Mechanisms of Toxicity and Metabolism is the sixth volume of the proceedings of the Sixth International Congress of Pharmacology, organized by the Finnish Pharmacological Society and held in Helsinki, Finland, on July 20-25, 1975. Contributors focus on the findings concerning the mechanisms of toxicity and metabolism and the developments in pharmacology and related areas of research. This volume has 24 chapters divided into four sections. After discussing the developmental aspects of drug metabolism and enzyme inhibitors of microbial origin, this book turns its attention to the interrelationships among various enzyme systems and physiological processes that are known to affect the distribution and metabolism of drugs. This text also highlights the reaction mechanisms of cytochrome P-450; the link between microsomal drug oxidation and glucuronidation; and the pharmacokinetics of the first pass effect. The reader is then introduced to the toxicity of food additives and the toxicity and metabolism of plasticizers and plastics. This volume concludes with a chapter that evaluates some of the biochemical and pharmacologic effects of di-2-ethylhexyl phthalate (DEHP). This book will appeal to scientists representing all the major areas of pharmacology, including clinical pharmacology and toxicology, as well as to internists, psychiatrists, neurologists, and anesthesiologists.
Contributors Preface Invited Lectures Developmental Aspects of Drug Metabolism Enzyme Inhibitors of Microbial Origin Drug Metabolism Symposium on Drug Metabolism: Introductory Remarks Reaction Mechanisms of Cytochrome P-450 Linkage of Microsomal Drug Oxidation and Glucuronidation Perspectives of the Relative Importance of Hepatic and Extrahepatic Drug Metabolism Enterohepatic Circulation and Drug Bioavailability Pharmacokinetics of the First Pass Effect Importance of Dose-Threshold for Drug-Induced Tissue Lesions Symposium on Drug Metabolism: Concluding Remarks Evaluation of Toxicity of Food Additives Evaluation of Toxicity of Food Additives: Opening Remarks Evaluation of Cyclamate and Saccharin Nitrofuran Compounds as a Food Additive Synthetic Antioxidants: A Re-appraisal of Safety Toxicology of Colors as Food Additives The Role WHO in the Evaluation of the Toxicity of Food Additives Concluding Remarks Toxicity and Metabolism of Plasticizers and Plastics Leachable Components and Biocompatibility of PVC Medical Devices The Release of Plasticizers from PVC Tubing Contamination of Blood with Phthalate Esters Metabolism and Acute Lung Toxicity of Solubilized di(2-ethylhexyl) Phthalate (DEHP) in Rats Toxicity of Phthalate Esters to Tissue Cultures Metabolism and Autoradiographic Localization of Di-2-Ethylhexyl Phthalate (DEHP) in Mice and Model Ecosystem Some Biochemical and Pharmacologie Effects of Di-2-Ethylhexyl Phthalate (DEHP) Contents of Volumes 1—6 Subject Index
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- © Pergamon 1976
- 1st January 1976
- eBook ISBN: