Medicinal Chemistry of Chemotherapeutic Agents

Medicinal Chemistry of Chemotherapeutic Agents

A Comprehensive Resource of Anti-infective and Anti-cancer Drugs

1st Edition - December 1, 2022

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  • Editors: Pratap Acharya, Michio Kurosu
  • Paperback ISBN: 9780323905756

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Medicinal Chemistry of Chemotherapeutic Agents: A Comprehensive Resource of Anti-infective and Anti-cancer Drugs focuses on the basics and fundamentals of chemistry involved in chemotherapeutic agents. Each chapter comprises distinct chemical classifications that include structure and IUPAC nomenclature, synthetic schemes and routes for each drug, mechanism of the drug action, metabolic pathway and structure–activity relationship (SAR) studies. The book covers current research focused on drug resistance and methods to overcome it, the development of newer drugs belonging to each category of the chemotherapeutic agents, molecules currently under clinical trials, and newly approved drugs, if any. This book will be a valuable resource for academics and researchers, helping them to understand the fundamentals of the medicinal chemistry of the chemotherapeutic agents.

Key Features

  • Includes current research focused on drug resistance and methods to overcome problems
  • Outlines synthetic schemes and metabolic pathways of chemotherapeutic agents
  • Discusses molecules under clinical trials and newly approved drugs


Pharmaceutical and medicinal chemists working in the pharmaceutical industry and academia

Table of Contents

  • 1. Introduction to Chemotherapy: General and Clinical Considerations

    Unit I Antibacterial Agents
    2. Sulfonamides, Quinolones, Antiseptics and Disinfectants
    Unit II Antibacterial Antibiotics
    3. Beta-Lactam Antibiotics: Penicillins, Cephalosporins, Monobactams, Carbapenems and Beta-lactamase Inhibitors
    4. Tetracyclines and Chloramphenicol
    5. Aminoglycoside Antibiotics
    6. Macrolide, Lincosamide, Glycopeptide and Other Antibacterial Antibiotics
    Unit III Antimycobacterial Agents
    7. Antitubercular Drugs
    8. Antileprotic Drugs
    Unit IV Antifungal Agents
    9. Topical and Systemic Antifungal Drugs
    Unit V Antiviral Agents
    10. Antiviral Drugs and Vaccines
    Unit VI Antiprotozoal Agents
    11. Antimalarial Drugs
    12. Antiamoebic Drugs
    13. Drugs for Giardiasis, Trichomoniasis and Leishmaniasis
    UNIT VII Anthelmintics
    14. Vermifuge and Vermicide Drugs

    15. Synthetic Cytotoxic Drugs as Cancer Chemotherapeutic Agents
    16. Naturally Occurring Anticancer Cytotoxic Drugs
    17. Hormones and Antihormones in Cancer Chemotherapy
    18. Biologicals and Small Molecules as Target Specific Cancer Chemotherapeutic Agents

Product details

  • No. of pages: 700
  • Language: English
  • Copyright: © Academic Press 2023
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780323905756

About the Editors

Pratap Acharya

Dr Pratap Chandra Acharya is presently working as Assistant Professor of Pharmaceutical Chemistry at the Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura (W) India. He received his PhD in Pharmaceutical Chemistry from Panjab University, Chandigarh and M.Pharm (Pharmaceutical Chemistry) from IIT (BHU), Varanasi, India. He has more than 10 years of teaching and research experience in the field of pharmaceutical chemistry. He has been the member of various learned academic bodies such as IUPAC and APTI and has served as a reviewer to several international journals. His current research work involves various drug discovery projects for the development of anticancer drug candidates especially for colon cancer.

Affiliations and Expertise

Assistant Professor, Pharmaceutical Chemistry at the Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura (W), India

Michio Kurosu

Michio Kurosu has completed his Ph.D. from Osaka University, Japan and postdoctoral studies from Harvard University, Chemistry and Chemical Biology. He is a Professor of Pharmaceutical Science at University of Tennessee Health Science Center (UTHSC), USA. He has been teaching medicinal chemistry courses for pharmacy and Ph. D. students at UTHSC. He has a long-term interest in identifying new drug targets for bacterial infections and cancer chemotherapeutics. His research includes antibacterial and anticancer drug discoveries associated with Gram-negative bacteria, Mycobacterium spp., spore-forming bacteria (e.g. Clostridioides difficile), and solid cancers (e.g., pancreatic, breast, and ovarian cancers). As principal investigator on several NIH- and internally-funded programs, he has studied essential enzymes for growth of Acinetobacter baumannii, Klebsiella pneumoniae, and Mycobacterium tuberculosis, and glycosyl transferases for pancreatic and cervical cancers. He has been serving as editorial board members of several international journals and scientific reviewers of the NIH study sections.

Affiliations and Expertise

Professor, Pharmaceutical Science, University of Tennessee Health Science Center (UTHSC), USA

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