Mechanisms and Pathways of Heterotrimeric G Protein Signaling
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Mechanisms and Pathways of Heterotrimeric G Protein Signaling

1st Edition - October 1, 2007

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  • Author: Stephen Sprang
  • Hardcover ISBN: 9780120342884
  • eBook ISBN: 9780080552699

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Description

This volume in the Advances in Protein Chemistry series features cutting-edge articles on topics in protein chemistry. This volume includes chapters on the structural basis of effector regulation and signal termination in heterotrimeric GƒÑƒnƒnproteins; How do receptors activate G proteins; Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads; Activation of G protein coupled receptors; Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells; Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins.

Readership

Researchers in biochemistry, molecular biology, cell biology, and biophysics.

Table of Contents

  • 1. Structural basis of effector regulation and signal termination in heterotrimeric GƒÑƒnƒnproteins
    Stephen R. Sprang, Zhe Chen and Xinlin Du

    2. How do receptors activate G proteins?
    William M. Oldham and Heidi E. Hamm

    3. Some mechanistic insights into GPCR activation from detergent solubilized ternary complexes on beads
    Tione Buranda, Anna Waller, Yang Wu, Peter C. Simons, Sean Biggs, Eric R. Prossnitz and Larry A. Sklar

    4. Activation of G protein coupled receptors
    Xavier Deupi and Brian Kobilka

    5. Kinetic analysis of g-protein-coupled receptor signaling using fluorescence resonance energy transfer in living cells
    Martin J. Lohse, Carsten Hoffmann, Viacheslav O. Nikolaev, Jean-Pierre Vilardaga and Moritz Bunemann

    6. Regulation of Rho Guanine Nucleotide Exchange Factors (RhoGEFs) by G proteins
    Paul C. Sternweis, Angela M. Carter, Zhe Chen, Shahab M. Danesh, Ying-Fan Hsiung, and William D. Singe

Product details

  • No. of pages: 290
  • Language: English
  • Copyright: © Academic Press 2007
  • Published: October 1, 2007
  • Imprint: Academic Press
  • Hardcover ISBN: 9780120342884
  • eBook ISBN: 9780080552699

About the Author

Stephen Sprang

Affiliations and Expertise

University of Texas Southwestern Medical Center, Dallas, Texas, USA

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