Mechanisms and Therapy of Liver Cancer

Mechanisms and Therapy of Liver Cancer

1st Edition - February 10, 2021

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  • Editors: Paul Fisher, Devanand Sarkar
  • eBook ISBN: 9780128240311
  • Hardcover ISBN: 9780128240304

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Mechanisms and Therapy of Liver Cancer, Volume 149, presents the latest information on the incidence and mortality of liver cancer research and how it has gained significant momentum because of its direct causative association with obesity-induced fatty liver disease. The literature on liver cancer is moving fast with exciting, novel findings, providing new insights reflected in the following updated chapters: Introduction and molecular classification of HCC, Signaling Pathways in Liver Cancer, HCV and HCC, NASH and HCC, Microbiome and Metabolic Abnormalities in HCC, Systemic Therapy of Liver Cancer, Immunotherapy of Liver Cancer, and Desmoplastic Tumor Microenvironment and Intrahepatic Cholangiocarcinoma Progression: Mechanisms and Therapeutic Implications.

Key Features

  • Provides the latest information on liver cancer research
  • Offers outstanding and original reviews on a range of topics focused on liver cancer
  • Serves as an indispensable reference on liver cancer for researchers and students alike


Researchers and students in basic and translational cancer research, with special emphasis on liver diseases and liver cancer, as well as related areas in genetics, immunology, pharmacology and cell and molecular biology

Table of Contents

  • 1. Hepatocellular carcinoma (HCC): Epidemiology, etiology and molecular classification
    Saranya Chidambaranathan-Reghupaty, Paul B. Fisher, and Devanand Sarkar
    2. Signaling pathways in hepatocellular carcinoma
    Teresa Garcia-Lezana, Juan Luis Lopez-Canovas, and Augusto Villanueva
    3. Hepatitis C virus associated hepatocellular carcinoma
    Mousumi Khatun, Ranjit Ray, and Ratna B. Ray
    4. NAFLD-related HCC
    Bubu A. Banini and Arun J. Sanyal
    5. Atypical immunometabolism and metabolic reprogramming in liver cancer: Deciphering the role of gut microbiome
    Rachel M. Golonka and Matam Vijay-Kumar
    6. Systemic therapy of liver cancer
    Tarik Demir, Sunyoung S. Lee, and Ahmed O. Kaseb
    7. Immunotherapy in hepatocellular cancer
    Christos Fountzilas, Rachel Evans, Sabah Alaklabi, and Renuka Iyer
    8. Intrahepatic cholangiocarcinoma: Morpho-molecular pathology, tumor reactive microenvironment, and malignant progression
    Alphonse E. Sirica, Mario Strazzabosco, and Massimiliano Cadamuro

Product details

  • No. of pages: 402
  • Language: English
  • Copyright: © Academic Press 2021
  • Published: February 10, 2021
  • Imprint: Academic Press
  • eBook ISBN: 9780128240311
  • Hardcover ISBN: 9780128240304

About the Serial Volume Editors

Paul Fisher

Paul Fisher
Paul B. Fisher, MPh, PhD, FNAI, Professor and Chairman, Department of Human and Molecular Genetics, Director, VCU Institute of Molecular Medicine Thelma Newmeyer Corman Chair in Cancer Research in the VCU Massey Cancer Center, VCU, School of Medicine, Richmond, VA, and Emeritus Professor, Columbia University, College of Physicians & Surgeons, New York, NY. Dr. Fisher is among the top 10% of NIH funded investigators over the past 35-years, published approximately 625 papers and reviews, and has 55 issued patents. He pioneered novel gene/discovery approaches (subtraction hybridization), developed innovative therapeutic approaches (Cancer Terminator Viruses), presented numerous named and distinguished lectures, founded several start-up companies, was Virginia Outstanding Scientist of 2014 and elected to the National Academy of Inventors in 2018. Dr. Fisher is a prominent nationally and internationally recognized cancer research scientist focusing on understanding the molecular and biochemical basis of cancer development and progression to metastasis and using this garnered information to develop innovative approaches for diagnosing and treating cancer. He discovered and patented novel genes and gene promoters relevant to cancer growth control, differentiation and apoptosis. His discoveries include the first cloning of p21 (CDK inhibitor), human polynucleotide phosphorylase, mda-9/syntenin (a pro-metastatic gene), mda-5 and mda-7/IL-24, which has shown promising clinical activity in Phase I/II clinical trials in patients with advanced cancers. Dr. Fisher alsohas a documented track record as a successful seasoned entrepreneur. He was Founder and Director of GenQuest Incorporated, a functional genomics company, which merged with Corixa Corporation in 1998, traded on NASDAQ and was acquired by GlaxoSmithKline in 2006. He discovered the cancer-specific PEG-Prom, which is the core technology of Cancer Targeting Systems (CTS, Inc.), a Virginia/Maryland-based company (at Johns Hopkins Medical Center) focusing on imaging and therapy (“theranostics”) of metastatic cancer (2014) by Drs. Fisher and Martin G. Pomper. He co-founded InVaMet Therapeutics (IVMT) and InterLeukin Combinatorial Therapies (ILCT) with Dr. Webster K. Cavenee (UCSD) (2017/2018).

Affiliations and Expertise

Department of Human and Molecular Genetics, VCU Institute of Molecular Medicine, VCU Massey Cancer Center, Virginia Commonwealth University, School of Medicine, Virginia, USA

Devanand Sarkar

Dr. Sarkar received his MBBS from Dhaka Medical College, Bangladesh and PhD from Nagoya University, Japan. After postdoctoral training in Columbia University, NY he joined Virginia Commonwealth University (VCU) as a faculty where he is now a Professor in the Department of Human and Molecular Genetics, and Associate Director of Education and Training at Massey Cancer Center. Dr. Sarkar’s research focuses on identifying novel regulators of hepatocellular carcinoma (HCC), especially obesity-induced HCC, and developing targeted gene- and immunotherapy based on the accrued knowledge. Dr. Sarkar has published more than 280 papers and his research is funded by NCI, NIDDK and DOD.

Affiliations and Expertise

Professor in the Department of Human and Molecular Genetics, and Associate Director of Education and Training at Massey Cancer Center, Virginia Commonwealth University (VCU)

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