Medicinal Chemistry

Medicinal Chemistry

First published on February 10, 2020

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  • Editors: Rudi van Eldik, Peter Sadler
  • Hardcover ISBN: 9780128191965
  • eBook ISBN: 9780128191972

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Description

Medicinal Chemistry, Volume 75, the latest release in the Advances in Inorganic Chemistry series, presents timely and informative summaries on current progress in a variety of subject areas. This acclaimed serial features reviews written by experts in the field, serving as an indispensable reference to advanced researchers that empowers readers to pursue new developments in each field. Users will find this to be a comprehensive overview of recent findings and trends from the last decade that covers various kinds of inorganic topics, from theoretical oriented supramolecular chemistry, to the quest for accurate calculations of spin states in transition metals.

Key Features

  • Provides the authority and expertise of leading contributors from an international board of authors
  • Presents the latest release in the Advances in Inorganic Chemistry series
  • Includes the latest information on medicinal chemistry

Readership

Chemists interested in classical inorganic chemistry, computational chemists interested in the application of their methods to various kinds of applied inorganic chemistry

Table of Contents

  • 1. 150 Years of the periodic table: New medicines and diagnostic agents
    Cinzia Imberti and Peter J. Sadler
    2. Medicinal inorganic chemistry: New perspectives and targets for the periodic table
    Nicholas P. Farrell
    3. Anti-cancer gold, platinum and iridium compounds with porphyrin and/or N-heterocyclic carbene ligand(s)
    Ka-Chung Tong, Di Hu, Pui-Ki Wan, Chun-Nam Lok and Chi-Ming Che
    4. Metal N-heterocyclic carbene complexes in medicinal chemistry
    Ingo Ott
    5. Rational design of anticancer platinum(IV) prodrugs
    Shuren Zhang, Xiaoyong Wang and Zijian Guo
    6. Bismuth drugs as antimicrobial agents
    Runming Wang, Hongyan Li, Tiffany Ka-Yan Ip and Hongzhe Sun
    7. Antimony and bismuth as antimicrobial agents
    Rebekah N. Duffin, Melissa V. Werrett and Philip C. Andrews
    8. Pharmacophore conjugation strategy for multi-targeting metal-based anticancer complexes
    Yao Zhao, Yan Kang, Fengmin Xu, Wei Zheng, Qun Luo, Yanyan Zhang, Feifei Jia and
    Fuyi Wang
    9. Organelle-targeting metal anticancer agents
    Lina Xie, Ruilin Guan, Thomas W. Rees and Hui Chao
    10. From the hypothesis-driven development of organometallic anticancer drugs to new methods in mode of action studies
    Muhammad Hanif and Christian G. Hartinger
    11. Design and applications of catalytic metallodrugs containing the ATCUN motif
    Zhen Yu and James A. Cowan
    12. The eyes have it: Using X-ray crystallography to determine the binding modes of medically relevant ruthenium/DNA complexes
    Kane Thomas McQuaid and Christine Janet Cardin
    13. Interaction of metal complexes with G-quadruplex DNA
    Ramon Vilar
    14. CXCR4-targeted metal complexes for molecular imaging
    Isaline Renard and Stephen J. Archibald

Product details

  • No. of pages: 510
  • Language: English
  • Copyright: © Academic Press 2020
  • Published: February 10, 2020
  • Imprint: Academic Press
  • Hardcover ISBN: 9780128191965
  • eBook ISBN: 9780128191972

About the Serial Volume Editors

Rudi van Eldik

Rudi van Eldik

Rudi van Eldik was born in Amsterdam (The Netherlands) in 1945 and grew up in Johannesburg (South Africa). He received his chemistry education and DSc degree at the former Potchefstroom University (SA), followed by post-doctoral work at the State University of New York at Buffalo (USA) and the University of Frankfurt (Germany). After completing his Habilitation in Physical Chemistry at the University of Frankfurt in 1982, he was appointed as Professor of Inorganic Chemistry at the Private University of Witten/Herdecke in 1987. In 1994 he became Professor of Inorganic and Analytical Chemistry at the University of Erlangen-Nürnberg, from where he retired in 2010. At present he is Professor of Inorganic Chemistry at the Jagiellonian University in Krakow, Poland, and Visiting Professor of Inorganic Chemistry at the N. Copernicus University in Torun, Poland.

His research interests cover the elucidation of inorganic and bioinorganic reaction mechanisms, with special emphasis on the application of high pressure thermodynamic and kinetic techniques. In recent years his research team also focused on the application of low-temperature rapid-scan techniques to identify and study reactive intermediates in catalytic cycles, and on mechanistic studies in ionic liquids. He is Editor of the series Advances in Inorganic Chemistry since 2003. He serves on the Editorial Boards of several chemistry journals. He is the author of over 880 research papers and review articles in international journals and supervised 80 PhD students. He has received honorary doctoral degrees from the former Potchefstroom University, SA (1997), Kragujevac University, Serbia (2006), Jagiellonian University, Krakow, Poland (2010), University of Pretoria, SA (2010), and Ivanovo State University of Chemistry and Technology, Russia (2012). He has developed a promotion activity for chemistry and related experimental sciences in the form of chemistry edutainment presentations during the period 1995-2010. In 2009 he was awarded the Federal Cross of Merit (‘Bundesverdienstkreuz’) by the Federal President of Germany, and the Inorganic Mechanisms Award by the Royal Society of Chemistry (London).

His hobbies include music, hiking, jogging, cycling and motor-biking. He is the father of two and grandfather of four children.

Affiliations and Expertise

University of Erlangen-Nurnberg, Germany; Professor of Inorganic Chemistry at the Jagiellonian University in Krakow, Poland

Peter Sadler

Peter Sadler, is at Warwick University, UK

Affiliations and Expertise

Warwick University, UK

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