Medicinal Chemistry Advances - 1st Edition - ISBN: 9780080252971, 9781483158211

Medicinal Chemistry Advances

1st Edition

Proceedings of the Seventh International Symposium on Medicinal Chemistry, Torremolinos, Spain 2 - 5 September 1980

Editors: Federico G. De Las Heras Salvador Vega
eBook ISBN: 9781483158211
Imprint: Pergamon
Published Date: 1st January 1981
Page Count: 526
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Description

Medicinal Chemistry Advances covers the proceedings of the Seventh International Symposium on Medicinal Chemistry. The book reviews the papers presented in the symposium. The main topics that this book covers are nucleosides in chemotherapy; theoretical approaches to medicinal chemistry; platelets and antithrombotic agents; receptors; antiviral agents; antilipidemic agents; respiratory system; central nervous system; enzyme inhibitors; and bioactive peptides. Chemists, pharmacologists, biochemists, physicians and other professionals and researchers concerned with the development of pharmaceutical field will find this book interesting.

Table of Contents


List of Contributors

Introduction

Plenary Lectures

Current Options in Drug Design

Medicinal Chemistry and Current Problems in Drug Development

Symposia Lectures

2'-Fluoro-arabinosyl Pyrimidine Nucleosides: Chemistry, Antiviral and Potential Anticancer Activities

Nucleoside Antibiotics: Mode of Action

Antitumor and Antiviral Activity of N6-hydroxyadenine Nucleosides and Related Derivatives

Alkylating Nucleosides

Molecular Engineering: A General Approach to QSAR

Towards more Realistic Computer Simulations in Theoretical Molecular Biology

Ab Initio Quantum Chemical Approach to the Antibiotic Activity of Betalactams

Cyclic Analogues of Agonists as a Tool for Structure-Activity Relationships

Thromboxane A2 and Atherosclerosis

Biological Activities of some Metabolites and Analogues of Prostacyclin

The role of Platelet Inhibitors in Degenerative Vascular Diseases

Thromboxane-dependent Platelet Aggregation: Role and Limitations

Pharmacological and Biochemical Studies on Benzodiazepines

Receptor Mapping

Multiple Analgesic Receptors

New Approaches to Antiviral Agents

New Antiviral Agents: Some Recent Developments

Chemical Control of Oncogenic Events by RNA Tumor Viruses

General Mechanisms of Action of Hypolipidemic Agents

Central Mechanisms of Anorectic Agents

Antiobesity Agents Acting through Peripheral Mechanisms

Agents Acting on Mucociliary System

Adrenergic and Anticholinergic Bronchodilators do they Act as Bronchospasmolytics

Agents Acting on the Immunological Component in Respiratory Diseases

Present Knowledge of Gaba Receptor Agonists

New Trends in Minor Tranquilizers

Trans-N-Alkyl-6,7-Dihydroxyoctahydrobenzo [g] -Quinolines: Apomorphine Congeners Lacking the Non-oxygenated Aromatic Ring

Dopamine Receptor Blockade by Substitute Benzamide Drugs

Target Enzyme-Activated Irreversible Enzyme Inhibitors

Proteolytic Enzyme Inhibitors

Sialidases and their Inhibitors

Inhibitors of Cyclic Nucleotide Phosphodiesterases

The Systematics of Bioactive Peptide Structure-Activity Relationships

Chemical and Biological Properties of Beta-Lipotropin and Endorphins: Metabolism and Mechanisms of Inactivation

Neurohypophysial Hormones and Neurophysins: Structures, Precursors, and Evolution

Relations between the Structure and Biological Activity of Insulin

Index

Details

No. of pages:
526
Language:
English
Copyright:
© Pergamon 1981
Published:
Imprint:
Pergamon
eBook ISBN:
9781483158211

About the Editor

Federico G. De Las Heras

Salvador Vega