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Mechanisms of Regeneration - 1st Edition - ISBN: 9780123914989, 9780123944108

Mechanisms of Regeneration, Volume 108

1st Edition

Serial Volume Editor: Brigitte Galliot
eBook ISBN: 9780123944108
Hardcover ISBN: 9780123914989
Imprint: Academic Press
Published Date: 7th February 2014
Page Count: 368
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Table of Contents

  • Contributors
  • Preface
  • Chapter One: Genetic and Epigenetic Controls of Plant Regeneration
    • Abstract
    • 1 Introduction
    • 2 Types of Regeneration in Higher Plants
    • 3 Tissue Regeneration
    • 4 De novo Organogenesis
    • 5 Somatic Embryogenesis
    • 6 Wound Signal in Plant Regeneration
    • 7 Regeneration in Moss
    • 8 Concluding Remarks and Perspectives
    • Acknowledgments
  • Chapter Two: The Hormonal Control of Regeneration in Plants
    • Abstract
    • 1 Introduction
    • 2 Spatiotemporal Patterns of Hormonal Response are Critical to De novo Regeneration
    • 3 Hormonal Biosynthesis Contributes to the Distribution of the Hormonal Response and De novo Regeneration
    • 4 Hormonal Signaling in De novo Plant Regeneration
    • 5 Hormone Interactions During Plant Regeneration
    • 6 Concluding Remarks and Perspectives
    • Acknowledgments
  • Chapter Three: Histone Modifications and Regeneration in the Planarian Schmidtea mediterranea
    • Abstract
    • 1 Introduction
    • 2 Histone Families and Variants in S. mediterranea
    • 3 A Survey of Histone Modifications in S. mediterranea
    • 4 Distribution of Acetylation Marks in Planarian Cells
    • 5 Epigenetic Modifying Enzymes in Planarians
    • 6 Histone Modifications, Stem Cells, and Cell Lineages
    • 7 Conclusions
    • Acknowledgments
  • Chapter Four: Control of Growth During Regeneration
    • Abstract
    • 1 Cells Participating in Regenerative Growth
    • 2 Recognizing Tissue Damage to Initiate Regeneration
    • 3 Regenerative Growth is Controlled by Signaling Networks
    • 4 Control of Regenerative Growth by Organ Patterning
    • 5 Suppression of Regenerative Growth
    • 6 Conclusion
    • Acknowledgments
  • Chapter Five: Cell Death
    • Abstract
    • 1 Introduction to Regenerative Cell Death
    • 2 What Timing for Spontaneous Cell Death During Regeneration?
    • 3 Injury Signals Triggering Regenerative Cell Death
    • 4 Caspase Activation, a Versatile Tool to Regulate Regeneration
    • 5 A Complex Paracrine Control of Regeneration Through Cell Death
    • Acknowledgments
  • Chapter Six: Mechanisms of Systemic Wound Response in Drosophila
    • Abstract
    • 1 Introduction
    • 2 Basic Processes Involved in Local Wound Responses
    • 3 Organismal Level of Systemic Wound Response in Drosophila
    • 4 Conclusion
    • Acknowledgments
  • Chapter Seven: Postembryonic Organogenesis of the Digestive Tube
    • Abstract
    • 1 Introduction
    • 2 Mechanisms of Digestive Tract Regeneration in Different Animal Models
    • 3 Emerging Principles of Intestinal Regeneration Across Eumetazoans
    • 4 Conclusions
    • Acknowledgments
  • Chapter Eight: Aging and Regeneration in Vertebrates
    • Abstract
    • 1 Aging and Regeneration
    • 2 Effects of Aging on Stem Cells and Cell Turnover
    • 3 Age-Dependent Changes of Regeneration Potential After Injury
    • 4 Concluding Remarks
    • Acknowledgments
  • Chapter Nine: Skeletal Muscle Degeneration and Regeneration in Mice and Flies
    • Abstract
    • 1 Introduction
    • 2 Skeletal Muscle Formation (Myogenesis) and Maturation in Mice and Flies
    • 3 Homeostasis and a Range of Factors Essential for Optimal Muscle Function
    • 4 Mechanisms of Muscle Hypertrophy
    • 5 Muscle Hypertrophy and Atrophy in Insects: Comparison with Other Species
    • 6 Muscle Degeneration Versus Necrosis/Regeneration in Mice and Flies
    • 7 Muscle Degeneration in Neuromuscular Diseases
    • 8 Sarcopenia: Age-Related Degeneration with Loss of Skeletal Muscle Mass and Function
    • 9 Conclusions
    • Acknowledgments
    • Glossary
  • Chapter Ten: Mathematical Modeling of Regenerative Processes
    • Abstract
    • 1 Introduction
    • 2 Models for the Initiation of a Regenerative Response
    • 3 Models for Tissue Patterning During Regenerate Growth
    • 4 Models for Arresting the Regenerative Response
    • 5 Open Problems
    • 6 Conclusions and Perspectives
    • Acknowledgments
  • Chapter Eleven: Re-engineering Development to Instruct Tissue Regeneration
    • Abstract
    • 1 Introduction
    • 2 Limb Skeletal Development
    • 3 Endogenous Bone Repair Processes
    • 4 Classical Approaches to Bone Tissue Engineering
    • 5 Developmental Engineering of Bone
    • 6 Developmental Re-engineering of Bone Tissue
    • 7 Conclusions
    • Acknowledgments
  • Glossary
  • Index


