engineering and clinical applications are the focus of part three, which considers cell culture and tissue scaffolding devices, BioMEMS for drug delivery and minimally invasive medical procedures. Finally, part four reviews emerging biomedical applications of MEMS, from implantable neuroprobes and ocular implants to cellular microinjection and hybrid MEMS.With its distinguished editors and international team of expert contributors, MEMS for biomedical applications provides an authoritative review for scientists and manufacturers involved in the design and development of medical devices as well as clinicians using this important technology.

Key Features

  • Reviews the wealth of recent research on fabrication technologies and applications of Micro Electro Mechanical Systems (MEMS) in the biomedical field
  • Introduces the fundamentals of MEMS for biomedical applications, exploring the microfabrication of polymers and reviewing sensor and actuator mechanisms
  • Considers MEMS for biomedical sensing and diagnostic applications, along with MEMS for in vivo sensing and electrical impedance spectroscopy


Researchers, materials scientists and medical device manufacturers; students and clinicians of medical engineering

Table of Contents

  • Contributor contact details

    Woodhead Publishing Series in Biomaterials


    Chapter 1: Microfabrication of polymers for bioMEMS


    1.1 Introduction

    1.2 Microfabrication

    1.3 Polymers and processes

    1.4 Conclusions

    Chapter 2: Review of sensor and actuator mechanisms for bioMEMS


    2.1 Introduction: transducers

    2.2 Sensors

    2.3 Actuators

    2.4 Biomedical applications of sensors and actuators

    2.5 Optical biosensor

    2.6 Microrobotics in biomedical applications

    2.7 Conclusion

    Chapter 3: MEMS for in vivo sensing


    3.1 Introduction

    3.2 Overview of MEMS in vivo devices and sensors

    3.3 Challenges and possible solutions to in vivo sensing methodology

    3.4 Regulatory dimensions

    3.5 Conclusions and future trends

    Chapter 4: MEMS and electrical impedance spectroscopy (EIS) for non-invasive measurement of cells


    4.1 Importance of MEMS in cellular assays

    4.2 Impedimetric measurement theory

    4.3 Visualization and modeling

    4.4 Bioimpedance before MEMS: patch clamp measurements

    4.5 MEMS in bioimpedance applications

    4.6 Future trends

    4.7 Sources of further information and advice

    Chapter 5: MEMS ultrasonic transducers for biomedical applications


    5.1 Introduction

    5.2 Modeling and design of capacitive micromachined ultrasonic transducers (CMUTs)

    5.3 Fabrication

    5.4 Integration

    5.5 Biomedical applications

    5.6 Conclusion and future trends

    Chapter 6: Lab-on-chip (LOC) devices and microfluidics for biomedical applications


    6.1 Introduction

    6.2 Pressure-driven lab-on-chip (LOC)

    6.3 Capillary-driven LOC

    6.4 Electrokinetic-driven LOC

    6.5 Centrifugal-driven LOC

    6.6 Droplet-based LOC

    6.7 Electrowetting-based LOC

    6.8 Future trends

    Chapter 7: Fabrication of cell culture microdevices for tissue engineering applications


    7.1 Introduction: cell culture microdevices

    7.2 Motivation for microdevice development

    7.3 Design and fabrication concepts for cell culture

    7.4 Applications of cell culture microdevices

    7.5 Future trends

    7.6 Sources of further information and advice

    Chapter 8: MEMS manufacturing techniques for tissue scaffolding devices


    8.1 Introduction

    8.2 Tissue scaffold design

    8.3 Tissue scaffold fabrication using MEMS approaches

    8.4 Applications of MEMS-fabricated tissue scaffold

    8.5 Conclusion

    Chapter 9: BioMEMs for drug delivery applications


    9.1 Introduction

    9.2 Transdermal delivery

    9.3 Implantable systems

    9.4 Microfabricated drug delivery vehicles

    9.5 Conclusions

    9.6 Acknowledgement

    Chapter 10: Applications of MEMS technologies for minimally invasive medical procedures


    10.1 Introduction

    10.2 Microvisualization

    10.3 Micromanipulation

    10.4 Future trends and conclusions

    Chapter 11: Smart microgrippers for bioMEMS applications


    11.1 Introduction

    11.2 Microgripping and release strategies

    11.3 Microgripper demonstration: microcage

    11.4 Conclusions

    11.5 Acknowledgement

    Chapter 12: Microfluidic techniques for the detection, manipulation and isolation of rare cells


    12.1 Introduction

    12.2 Size-based isolation

    12.3 Mass-based isolation

    12.4 Electrical-based isolation

    Chapter 13: MEMS as implantable neuroprobes


    13.1 Introduction – neuronal communication

    13.2 MEMS-based neuronal intervention devices

    13.3 Tissue response against implanted neural microelectrode interfaces

    13.4 Implantable wireless recording integrated circuit (IC) challenges

    Chapter 14: MEMS as ocular implants


    14.1 Introduction

    14.2 Implantable MEMS for glaucoma therapy

    14.3 Integrated microsystems for artificial retinal implants

    14.4 Future trends

    14.5 Conclusion

    Chapter 15: Cellular microinjection for therapeutic and research applications


    15.1 Introduction

    15.2 Significance of cellular injection

    15.3 Microinjection

    15.4 MEMS technologies for microinjection

    15.5 Future of mechanical microinjection

    15.6 Automating microinjection

    15.7 Conclusion

    Chapter 16: Hybrid MEMS: Integrating inorganic structures into live organisms


    16.1 Introduction

    16.2 Hybrid integration

    16.3 Vacuum microfabrication on Drosophila

    16.4 Conclusions and future trends


Product details

  • No. of pages: 512
  • Language: English
  • Copyright: © Woodhead Publishing 2012
  • Published: July 18, 2012
  • Imprint: Woodhead Publishing
  • eBook ISBN: 9780857096272

About the Editors

Shekhar Bhansali

Shekhar Bhansali is the Alcatel-Lucent Professor and the Chair of the Department of Electrical and Computer Engineering at Florida International University, USA.

Abhay Vasudev

Abhay Vasudev is a Graduate Researcher at Florida International University’s bioMEMS and Microsystems Lab.

Affiliations and Expertise

Florida International University, USA

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