Mechanisms of Memory

2nd Edition

Authors: J. David Sweatt
Print ISBN: 9780123749512
eBook ISBN: 9780080959191
Imprint: Academic Press
Published Date: 12th November 2009
Page Count: 362
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'Sweatt has done a superb and scholarly job of telling the story of this field.' - Howard Eichenbaum, Editor in Chief Hippocampus, Boston University
'It is definitely worth publishing a second edition. David is a leader in the field. The book is well written and has lots of nice figures making it easy to teach from.' - Daniel Johnston, Director, Center for Learning and Memory; Director, Institute for Neuroscience, University of Texas at Austin
Sweatt is an outstanding writer and conveyer of complex concepts. He engages readers with lots of examples and detailed explanations for the most difficult material. It is a superb book for its audience.' - Laura Flashman, Associate Professor of Psychiatry; Director, Neuropsychology Program, Dartmouth Hitchcock Medical Center, Lebanon, NH

Human learning and memory is likely the most highly evolved and sophisticated biological process in existence. Many who work on the cellular and molecular processes of learning and memory are tempted to throw up their hands in frustration and conclude that the problem is insoluble.
Mechanisms of Memory 2nd edition completely revises this still unique reference to make the book more accessible, full updated with the many new advances in molecular neuroscience of the past six years, and expanded in scope to include four new chapters on the role of memory in neurological and psychiatric disorders and very promising approaches to translate the our knowledge about the molecular basis of memory to new treatment options in clinical practice. The book presents the complex puzzle of the molecular basis of memory in an integrated way that is understandable and accessible to students of Neuroscience, Psychology, Molecular Biology, while still being of great value to active scientists in the field. Sweatt creates a framework of thinking about synaptic plasticity and memory at the molecular level, incorporating this extreme biochemical complexity into our thinking about memory. Five year

Table of Contents

Foreword to First Edition Preface to First Edition Preface to Second Edition Acknowledgments

  1. Introduction: The Basics of Psychological Learning and Memory Theory I. Introduction A. Categories of Learning and Memory B. Memory Exhibits Long-Term and Short-Term Forms II . Short-Term Memory A. Sensory Memory and Short-Term Storage B. Working Memory C. The Prefrontal Cortex and Working Memory D. Reverberating Circuit Mechanisms Contrast with Molecular Storage Mechanisms for Long- Term Memory III. Unconscious Learning A. Simple Forms of Learning B. Unconscious Learning and Unconscious Recall C. Unconscious Learning and Subject to Conscious Recall D. Operant Conditioning E. Currently Popular Associative Learning Paradigms IV . Conscious Learning — Subject to Conscious and Unconscious Recall A. Declarative Learning B. Spatial Learning V . Summary Further Reading Journal Club Articles References
  2. Studies of Human Learning and Memory I. Introduction — Historical Precedents with Studies of Human Subjects A. Amnesias B. Memory Consolidation II . The Hippocampus in Human Declarative, Episodic, and Spatial Memory A. Anatomy of the Hippocampal Formation B. Lesion Studies in Human Memory Formation C. Imaging Studies III . Motor Learning A. Anatomy B. Habits C. Stereotyped Movements D. Sequence Learning IV . Prodigious Memory A. Mnemonists B. Savant Syndrome C. You are a Prodigy V. Summary Further Reading Journal Club Articles References
  3. Non-Associative Learning and Memory I. Introduction — The Rapid Turnover of Biomolecules II. Short-Term, Long-Term, and Ultralon


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About the Author

J. David Sweatt

David Sweatt obtained his B.S. in Chemistry from the University of South Alabama before attending Vanderbilt University, where he was awarded a Ph.D. for studies of intracellular signaling mechanisms. He then did a post-doctoral Fellowship at the Columbia University Center for Neurobiology and Behavior, working on memory mechanisms in the laboratory of Nobel laureate Eric Kandel. From 1989 to 2006 he was a member of the Neuroscience faculty at Baylor College of Medicine in Houston, Texas, rising through the ranks there to Professor and Director of the Neuroscience Ph.D. program. Dr. Sweatt’s laboratory studies biochemical mechanisms of learning and memory. In addition, his research program also investigates mechanisms of learning and memory disorders, such as mental retardation and aging-related memory dysfunction. He is currently the Evelyn F. McKnight endowed Chairman of the Department of Neurobiology at UAB Medical School, and the Director of the Evelyn F. McKnight Brain Institute at the University of Alabama in Birmingham. He also is a Professor the Departments of Cell Biology, Genetics, and Psychology at UAB. Dr. Sweatt has won numerous awards and honors, including an Ellison Medical Foundation Senior Scholar Award, and election as a Fellow of the American Association for the Advancement of Science. This year he won (along with Michael Meaney and Catherine Dulac) the Ipsen Foundation International Prize in Neural Plasticity, one of the most prestigious awards in his scientific field. From 1998 until 2002 he attended drawing and painting classes at the Glassell School of Art of the Museum of Fine Arts, Houston. As an artist he explores the use of painting as a medium for expressing topics of interest in contemporary biomedical research. In 2009 he published a textbook, Mechanisms of Memory, which is illustrated with original paintings and describes current models for the molecular and cellular basis of memory formation.

Affiliations and Expertise

McKnight Brain Institute, Department of Neurobiology, University of Alabama at Birmingham, Birmingham, Alabama, USA