This new volume of Current Topics in Developmental Biology covers the area of mechanisms in regeneration. With an international board of authors, it provides a comprehensive set of reviews covering such topics as control of growth during regeneration, skeletal muscle degeneration and regeneration in mammals and flies, and suppression of regeneration in mammals.

Key Features

  • Covers the area of mechanisms in regeneration
  • International board of authors
  • Provides a comprehensive set of reviews


Researchers in cell, developmental, and molecular biology; genetics


No. of pages:
© Academic Press 2014
7th February 2014
Academic Press
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Serial Volume Editor

Brigitte Galliot

Brigitte Galliot

My scientific interest has always been focused on the different aspects of development, from the first morphogenetic stages to the complex mechanisms of neurogenesis and regeneration. This led me to study medicine (Paris, France) and to start a medical career in the field of embryology and pediatrics. I however soon realized that my scientific interests could only be satisfied after a more complete formation in basic biological and biochemical sciences. My nomination as MD resident in Strasbourg hospitals gave me the unexpected opportunity to join one of the leading French laboratories in the field of molecular biology (Pierre CHAMBON) and to acquire a formation as a molecular biologist. After a Master in the biochemistry of transcription I started a PhD work in the field of molecular genetics of development, where I characterized transcription factors (Hox genes) involved in the establishment of the vertebrate body plan, using the mouse as a model system. Thereafter I joined the laboratory of Chica SCHALLER in Heidelberg (Germany) for a post-doctoral stage to study the molecular developmental biology of Hydra. This freshwater cnidarian polyp, which displays a rather simple apical to basal organization but differentiates a sophisticated nervous system and is capable of budding and regeneration, is a potent model system to study the biology of stem cells, the mechanisms of regeneration.

The discovery since 1984 that all animals share a similar complement of genes convinced me of the paradigmatic value of this little animal to understand some fundamental processes that support cell and developmental plasticity in metazoans. I started to settle a molecular biology approach, which led in the cloning of several transcription factors, homeobox- and bZIP-containing genes, unexpectedly similar to their vertebrate counterparts. Moreover their regulation during regeneration confirmed our hope that developmental pathways had been conserved throughout evolution. Since 1993, in my own laboratory at the University of Geneva (Switzerland), we focus on the signaling pathway(s) leading to the reactivation of a developmental program after injury, and to de novo neurogenesis in the adult Hydra. My double formation as MD and PhD in the field of human embryology and molecular developmental biology gives me the chance to appreciate the scientific advances from both sides, medical and biological. No doubt that in the coming years a better understanding of the cellular plasticity during regenerative processes will provide direct implications for facing human pathologies.

Affiliations and Expertise

Department of Genetics and Evolution, University of Geneva, Switzerland